[1]阳 芳,黄 斌,覃超群,等.血清KL-6水平与安罗替尼治疗的非小细胞肺癌预后的关系[J].医学信息,2022,35(12):104-108.[doi:10.3969/j.issn.1006-1959.2022.12.025]
 YANG Fang,HUANG Bin,QIN Chao-qun,et al.Relationship Between Serum KL-6 Level and Prognosis of Non-small Cell Lung Cancer Treated with Anlotinib[J].Medical Information,2022,35(12):104-108.[doi:10.3969/j.issn.1006-1959.2022.12.025]
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血清KL-6水平与安罗替尼治疗的非小细胞肺癌预后的关系()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年12期
页码:
104-108
栏目:
论著
出版日期:
2022-06-15

文章信息/Info

Title:
Relationship Between Serum KL-6 Level and Prognosis of Non-small Cell Lung Cancer Treated with Anlotinib
文章编号:
1006-1959(2022)12-0104-05
作者:
阳 芳黄 斌覃超群
(桂林市人民医院呼吸与危重症医学科,广西 桂林 541002)
Author(s):
YANG FangHUANG BinQIN Chao-qunet al.
(Department of Respiratory and Critical Care Medicine,Guilin People’s Hospital,Guilin 541002,Guangxi,China)
关键词:
KL-6安罗替尼非小细胞肺癌预后
Keywords:
KL-6AnlotinibNon-small cell lung cancerPrognosis
分类号:
R734.2
DOI:
10.3969/j.issn.1006-1959.2022.12.025
文献标志码:
A
摘要:
目的 评估血清KL-6水平对安罗替尼治疗非小细胞肺癌患者预后的影响。方法 选取2020年1月-12月桂林市人民医院收治的80例非小细胞肺癌(NSCLC)患者为研究对象,根据是否接受安罗替尼治疗分为NSCLC组和安罗替尼+NSCLC组,各40例。NSCLC组接受常规治疗,安罗替尼+NSCLC组在常规治疗基础上联合安罗替尼口服治疗。比较两组血清KL-6水平,分析安罗替尼+NSCLC组血清KL-6水平与临床病理特征、生存时间的关系,Kaplan-Meier曲线和多变量Cox回归模型确定安罗替尼+NSCLC组患者预后不良的影响因素。结果 安罗替尼+NSCLC组血清KL-6水平低于NSCLC组,差异有统计学意义(P<0.05);不同年龄、性别、组织学类型、肿瘤分化程度的安罗替尼+NSCLC组患者血清KL-6水平比较,差异无统计学意义(P>0.05);不同病理分期和转移部位数的安罗替尼+NSCLC组患者血清KL-6水平比较,差异有统计学意义(P<0.05);高KL-6水平的安罗替尼+NSCLC组患者中位生存期、总生存时间少于低KL-6水平的患者,差异有统计学意义(P<0.05);多变量Cox回归模型显示,KL-6水平是影响安罗替尼+NSCLC组患者预后不良的独立因素。结论 血清KL-6水平可作为安罗替尼治疗的NSCLC患者预后的生物标志物。
Abstract:
Objective To evaluate the effect of serum KL-6 level on the prognosis of patients with non-small cell lung cancer treated with anrotinib.Methods A total of 80 patients with non-small cell lung cancer (NSCLC) admitted to Guilin People’s Hospital from January to December 2020 were selected as the research objects. They were divided into NSCLC group and Anrotinib+NSCLC group according to whether they received anrotinib treatment, with 40 cases in each group. The NSCLC group received routine treatment, and the anrotinib+NSCLC group received oral anrotinib treatment on the basis of routine treatment. The serum KL-6 levels of the two groups were compared, and the relationship between the serum KL-6 level of the anrotinib+NSCLC group and the clinical pathological characteristics and survival time was analyzed. Kaplan-Meier curve and multivariate Cox regression model were used to determine the influencing factors of poor prognosis in patients with anrotinib+NSCLC group.Results The serum KL-6 level in the anrotini+NSCLC group was lower than that in the NSCLC group, and the difference was statistically significant (P<0.05). There was no significant difference in the serum KL-6 level between the patients with different ages, genders, histological types, and tumor differentiation degrees in the anrotini+NSCLC group (P>0.05). There was statistically significant difference in serum KL-6 level of anlotinib+NSCLC patients with different pathological stages and number of metastasis sites (P<0.05). The median survival and overall survival time of patients with high KL-6 level in anlotinib+NSCLC group were lower than those with low KL-6 level, the differences were statistically significant (P<0.05). Multivariate Cox regression model showed that KL-6 level was an independent factor influencing poor prognosis of anlotinib+NSCLC patients.Conclusion Serum KL-6 level can be used as a biomarker for prognosis of NSCLC patients treated with anlotinib.

