[1]赵晓静,鲁作华,韩书光,等.同型半胱氨酸、C反应蛋白及心肌标志物与冠心病早期诊断的相关研究[J].医学信息,2022,35(14):135-137.[doi:10.3969/j.issn.1006-1959.2022.14.034]
 ZHAO Xiao-jing,LU Zuo-hua,HAN Shu-guang,et al.Correlation of Homocysteine, C-reactive Protein and Myocardial Markers with Early Diagnosis of Coronary Heart Disease[J].Medical Information,2022,35(14):135-137.[doi:10.3969/j.issn.1006-1959.2022.14.034]
点击复制

同型半胱氨酸、C反应蛋白及心肌标志物与冠心病早期诊断的相关研究()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年14期
页码:
135-137
栏目:
诊疗技术
出版日期:
2022-07-15

文章信息/Info

Title:
Correlation of Homocysteine, C-reactive Protein and Myocardial Markers with Early Diagnosis of Coronary Heart Disease
文章编号:
1006-1959(2022)14-0135-03
作者:
赵晓静鲁作华韩书光
(上海市浦东新区公利医院检验科,上海 200135)
Author(s):
ZHAO Xiao-jingLU Zuo-huaHAN Shu-guanget al.
(Department of Clinical Laboratory,Shanghai Pudong New Area Gongli Hospital,Shanghai 200135,China)
关键词:
冠心病同型半胱氨酸C反应蛋白心肌标志物
Keywords:
Coronary heart diseaseHomocysteineC-reactive proteinMyocardial marker
分类号:
R541.4
DOI:
10.3969/j.issn.1006-1959.2022.14.034
文献标志码:
A
摘要:
目的 探讨血液指标同型半胱氨酸(HCY)、C反应蛋白(CRP)以及心肌标志物与冠心病早期诊断的相关性。方法 选取2020年8月-2021年3月在上海市浦东新区公利医院诊断的102例冠心病患者作为观察组,将其再分为心绞痛(AP)组88例和心肌梗死(AMI)组14例。另选取同时期就诊我院的健康体检者60例作为对照组。比较观察组初诊时与对照组血液中HCY、CRP以及心肌标志物的浓度水平,探究其与冠心病诊断的相关性。结果 观察组HCY、CRP、TNI、CK-MB、MYO的血液浓度水平均高于对照组,差异有统计学意义(P<0.05);AMI组TNI、CK-MB、MYO的血液浓度水平均高于AP组,差异有统计学意义(P<0.05)。结论 血浆HCY、CRP、TNI、CK-MB、MYO水平与早期冠心病有密切关系,并且有助于判断冠心病的病变程度。
Abstract:
Objective To investigate the correlation between blood homocysteine (HCY), C-reactive protein (CRP), myocardial markers and early diagnosis of coronary heart disease.Methods A total of 102 patients with coronary heart disease diagnosed in Shanghai Pudong New Area Gongli Hospital, from August 2020 to March 2021 were selected as the observation group. They were divided into angina pectoris (AP) group (88 cases) and myocardial infarction (AMI) group (14 cases). In addition, 60 healthy people who visited our hospital in the same period were selected as the control group. The concentrations of HCY, CRP and myocardial markers in the blood of the observation group and the control group at the first diagnosis were compared to explore their correlation with the diagnosis of coronary heart disease.Results The blood concentration levels of HCY, CRP, TNI, CK-MB and MYO in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.05). The blood concentrations of TNI, CK-MB and MYO in AMI group were higher than those in AP group, and the difference was statistically significant(P<0.05).Conclusion Plasma HCY, CRP, TNI, CK-MB, MYO levels are closely related to early coronary heart disease, and help to determine the severity of coronary heart disease.

