[1]汤海霞,班 涛.大黄素与心血管疾病的研究[J].医学信息,2022,35(11):19-21,32.[doi:10.3969/j.issn.1006-1959.2022.11.006]
 TANG Hai-xia,BAN Tao.Research on Emodin and Cardiovascular Diseases[J].Medical Information,2022,35(11):19-21,32.[doi:10.3969/j.issn.1006-1959.2022.11.006]
点击复制

大黄素与心血管疾病的研究()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年11期
页码:
19-21,32
栏目:
综述
出版日期:
2022-06-01

文章信息/Info

Title:
Research on Emodin and Cardiovascular Diseases
文章编号:
1006-1959(2022)11-0019-04
作者:
汤海霞班 涛
(1.达州中医药职业学院,四川 达州 635000;2.哈尔滨医科大学药学院药理教研室,黑龙江 哈尔滨 150086)
Author(s):
TANG Hai-xiaBAN Tao
(1.Dazhou Vocational College of Chinese Medicine,Dazhou 635000,Sichuan,China;2.Department of Pharmacology,College of Pharmacy,Harbin Medical University,Harhin 150086,Heilongjiang,China)
关键词:
大黄素心血管疾病心肌梗死动脉粥样硬化高血压
Keywords:
EmodinCardiovascular diseasesMyocardial infarctionAtherosclerosisHypertension
分类号:
R285;54
DOI:
10.3969/j.issn.1006-1959.2022.11.006
文献标志码:
A
摘要:
大黄素是一种天然蒽醌衍生物,又名泻素,多存在于蓼科植物虎杖以及大黄、何首乌等干燥的根茎和叶,是中成药大黄的重要活性成分。研究表明,大黄素与多种心血管疾病密切相关,具有抗炎、抗肿瘤、抗心肌缺血、抑制血管平滑肌增殖、保护胃肠道等药理活性。本文就大黄素在心血管疾病中的作用作一综述,以期为大黄素与心血管疾病的研究提供参考。
Abstract:
Emodin is a natural anthraquinone derivative, also known as laxin, which exists in Polygonum cuspidatum and dried rhizomes and leaves of rhubarb and Polygonum multiflorum. It is an important active ingredient of rhubarb. Studies have shown that emodin is closely related to a variety of cardiovascular diseases, with anti-inflammatory, anti-tumor, anti-myocardial ischemia, inhibition of vascular smooth muscle proliferation, gastrointestinal protection and other pharmacological activities. This article reviews the role of emodin in cardiovascular diseases, in order to provide reference for the study of emodin and cardiovascular diseases.

参考文献/References:

[1]沈丹洋,张曼晖.农村男性人群体质指数与心血管疾病死亡关系的前瞻性随访研究[J].中华流行病学杂志,2020,41(12):2072-2079.[2]杨春澜,孟祥武,郑龙,等.大黄素通过TLR4/NF-κB信号通路减轻缺糖/缺氧对小胶质细胞的损伤[J].中国病理生理杂志,2019,35(12):2285-2289.[3]Zhai C,Qian G,Wu H,et al.Knockdown of circ_0060745 alleviates acute myocardial infarction by suppressing NF-κB activation[J].J Cell Mol Med,2020,24(21):12401-12410.[4]Cui Y,Chen LJ,Huang T,et al.The pharmacology, toxicology andtherapeutic potential of anthraquinone derivative emodin[J].Chin J Nat Med,2020,18(6):425-435.[5]Zhang X,Qin Q,Dai H,et al.Emodin protects H9c2 cells from hypoxia-induced injury by up-regulating miR-138 expression[J].Braz J Med Biol Res,2019,52(3):179-194.[6]Niu N,Xu S,Xu Y,et al.Targeting Mechanosensitive Transcription Factors in Atherosclerosis[J].Trends Pharmacol Sci,2019,40(4):253-266.[7]Badimon L,Pena E,Arderiu G,et al.C-Reactive Protein in Atherothrombosis and Angiogenesis[J].Front Immunol,2018,9:430.[8]Pang X,Liu J,Li Y,et al.Emodin Inhibits Homocysteine-Induced C-Reactive Protein Generation in Vascular Smooth Muscle Cells by Regulating PPARγ Expression and ROS-ERK1/2/p38 Signal Pathway[J].PLoS One,2015,10(7):131-141.[9]Lin W,Zhong M,Liang S,et al.Emodininhibits migration and invasion of MHCC-97H human hepatocellular carcinomacells[J].Exp Ther Med.2016,12(5):3369-3374.[10]Wang Y,Wang W,Xu H,et al.Non-Lethal Sonodynamic Therapy Inhibits Atherosclerotic Plaque Progression in ApoE-/- Mice and Attenuates ox-LDL-mediated Macrophage Impairment by Inducing Heme Oxygenase-1[J].Cell Physiol Biochem,2017,41(6):2432-2446.[11]Qian J,Gao Q.Sonodynamic Therapy Mediated by Emodin Induces the Oxidationof Microtubules to Facilitate the Sonodynamic Effect[J].Ultrasound Med Biol,2018,44(4):853-860.[12]Xiao D,Hu Y,Fu Y,et al.Emodin improves glucose metabolism by targeting microRNA-20b in insulin-resistant skeletal muscle[J].Phytomedicine,2019,59:152758.[13]Wu Z,Chen Q,Ke D,et al.Emodin protects against diabetic cardiomyopathy by regulating the AKT/GSK-3β signaling pathway in the rat model[J].Molecules,2014,19(9):14782-14793.[14]Liu Z,Ma N,Zhong Y.Antiviral effect of emodin from Rheum palmatum against coxsakievirus B5 and human respiratory syncytial virus in vitro[J].J Huazhong Univ Sci Technolog Med Sci,2015,35(6):916-922.[15]Zhang HM,Wang F,Qiu Y,et al.Emodin inhibits coxsackievirus B3 replication via multiple signalling cascades leading to suppression of translation[J].Biochem J,2016,473(4):473-485.[16]Voelkl J,Lang F,Eckardt KU,et al.Signaling pathways involved in vascular smooth muscle cell calcification during hyperphosphatemia[J].Cell Mol Life Sci,2019,76(11):2077-2091[17]Masaki N,Ido Y,Yamada T,et al.Endothelial Insulin Resistance of Freshly Isolated Arterial Endothelial Cells from Radial Sheaths in Patients With Suspected Coronary Artery Disease[J].J Am Heart Assoc,2019,8:e010816.[18]Shou X,Zhou R,Zhu L,et al.Emodin, A Chinese Herbal Medicine, Inhibits Reoxygenation-Induced Injury in Cultured Human Aortic Endothelial Cells by Regulating the Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) and Endothelial Nitric Oxide Synthase (eNOS) Signaling Pathway[J].Med Sci Monit.,2018,24:643-651.[19]Wang J,Zhang Y,Zhu Q,et al.Emodin protects mice against radiation-induced mortality and intestinal injury via inhibition of apoptosis and modulation of p53[J].Environ Toxicol Pharmacol,2016,46:311-318.[20]Gao Y,Zhang J,Li G,et al.Protection of vascular endothelial cells from high glucose-induced cytotoxicity by emodin[J].Biochem Pharmacol,2015,94(1):39-45.[21]Frismantiene A,Philippova M,Erne P,et al.Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity[J].Cell Signal,2018,52(2):48-64.[22]Lim KM,Kwon JH,Kim K,et al.Emodin inhibits tonic tension through suppressing PKCδ-mediated inhibition of myosin phosphatase in rat isolated thoracic aorta[J].Br J Pharmacol,2014,171(18):4300-4310.[23]Huang X,Liu Z,Shen L,et al.Augmentation of miR-202 in varicose veins modulates phenotypic transition of vascular smooth muscle cells by targeting proliferator-activated receptor-γ coactivator-1α[J].J Cell Biochem,2019,120(6):10031-10042.[24]Xu K,Al-Ani MK,Wang C,et al.Emodin as a selective proliferative inhibitor of vascular smooth muscle cells versus endothelial cells suppress arterial intima formation[J].Life Sci,2018,207:9-14.[25]Lu R,Tang F,Zhang Y,et al.Comparison of Drug-Eluting and Bare Metal Stents in Patients With Chronic Kidney Disease: An Updated Systematic Review and Meta-Analysis[J].J Am Heart Assoc,2016,5(11):e003990.[26]Zhang HM,Wang F,Qiu Y,et al.Emodin inhibits coxsackievirus B3 replication via multiple signalling cascades leading to suppression of translation[J].Biochem J,2016,473:473-85.[27]邬瑾.心血管病患者药物涂层支架载入药物的筛选与应用[J].中国组织工程研究,2016,20(38):5770-5776.