参考文献/References:

[1]Bray F,Ferlay J,Soerjomataram I,et al.Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2018,68(6):394-424.[2]Duma N,Santana-Davila R,Molina JR.Non-Small Cell Lung Cancer: Epidemiology,Screening, Diagnosis,and Treatment[J].Mayo Clin Proc,2019,94(8):1623-1640.[3]Jonna S,Subramaniam DS.Molecular diagnostics and targeted therapies in non-small cell lung cancer (NSCLC): an update[J].Discovery Medicine,2019,27(148):167-170.[4]Paz-Ares L,Socinski MA,Shahidi J,et al.Correlation of EGFR-expression with safety and efficacy outcomes in SQUIRE: a randomized, multicenter, open-label, phase Ⅲ study of gemcitabine-cisplatin plus necitumumab versus gemcitabine-cisplatin alone in the first-line treatment of patients with stage IV squamous non-small-cell lung cancer[J].Annals of Oncology,2016,27(8):1573-1579.[5]Alexander M,Kim SY,Cheng H.Update 2020: Management of Non-Small Cell Lung Cancer[J].Lung,2020,198(6):897-907.[6]Kohno N,Inoue Y,Hamada H,et al.Difference in sero-diagnostic values among KL-6-associated mucins classified as cluster 9[J].Int J Cancer Suppl,1994,8:81-83.[7]Stahel RA,Gilks WR,Lehmann HP,et al.Third International Workshop on Lung Tumor and Differentiation Antigens: overview of the results of the central data analysis[J].Int J Cancer Suppl,1994,8:6-26.[8]Tomita M,Ayabe T,Chosa E,et al.Prognostic Significance of a Tumor Marker Index Based on Preoperative Serum Carcinoembryonic Antigen and Krebs von den Lungen-6 Levels in Non-Small Cell Lung Cancer[J].Asian Pac J Cancer Prev,2017,18(1):287-291.[9]Zheng M,Lou A,Zhang H,et al.Serum KL-6, CA19-9, CA125 and CEA are Diagnostic Biomarkers for Rheumatoid Arthritis-Associated Interstitial Lung Disease in the Chinese Population[J].Rheumatology and Therapy,2021,8(1):517-527.[10]Tomita M,Ayabe T,Chosa E,et al.Prognostic significance of preoperative serum Krebs von den Lungen-6 level in non-small cell lung cancer[J].General Thoracic and Cardiovascular surgery,2016,64(11):657-661.[11]Zhao J,Han Y,Li J,et al.Prognostic value of KRAS/TP53/PIK3CA in non-small cell lung cancer[J]. Oncology Letters,2019,17(3):3233-3240.[12]Schabath MB,Cote ML.Cancer Progress and Priorities: Lung Cancer[J].Cancer Epidemiology,Biomarkers & Prevention,2019,28(10):1563-1579.[13]Hirsch FR,Suda K,Wiens J,et al.New and emerging targeted treatments in advanced non-small-cell lung cancer[J].Lancet (London, England),2016,388(10048):1012-1024.[14]Arbour KC,Riely GJ.Systemic Therapy for Locally Advanced and Metastatic Non-Small Cell Lung Cancer: A Review[J].JAMA,2019,322(8):764-774.[15]Ramalingam SS,Owonikoko TK,Khuri FR.Lung cancer: New biological insights and recent therapeutic advances[J].CA: A Cancer Journal for Clinicians,2011,61(2):91-112.[16]Pao W,Girard N.New driver mutations in non-small-cell lung cancer[J].The Lancet Oncology,2011,12(2):175-180.[17]Korpanty GJ,Graham DM,Vincent MD,et al.Biomarkers That Currently Affect Clinical Practice in Lung Cancer:EGFR, ALK, MET, ROS-1, and KRAS[J].Frontiers in Oncology,2014,4:204.