[1]杨 静,王 新.PD-L1、MMP-9、IMP3表达水平与乳腺癌病理分期、组织学分级及预后的关系研究[J].医学信息,2022,35(14):53-56.[doi:10.3969/j.issn.1006-1959.2022.14.011]
　YANG Jing,WANG Xin.The Relationship Between PD-L1,MMP-9,IMP3 Expression Levels and Pathological Staging,Histological Grade and Prognosis of Breast Cancer[J].Medical Information,2022,35(14):53-56.[doi:10.3969/j.issn.1006-1959.2022.14.011]
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PD-L1、MMP-9、IMP3表达水平与乳腺癌病理分期、组织学分级及预后的关系研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年14期
页码:
53-56
栏目:
论著
出版日期:
2022-07-15

文章信息/Info

Title:
The Relationship Between PD-L1,MMP-9,IMP3 Expression Levels and Pathological Staging,Histological Grade and Prognosis of Breast Cancer
文章编号:
1006-1959（2022）14-0053-04
作者:
杨 静; 王 新
（天津市西青医院病理科，天津 300380）
Author(s):
YANG Jing; WANG Xin
(Department of Pathology,Tianjin Xiqing Hospital,Tianjin 300380,China)
关键词:
PD-L1; MMP-9; IMP3; 乳腺癌; 病理分期; 组织学分级
Keywords:
PD-L1; MMP-9; IMP3; Breast cancer; Pathological staging; Histological grading
分类号:
R737.9
DOI:
10.3969/j.issn.1006-1959.2022.14.011
文献标志码:
A
摘要:
目的 研究乳腺癌组织中程序性死亡受体配体-1（PD-L1）、基质金属蛋白酶9（MMP-9）、胰岛素样生长因子ⅡmRNA结合蛋白3（IMP3）表达水平与患者病理分期、组织学分级及预后的关系。方法 选取2016年7月-2021年7月天津市西青医院收治的60例乳腺癌患者为研究对象，对其术后病理组织行免疫组化检测，观察组织中PD-L1、MMP-9、IMP3的表达情况，并分析其与病理分期、组织学分级及预后的关系。结果 三阴性乳腺癌患者PD-L1、MMP-9、IMP3阳性率高于非三阴性乳腺癌（P＜0.05）；不同病理分期的患者PD-L1、MMP-9、IMP3阳性表达率比较，差异有统计学意义（P＜0.05），其阳性表达率由高至低依次为Ⅳ期＞Ⅲ期＞Ⅱ期＞Ⅰ期；不同组织学分级患者的PD-L1、MMP-9、IMP3阳性表达率比较，差异有统计学意义（P＜0.05），其阳性表达率由高至低依次为3级＞2级＞1级；PD-L1、MMP-9、IMP3阳性患者的乳腺癌预后指数（BCPI）评分高于阴性患者（P＜0.05）；PD-L1、MMP-9、IMP3阳性表达与病理分期、组织学分级及BCPI评分均呈正相关（P＜0.05）。结论 PD-L1、MMP-9、IMP3在三阴性乳腺癌组织中呈高表达，其阳性表达与患者病理分期、组织学分级呈正相关，对患者预后生存具有一定预测价值。
Abstract:
Objective To study the relationship between the expression levels of programmed death receptor ligand-1 (PD-L1), matrix metalloproteinase-9 (MMP-9) and insulin-like growth factor ⅡmRNA-binding protein 3 (IMP3) in breast cancer tissues and pathological staging, histological grading and prognosis of patients.Methods Sixty patients with breast cancer admitted to Tianjin Xiqing Hospital from July 2016 to July 2021 were selected as the research objects. The postoperative pathological tissues were detected by immunohistochemistry. The expressions of PD-L1, MMP-9 and IMP3 in the tissues were observed, and their relationship with pathological stage, histological grade and prognosis was analyzed.Results The positive rates of PD-L1, MMP-9 and IMP3 in patients with triple negative breast cancer were higher than those in patients with non-triple negative breast cancer (P<0.05). There were significant differences in the positive expression rates of PD-L1, MMP-9 and IMP3 among patients with different pathological stages (P<0.05), and the sequence of positive expression rates was stage Ⅳ>stage Ⅲ>stage Ⅱ>stage Ⅰ. There were statistically significant differences in the positive expression rates of PD-L1, MMP-9 and IMP3 among patients with different histological grades (P<0.05), and the positive expression rates were grade 3>grade 2>grade 1 from high to low. The breast cancer prognostic index (BCPI) score in PD-L1, MMP-9 and IMP3 positive patients was higher than that in negative patients (P<0.05). Positive expressions of PD-L1, MMP-9 and IMP3 were positively correlated with pathological stage, histological grade and BCPI score (P<0.05).Conclusion PD-L1, MMP-9 and IMP3 are highly expressed in triple negative breast cancer tissues, and their positive expressions are positively correlated with the pathological stage and histological grade of patients, which has certain predictive value for the prognosis and survival of patients.

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更新日期/Last Update: 1900-01-01