[1]吴 倩,王一非.中西医结合治疗肺癌脑转移疗效与安全性的Meta分析[J].医学信息,2022,35(10):120-125.[doi:10.3969/j.issn.1006-1959.2022.10.029]
 WU Qian,WANG Yi-fei.Meta-analysis of Efficacy and Safety of Integrated Traditional Chinese and Western Medicine in the Treatment of Brain Metastasis of Lung Cancer[J].Medical Information,2022,35(10):120-125.[doi:10.3969/j.issn.1006-1959.2022.10.029]
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中西医结合治疗肺癌脑转移疗效与安全性的Meta分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年10期
页码:
120-125
栏目:
论著
出版日期:
2022-05-15

文章信息/Info

Title:
Meta-analysis of Efficacy and Safety of Integrated Traditional Chinese and Western Medicine in the Treatment of Brain Metastasis of Lung Cancer
文章编号:
1006-1959(2022)10-0120-06
作者:
吴 倩王一非
(1.北京智源人工智能研究院,北京 100084;2.中国中医科学院广安门医院南院区急诊科,北京 102699)
Author(s):
WU QianWANG Yi-fei
(1.Beijing Academy of Artificial Intelligence,Beijing 100084,China; 2.South District of Guang’anmen Hospital,Chinese Academy of Traditional Chinese Medicine,Beijing 102699,China)
关键词:
肺癌脑转移中西医结合治疗生活质量
Keywords:
Lung cancerBrain metastasisIntegrated traditional Chinese and western medicineQuality of life
分类号:
R734.2
DOI:
10.3969/j.issn.1006-1959.2022.10.029
文献标志码:
A
摘要:
目的 系统评价中西医结合治疗肺癌脑转移(BMs)的疗效与安全性。方法 通过计算机和人工搜索的方法检索以下内容:英文数据库(Embase、Cochrane Library、PubMed)和中文数据库(中国生物医学数据库、中国知网数据库、维普期刊数据库和万方数据库),自建库至2020年5月筛选关于中西医结合治疗肺癌BMs的随机对照研究,无语言限制。Cochrane手册用于评估偏倚风险。所有统计分析均使用RevMan(5.3版)进行。结果 共包括7项随机对照试验(494例患者)。Meta分析显示,接受中西医结合治疗患者的客观缓解率(OR=3.82,95%CI:2.52~5.81,P<0.01)、1年生存率(OR=2.43,95%CI:1.26~4.65,P<0.01)和生活质量(OR=5.37,95%CI:2.97~9.70,P<0.01)均优于接受单纯西医治疗患者。结论 中西医结合治疗肺癌BMs的疗效确切,可延长患者生存时间提高生活质量,应用安全有效。
Abstract:
Objective To systematically evaluate the efficacy and safety of integrated traditional Chinese and western medicine in the treatment of brain metastases (BMs) of lung cancer.Methods The following contents were searched by computer and manual search : English database (EMBASE, Cochrane Library, PubMed) and Chinese database (China Biomedical Database, CNKI database, VIP journal database and Wanfang database). From the establishment of the database to May 2020, randomized controlled studies on the treatment of lung cancer BMs with integrated Chinese and Western medicine were screened without language limitation. The Cochrane Handbook was used to assess the risk of bias. All statistical analysis was performed using RevMan (5.3 edition).Results The results included seven randomized controlled trials ( 494 patients ). Meta-analysis showed that the objective remission rate (OR=3.82, 95%CI:2.52-5.81,P<0.01), 1-year survival rate (OR=2.43, 95%CI:1.26-4.65, P<0.01) and quality of life (OR=5.37, 95%CI:2.97-9.70, P<0.01) of patients treated with integrated traditional Chinese and western medicine were better than those of patients treated with western medicine alone.Conclusion The combination of traditional Chinese and western medicine is effective in the treatment of lung cancer BMs, which can improve the survival time and quality of life of patients, and is safe and effective.

参考文献/References:

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更新日期/Last Update: 1900-01-01