[1]王 嫣,戴 夫,彭 琼.循环纤维蛋白原与白蛋白比值、循环纤维蛋白原与前白蛋白比值联合癌胚抗原对结直肠癌的早期诊断价值[J].医学信息,2022,35(14):75-78.[doi:10.3969/j.issn.1006-1959.2022.14.016]
　WANG Yan,DAI Fu,PENG Qiong.Early Diagnostic Value of Circulating Fibrinogen to Albumin Ratio,Circulating Fibrinogen to Prealbumin Ratio Combined with Carcinoembryonic Antigen in Colorectal Cancer[J].Medical Information,2022,35(14):75-78.[doi:10.3969/j.issn.1006-1959.2022.14.016]
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循环纤维蛋白原与白蛋白比值、循环纤维蛋白原与前白蛋白比值联合癌胚抗原对结直肠癌的早期诊断价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年14期
页码:
75-78
栏目:
论著
出版日期:
2022-07-15

文章信息/Info

Title:
Early Diagnostic Value of Circulating Fibrinogen to Albumin Ratio,Circulating Fibrinogen to Prealbumin Ratio Combined with Carcinoembryonic Antigen in Colorectal Cancer
文章编号:
1006-1959（2022）14-0075-04
作者:
王 嫣; 戴 夫; 彭 琼
（安徽医科大学第三附属医院/合肥市第一人民医院消化内科，安徽 合肥 230000）
Author(s):
WANG Yan; DAI Fu; PENG Qiong
(Department of Gastroenterology,the Third Affiliated Hospital of Anhui Medical University/Hefei First People’s Hospital,Hefei 230000,Anhui,China)
关键词:
纤维蛋白原; 白蛋白; 前白蛋白; 纤维蛋白原与白蛋白比值; 纤维蛋白原与前白蛋白比值
Keywords:
Fibrinogen; Albumin; Prealbumin; Fibrinogen to albumin ratio; Fibrinogen to prealbumin ratio
分类号:
R735.3
DOI:
10.3969/j.issn.1006-1959.2022.14.016
文献标志码:
A
摘要:
目的 探讨应用外周血循环纤维蛋白原与白蛋白比值（FAR）及循环纤维蛋白原与前白蛋白比值（FPR）联合癌胚抗原（CEA）诊断早期结直肠癌的价值。方法 选取2019年6月-2021年6月于我院行手术治疗的初治结直肠患者100例为研究组，另选取同期我院133例结直肠腺瘤性息肉患者为息肉组，体检中心131名健康体检者为对照组，比较三组外周血纤维蛋白原、白蛋白、前白蛋白、FAR、FPR及CEA、糖类抗原199（CA199）水平，通过受试者工作特征曲线（ROC）测定FAR、FPR诊断结直肠癌的临界值，并与CEA、CA199联合诊断，判断FAR、FPR联合CEA、CA199诊断结直肠癌的价值。结果 研究组纤维蛋白原、FAR、FPR、CEA、CA199水平高于息肉组和对照组，差异有统计学意义（P＜0.05）；研究组白蛋白、前白蛋白水平低于息肉组和对照组，差异有统计学意义（P＜0.05）；息肉组纤维蛋白原、FAR、FPR水平高于对照组，差异有统计学意义（P＜0.05）；ROC曲线显示，FAR、FPR单独诊断结直肠癌的敏感度、约登指数、曲线下面积（AUC）均大于CEA、CA199单独诊断，差异有统计学意义（P＜0.05）；FAR、FPR联合CEA、CA199 诊断结直肠癌的敏感度、特异度、约登指数、AUC均高于指标单独诊断，差异有统计学意义（P＜0.05）。结论 应用FAR、FPR对结直肠癌的诊断有较高的敏感性，当FAR、FPR、CEA和CA199联合应用时可显著提高结直肠癌与良性结直肠疾病的诊断效率。
Abstract:
Objective To investigate the value of circulating fibrinogen to albumin ratio (FAR) and circulating fibrinogen to prealbumin ratio (FPR) combined with carcinoembryonic antigen (CEA) in the diagnosis of early colorectal cancer.Methods A total of 100 patients with newly diagnosed colorectal cancer who underwent surgical treatment in our hospital from June 2019 to June 2021 were selected as the study group, and 133 patients with colorectal adenomatous polyps in our hospital during the same period were selected as the polyp group, and 131 healthy people in the physical examination center were selected as the control group. The levels of fibrinogen, albumin, prealbumin, FAR, FPR, CEA and carbohydrate antigen 199 (CA199) in peripheral blood of the three groups were compared. The critical values of FAR and FPR in the diagnosis of colorectal cancer were determined by receiver operating characteristic curve (ROC), and combined with CEA and CA199 to determine the value of FAR and FPR combined with CEA and CA199 in the diagnosis of colorectal cancer.Results The levels of fibrinogen, FAR, FPR, CEA and CA199 in the study group were higher than those in the polyp group and the control group, and the difference was statistically significant (P<0.05). The levels of albumin and prealbumin in the study group were lower than those in the polyp group and the control group, and the difference was statistically significant (P<0.05). The levels of fibrinogen, FAR and FPR in the polyp group were higher than those in the control group, and the difference was statistically significant (P<0.05). ROC curve showed that the sensitivity, Youden index and AUC of FAR and FPR in the diagnosis of colorectal cancer were higher than those of CEA and CA199 alone, and the difference was statistically significant (P<0.05). The sensitivity, specificity, Youden index and AUC of FAR, FPR combined with CEA and CA199 in the diagnosis of colorectal cancer were higher than those of single diagnosis, and the difference was statistically significant (P<0.05).Conclusion FAR and FPR have high sensitivity in the diagnosis of colorectal cancer. The combination of FAR, FPR, CEA and CA199 can significantly improve the diagnostic efficiency of colorectal cancer and benign colorectal diseases.

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更新日期/Last Update: 1900-01-01