[18]Hirasawa Y,Kohno N,Yokoyama A,et al.KL-6, a human MUC1 mucin, is chemotactic for human fibroblasts[J].American Journal of Respiratory Cell and Molecular Biology,1997,17(4):501-507.[19]Hirasawa Y,Kohno N,Yokoyama A,et al.Natural autoantibody to MUC1 is a prognostic indicator for non-small cell lung cancer[J].American Journal of Respiratory and Critical Care Medicine,2000,161(2 Pt 1):589-594.[20]Farahmand L,Merikhian P,Jalili N,et al.Significant Role of MUC1 in Development of Resistance to Currently Existing Anti-cancer Therapeutic Agents[J].Current Cancer Drug Targets,2018,18(8):737-748.[21]Sato S,Kato T,Abe K,et al.Pre-operative evaluation of circulating KL-6 levels as a biomarker for epithelial ovarian carcinoma and its correlation with tumor MUC1 expression[J].Oncology Letters,2017,14(1):776-786.[22]Namba M,Hattori N,Hamada H,et al.Anti-KL-6/MUC1 monoclonal antibody reverses resistance to trastuzumab-mediated antibody-dependent cell-mediated cytotoxicity by capping MUC1[J].Cancer Letters,2019,442:31-39.[23]Kubo N,Araki K,Yamanaka T,et al.Perioperative management of hepatectomy in patients with interstitial pneumonia:a report of three cases and a literature review[J].Surgery Today,2017,47(10):1173-1179.[24]Horimasu Y,Ishikawa N,Tanaka S, et al.MUC1 in lung adenocarcinoma: cross-sectional genetic and serological study[J].BMC Cancer,2017,17(1):263.[25]Kumar S,Sharawat SK,Ali A,et al.Identification of differentially expressed circulating serum microRNA for the diagnosis and prognosis of Indian non-small cell lung cancer patients[J].Current Problems in Cancer,2020,44(4):100540.[26]Shoji F,Yamazaki K,Kouso H,et al.Predictive Impact for Postoperative Recurrence of Preoperative Serum Krebs von den Lungen-6 Concentration in Pathologic Stage IA Non-Small Cell Lung Cancer[J].The Annals of Thoracic Surgery,2016,101(5):1903-1908.[27]Tanaka S,Hattori N,Ishikawa N,et al.Krebs von den Lungen-6 (KL-6) is a prognostic biomarker in patients with surgically resected nonsmall cell lung cancer[J].International Journal of Cancer,2012,130(2):377-387.[28]Ogawa Y,Ishikawa T,Ikeda K,et al.Evaluation of serum KL-6, a mucin-like glycoprotein, as a tumor marker for breast cancer[J].Clinical Cancer Research,2000,6(10):4069-4072.[29]Xu H,Inagaki Y,Tang W,et al.Elevation of serum KL-6 mucin levels in patients with cholangiocarcinoma[J].Hepato-gastroenterology,2008,55(88):2000-2004.[30]Kimura T,Tanaka S,Haruma K,et al.Clinical significance of MUC1 and E-cadherin expression, cellular proliferation, and angiogenesis at the deepest invasive portion of colorectal cancer[J].International Journal of Oncology,2000,16(1):55-64.[31]Kurosaki M,Izumi N,Onuki Y,et al.Serum KL-6 as a novel tumor marker for hepatocellular carcinoma in hepatitis C virus infected patients[J].Hepatology Research,2005,33(3):250-257.[32]Yamasaki H,Ikeda S,Okajima M,et al.Expression and localization of MUC1, MUC2, MUC5AC and small intestinal mucin antigen in pancreatic tumors[J].International Journal of Oncology,2004,24(1):107-113.

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更新日期/Last Update: 1900-01-01