[1]熊永崂,孙晓燕,聂晓莉,等.卵泡期半量长方案在反复种植失败患者再次行IVF-ET治疗中的疗效[J].医学信息,2022,35(14):116-118.[doi:10.3969/j.issn.1006-1959.2022.14.028]
　XIONG Yong-lao,SUN Xiao-yan,NIE Xiao-li,et al.Efficacy of Follicular Half-dose Long Protocol in Repeated IVF-ET for Patients with Failed Implantation[J].Medical Information,2022,35(14):116-118.[doi:10.3969/j.issn.1006-1959.2022.14.028]
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卵泡期半量长方案在反复种植失败患者再次行IVF-ET治疗中的疗效()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年14期
页码:
116-118
栏目:
药物与临床
出版日期:
2022-07-15

文章信息/Info

Title:
Efficacy of Follicular Half-dose Long Protocol in Repeated IVF-ET for Patients with Failed Implantation
文章编号:
1006-1959（2022）14-0116-03
作者:
熊永崂; 孙晓燕; 聂晓莉; 等
（1.珠海市妇幼保健院生殖医学中心，广东 珠海 519000；2.中山大学附属第六医院生殖中心，广东 广州 510000）
Author(s):
XIONG Yong-lao; SUN Xiao-yan; NIE Xiao-li; et al.
(1.Medical Center of Reproduction,Zhuhai Maternity and Child Health Hospital,Zhuhai 519000,Guangdong,China;2.Reproductive Center of the Sixth Affiliated Hospital of Sun Yat-sen University,Guangzhou 510000,Guangdong,China)
关键词:
促性腺激素释放激素激动剂; 反复种植失败; 体外受精-胚胎移植
Keywords:
Gonadotropin-releasing hormone agonist; Recurrent implantation failure; In-vitro fertilization-embryo transfer
分类号:
R711.6
DOI:
10.3969/j.issn.1006-1959.2022.14.028
文献标志码:
A
摘要:
目的 探讨卵泡期半量长方案在反复种植失败患者再次行IVF-ET治疗中的应用效果。方法 收集2020年1月-12月珠海市妇幼保健院生殖医学中心收治的反复种植失败再次行IVF-ET治疗的患者160例，根据促性腺激素释放激素激动剂（GnRH-a）使用剂量不同分成研究组和对照组，每组80例。研究组予以卵泡期半量长方案，对照组予以卵泡期长方案，比较两组激素水平、促排卵情况及IVF-ET结局。结果 两组基础状态下FSH、LH、E2水平，启动日FSH、E2水平，hCG日P水平比较，差异无统计学意义（P＞0.05），研究组启动日和hCG日LH、hCG日E2水平高于对照组（P＜0.05）；研究组Gn天数、Gn总量少于对照组，获卵数、2PN受精率高于对照组（P＜0.05）；两组hCG日内膜厚度、周期取消率比较，差异无统计学意义（P＞0.05）；研究组妊娠率、种植率高于对照组（P＜0.05）；两组平均移植胚胎数、流产率比较，差异无统计学意义（P＞0.05）。结论 卵泡期半量长方案在不降低子宫内膜容受性的同时，可改善反复种植失败患者胚胎的质量，提高胚胎的种植率和临床妊娠率。
Abstract:
Objective To investigate the application effect of follicular half-dose long protocol in repeated IVF-ET treatment for patients with recurrent implantation failure.Methods A total of 160 patients with repeated implantation failure who received IVF-ET treatment again in the Medical Center of Reproduction,Zhuhai Maternity and Child Health Hospital from January to December 2020 were collected and divided into study group and control group according to different doses of gonadotropin-releasing hormone agonist (GnRH-a), with 80 cases in each group. The study group was given a half-dose follicular phase scheme, and the control group was given a long-dose follicular phase scheme. The hormone levels, ovulation induction and IVF-ET outcomes of the two groups were compared.Results There was no significant difference in the levels of FSH, LH and E2 at baseline, FSH and E2 at initiating day and P level at hCG day between the two groups (P>0.05); the levels of LH and E2 at initiating day and HCG day in the study group were higher than those in the control group (v<0.05). The days of Gn and the total amount of Gn in the study group were less than those in the control group, and the number of oocytes obtained and the fertilization rate of 2PN in the study group were higher than those in the control group(P<0.05); there was no significant difference in endometrial thickness on hCG day and cycle cancellation rate between the two groups (P>0.05). The pregnancy rate and planting rate in the study group were higher than those in the control group (P<0.05); there was no significant difference in the average number of transplanted embryos and abortion rate between the two groups (P>0.05).Conclusion Half-dose follicle phase long protocol can increase embryo implanting rate and clinical pregnancy rate by improving embryo quality while not reducing endometrial receptivity in patients with recurrent implantation failure.

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更新日期/Last Update: 1900-01-01