[1]袁 野,赵玉祥,潘兆军,等.无创高频通气和经鼻持续正压通气治疗早产儿呼吸窘迫综合征的效果比较[J].医学信息,2022,35(14):79-82.[doi:10.3969/j.issn.1006-1959.2022.14.017]
 YUAN Ye,ZHAO Yu-xiang,PAN Zhao-jun,et al.Comparison of Non-invasive High Frequency Ventilation and Nasal Continuous Positive Pressure Ventilation in the Treatment of Respiratory Distress Syndrome in Premature Infants[J].Medical Information,2022,35(14):79-82.[doi:10.3969/j.issn.1006-1959.2022.14.017]
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无创高频通气和经鼻持续正压通气治疗早产儿呼吸窘迫综合征的效果比较()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年14期
页码:
79-82
栏目:
论著
出版日期:
2022-07-15

文章信息/Info

Title:
Comparison of Non-invasive High Frequency Ventilation and Nasal Continuous Positive Pressure Ventilation in the Treatment of Respiratory Distress Syndrome in Premature Infants
文章编号:
1006-1959(2022)14-0079-04
作者:
袁 野赵玉祥潘兆军
(淮安市妇幼保健院新生儿科,江苏 淮安 223002)
Author(s):
YUAN YeZHAO Yu-xiangPAN Zhao-junet al.
(Department of Neonatal,Huai’an Maternal and Child Health Hospital,Huai’an 223002,Jiangsu,China)
关键词:
呼吸窘迫综合征无创高频通气持续气道正压通气
Keywords:
Respiratory distress syndromeNon-invasive high frequency ventilationNasal continuous positive pressure ventilation
分类号:
R722.6
DOI:
10.3969/j.issn.1006-1959.2022.14.017
文献标志码:
A
摘要:
目的 比较气管插管-使用肺表面活性物质-拔管(INSURE)后予无创高频通气和经鼻持续正压通气治疗早产儿呼吸窘迫综合征(RDS)的临床治疗效果。方法 选择2018年1月-2021年1月淮安市妇幼保健院新生儿科应用INSURE治疗的Ⅱ~Ⅲ级RDS早产儿46例,采用随机数字表法分为改良组21例和传统组25例。比较两组治疗前及治疗后12 h临床指标(pH、PaO2、PaCO2、PaO2/FiO2、无创通气时间、机械通气、需氧和住院时间)及并发症发生情况。结果 改良组治疗后PaCO2低于传统组,pH、PaO2、PaO2/FiO2高于传统组,无创通气时间、需氧时间和住院时间均短于对照组,差异有统计学意义(P<0.05);改良组出生7 d内气管插管机械通气比例低于对照组,差异有统计学意义(P<0.05);但两组需第2剂肺表面活性物质应用、需咖啡因应用、需药物或手术关闭的动脉导管开放、气漏、支气管肺发育不良、腹胀、坏死性小肠结肠炎、自发性肠穿孔、鼻部损伤、Ⅲ~Ⅳ级颅内出血、肺出血、持续肺动脉高压、视网膜病、死亡数比较,差异无统计学意义(P>0.05)。结论 INSURE后予以无创高频通气治疗早产儿Ⅱ~Ⅲ级RDS的效果确切,其可改善患儿呼吸功能,缩短无创通气时间、需氧时间和住院时间,且无其他并发症。
Abstract:
Objective To compare the clinical effects of non-invasive high frequency ventilation and nasal continuous positive pressure ventilation in the treatment of respiratory distress syndrome (RDS) in premature infants after intubation-surfactant-extubation (INSURE).Methods A total of 46 premature infants with grade Ⅱ-Ⅲ RDS treated with INSURE in Department of Neonatology, Huai’an Maternal and Child Health Hospital from January 2018 to January 2021 were selected and randomly divided into modified group (n=21) and traditional group (n=25). The clinical indexes (pH, PaO2, PaCO2, PaO2/FiO2, noninvasive ventilation time, mechanical ventilation, oxygen demand and hospitalization time) and complications were compared between the two groups before and 12 h after treatment.Results After treatment, PaCO2 in the modified group was lower than that in the traditional group, pH, PaO2 and PaO2/FiO2 were higher than those in the traditional group, noninvasive ventilation time, oxygen demand time and hospitalization time were shorter than those in the control group, the difference was statistically significant (P<0.05). The proportion of endotracheal intubation mechanical ventilation within 7 days of birth in the improved group was lower than that in the control group, and the difference was statistically significant (P<0.05). There was no significant difference between the two groups in the application of the second dose of pulmonary surfactant, caffeine, drug or surgical closure of the patent ductus arteriosus, air leakage, bronchopulmonary dysplasia, abdominal distension, necrotizing enterocolitis, spontaneous intestinal perforation, nasal injury, grade III-IV intracranial hemorrhage, pulmonary hemorrhage, persistent pulmonary hypertension, retinopathy and death (P>0.05).Conclusion The effect of non-invasive high-frequency ventilation after INSURE in the treatment of premature infants with grade Ⅱ-Ⅲ RDS is accurate, which can improve the respiratory function of children, shorten the non-invasive ventilation time, oxygen demand time and hospitalization time, and has no other complications.

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更新日期/Last Update: 1900-01-01