相似文献/References:

[1]郭俊林,张 立.基质金属蛋白酶-2与冠状动脉粥样硬化性疾病的研究进展[J].医学信息,2018,31(04):27.[doi:10.3969/j.issn.1006-1959.2018.04.010]
 GUO Jun-lin,ZHANG Li.Progress of the Researchon Matrix Metalloproteinase-2 and Coronary Atherosclerotic Disease[J].Medical Information,2018,31(11):27.[doi:10.3969/j.issn.1006-1959.2018.04.010]
[2]王立民,刘有旺,王恩波,等.以大黄素为声敏剂介导声动力疗法对小鼠 动脉粥样硬化治疗作用的研究[J].医学信息,2018,31(06):58.[doi:10.3969/j.issn.1006-1959.2018.06.019]
 WANG Li-min,LIU You-wang,WANG En-bo,et al.Study on the Effect of Emodin on the Treatment of Atherosclerosis in Mice[J].Medical Information,2018,31(11):58.[doi:10.3969/j.issn.1006-1959.2018.06.019]
[3]张 慧,黄艳群,王 妮,等.基于美国全国住院病人样本的心血管疾病研究进展[J].医学信息,2018,31(07):43.[doi:10.3969/j.issn.1006-1959.2018.06.015]
 ZHANG Hui,HUANG Yan-qun,WANG Ni,et al.Research Progress of Cardiovascular Disease Based on National Inpatient Sample[J].Medical Information,2018,31(11):43.[doi:10.3969/j.issn.1006-1959.2018.06.015]
[4]平兰芝,黄小楼,胡天俊,等.CaMKⅡ在心血管疾病中的研究[J].医学信息,2022,35(10):59.[doi:10.3969/j.issn.1006-1959.2022.10.014]
 PING Lan-zhi,HUANG Xiao-lou,HU Tian-jun,et al.Research on the Role of CaMKⅡ in Cardiovascular Diseases[J].Medical Information,2022,35(11):59.[doi:10.3969/j.issn.1006-1959.2022.10.014]
[5]李 晶,黄 波.抗血小板药物治疗心血管疾病的研究现状[J].医学信息,2022,35(10):83.[doi:10.3969/j.issn.1006-1959.2022.10.020]
 LI Jing,HUANG Bo.Research Status of Antiplatelet Drugs in the Treatment of Cardiovascular Diseases[J].Medical Information,2022,35(11):83.[doi:10.3969/j.issn.1006-1959.2022.10.020]
[6]徐炜棉,郭金莲,王燕琴,等.铁代谢及铁蛋白与心血管疾病关系的现状分析[J].医学信息,2018,31(22):39.[doi:10.3969/j.issn.1006-1959.2018.22.012]
 XU Wei-mian,GUO Jin-lian,WANG Yan-qin,et al.Analysis of the Relationship between Iron Metabolism and Ferritin and Cardiovascular Diseases[J].Medical Information,2018,31(11):39.[doi:10.3969/j.issn.1006-1959.2018.22.012]
[7]刘瑞芳,赵 华,史红娟,等.益生菌与2型糖尿病心血管疾病的研究进展[J].医学信息,2019,32(18):29.[doi:10.3969/j.issn.1006-1959.2019.18.010]
 LIU Rui-fang,ZHAO Hua,SHI Hong-juan,et al.Advances in Research on Probiotics and Cardiovascular Diseases in Type 2 Diabetes[J].Medical Information,2019,32(11):29.[doi:10.3969/j.issn.1006-1959.2019.18.010]
[8]闫娜娜,李雪萍,李 亚,等.FGF23与心血管疾病的研究进展[J].医学信息,2019,32(19):43.[doi:10.3969/j.issn.1006-1959.2019.19.014]
 YAN Na-na,LI Xue-ping,LI Ya,et al.Progress in Research on FGF23 and Cardiovascular Diseases[J].Medical Information,2019,32(11):43.[doi:10.3969/j.issn.1006-1959.2019.19.014]
[9]袁国铭,陈新利,袁国娜,等.心脏病健康知识系统构建与应用[J].医学信息,2019,32(22):8.[doi:10.3969/j.issn.1006-1959.2019.22.003]
 YUAN Guo-ming,CHEN Xin-li,YUAN Guo-na,et al.The Construction and Application of Heart Health Knowledge System[J].Medical Information,2019,32(11):8.[doi:10.3969/j.issn.1006-1959.2019.22.003]
[10]杨 敏,汤云昭,倪长林.2型糖尿病患者心血管疾病的发病机制[J].医学信息,2020,33(06):56.[doi:10.3969/j.issn.1006-1959.2020.06.017]
 YANG Min,TANG Yun-zhao,NI Chang-lin.The Pathogenesis of Cardiovascular Disease in Patients with Type 2 Diabetes[J].Medical Information,2020,33(11):56.[doi:10.3969/j.issn.1006-1959.2020.06.017]

更新日期/Last Update: 1900-01-01