参考文献/References:

[1]沙吉旦·阿不都热衣木,帕丽达·阿布来提,艾扎提丽·卡的尔,等.冠心病病人同型半胱氨酸与D-二聚体、凝血指标的相关性分析[J].中西医结合心脑血管病杂志,2020,18(19):3238-3241.[2]胡盛寿,高润霖,刘力生,等.《中国心血管病报告2018》概要[J].中国循环杂志,2019,34(3):209-220.[3]Zheng X,Curtis JP,Hu S,et al.Coronary Catheterization and Percutaneous Coronary Intervention in China: 10-Year Results From the China PEACE-Retrospective CathPCI Study[J].JAMA Internal Medicine,2016,176(4):512-521.[4]国家心血管病中心.中国心血管健康与疾病报告2020[J].心肺血管病杂志,2021,40(9):885-889.[5]王晓虎,张进,谢宏涛,等.128层螺旋CT冠状动脉成像及冠脉造影在诊断冠心病中的对照研究[J].中国CT和MRI杂志,2020,18(12):61-63.[6]徐玲,尹婷婷.冠心病冠状动脉粥样硬化发生的危险因素多因素Logistic分析[J].临床和实验医学杂志,2019,18(6):626-629.[7]Ganguly P,Alam SF.Role of homocysteine in the development of cardiovascular disease[J].Nutr J,2015,14:6.[8]孟广艳,鲍会漳,秦莉,等.同型半胱氨酸水平与冠心病的发生发展的相关性研究[J].中国实验诊断学,2021,25(8):1112-1116.[9]Raffield LM,Ellis J,Olson NC,et al.Genome-wide association study of homocysteine in African Americans from the Jackson Heart Study,the Multi-Ethnic Study of Atherosclerosis, and the Coronary Artery Risk in Young Adults study[J].J Hum Genet,2018,63(3):327-337.[10]Karolczak K,Kubalczyk P,Glowacki R,et al.Aldosterone modulatesblood homocysteine and cholesterol in coronary artery diseasepatients - a possible impact on atherothrombosis[J].Physiol Res,2018,67(2):197-207.[11]葛婕丽,黄淑田,姚冰琪,等.血清胆红素和同型半胱氨酸水平变化与冠心病临床类型的关系分析[J].临床医药实践,2020,29(6):422-424,456.[12]张芳芹.降同型半胱氨酸疗法在冠心病介入治疗中的应用效果[J].临床合理用药杂志,2020,13(16):38-40.[13]董茜,韩晓涛,陈永福,等.不同类型冠心病患者血清Hcy、TBIL、hs-CRP、尿酸的表达及临床意义[J].现代生物医学进展,2020,20(9):1669-1672.[14]Taskesen T,Sekhon H,Wroblewski I,et al.Usefulness of Mean Platelet Volume to Predict Significant Coronary Artery Disease in Patients With Non-ST-Elevation Acute Coronary Syndromes[J].Am J Cardiol,2017,119(2):192-196.[15]程小兵,潘文博,钟万生,等.超敏C反应蛋白和同型半胱氨酸与原发性高血压患者血压变异性的关系研究[J].临床心血管病杂志,2016,32(3):277-279.[16]张潇月,张薇,王义霞,等.急性心肌梗死急诊介入治疗后血清铁蛋白、超敏C反应蛋白、肌钙蛋白、脑钠肽及低密度脂蛋白的变化及意义[J].国际麻醉学与复苏杂志,2017,38(10):886-890.[17]王新成,郭游行,惠会婷,等.血浆Lp-pLA2、cTnⅠ、HCY水平与冠心病合并高脂血症患者冠脉病变程度的相关性研究[J].实用预防医学,2019,26(2):208-210.[18]张慧霞,张超红.主动脉球囊反搏联合急诊PCI对急性心肌梗死合并心源性休克病人术后血清cTnⅠ、NSE、PCT水平及生存质量的影响[J].中西医结合心脑血管病杂志,2019,17(5):748-751.[19]马小兰,盛秀红,吴凡,等.联合检测Myo、cTnⅠ、IL-6、hs-CRP在急性心梗中的临床应用[J].甘肃科学学报,2017,29(6):61-64.[20]王延庆,韩玉珍,黄立锋.血清肌红蛋白监测的临床意义[J].实用医学杂志,2019,35(24):3859-3863.[21]姚磊.心肌损伤标志物对急性心肌梗死早期诊断的意义[J].实用检验医师杂志,2019,11(1):26-29.

相似文献/References:

[1]张挺挺.经股和桡动脉介入治疗冠心病的临床疗效对比[J].医学信息,2018,31(03):114.[doi:10.3969/j.issn.1006-1959.2018.03.038]
 ZHANG Ting-ting.Comparison of Clinical Effects of Interventional Treatment of Coronary Heart Disease by Femoral and Radial Artery[J].Medical Information,2018,31(14):114.[doi:10.3969/j.issn.1006-1959.2018.03.038]
[2]迮艳华.稳心颗粒联合美托洛尔治疗冠心病心律失常的疗效分析[J].医学信息,2018,31(03):139.[doi:10.3969/j.issn.1006-1959.2018.03.049]
 ZE Yan-hua.Therapeutic Effect of Wenxin Granule Combined with Metoprolol on Arrhythmia of Coronary Heart Disease[J].Medical Information,2018,31(14):139.[doi:10.3969/j.issn.1006-1959.2018.03.049]
[3]张 旭.冠心病心绞痛患者进行护理干预的临床效果及 对护理质量影响研究[J].医学信息,2018,31(05):182.[doi:10.3969/j.issn.1006-1959.2018.05.068]
 ZHANG Xu.Clinical Effect of Nursing Intervention in Patients with Angina Pectoris of Coronary Heart Disease and its Influence on Nursing Quality[J].Medical Information,2018,31(14):182.[doi:10.3969/j.issn.1006-1959.2018.05.068]
[4]向明明,赵晓辉.黑龙江省东部地区汉族人群冠心病的危险因素研究[J].医学信息,2018,31(07):122.[doi:10.3969/j.issn.1006-1959.2018.07.041]
 XIANG Ming-ming,ZHAO Xiao-hui.Study on Risk Factors of Coronary Heart Disease in Han Nationality Population in Eastern Heilongjiang Province[J].Medical Information,2018,31(14):122.[doi:10.3969/j.issn.1006-1959.2018.07.041]
[5]王 坤,张永春.血清胆红素水平、单核细胞数、红细胞分布宽度与 冠状动脉病变程度的关系[J].医学信息,2018,31(08):53.[doi:10.3969/j.issn.1006-1959.2018.08.017]
 WANG Kun,ZHANG Yong-chun.Relationship between Serum Bilirubin Level,Monocyte Count,Red Blood Cell Distribution Width and Severity of Coronary Artery Disease[J].Medical Information,2018,31(14):53.[doi:10.3969/j.issn.1006-1959.2018.08.017]
[6]毛红岩.冠状动脉介入治疗冠心病的疗效及 对患者血清炎症因子的影响[J].医学信息,2018,31(10):77.[doi:10.3969/j.issn.1006-1959.2018.10.023]
 MAO Hong-yan.Effect of Coronary Intervention on Coronary Heart Disease and its Influence on Serum Inflammatory Factors[J].Medical Information,2018,31(14):77.[doi:10.3969/j.issn.1006-1959.2018.10.023]
[7]杨锦龙,刘 欢,吕秋菊,等.非糖尿病患者糖化血红蛋白和胰岛素抵抗与 冠状动脉病变程度的相关性研究[J].医学信息,2018,31(10):93.[doi:10.3969/j.issn.1006-1959.2018.10.028]
 YANG Jin-long,LIU Huan,LV Qiu-ju,et al.Correlation between Glycosylated Hemoglobin and Insulin Resistance and Severity of Coronary Artery Disease in Non-diabetic Patients[J].Medical Information,2018,31(14):93.[doi:10.3969/j.issn.1006-1959.2018.10.028]
[8]李 铎,王建华.盐酸曲美他嗪片辅助治疗对冠心病伴心力衰竭患者氧化应激、心肌功能的影响[J].医学信息,2018,31(10):126.[doi:10.3969/j.issn.1006-1959.2018.10.041]
 LI Duo,WANG Jian-hua.Effect of Trimetazidine Hydrochloride Tablets Adjuvant Therapy on Oxidative Stress and Myocardial Function in Patients with Coronary Heart Disease Complicated with Heart Failure[J].Medical Information,2018,31(14):126.[doi:10.3969/j.issn.1006-1959.2018.10.041]
[9]田跃雷.冠心病介入治疗后再狭窄的中西医防治[J].医学信息,2022,35(09):46.[doi:10.3969/j.issn.1006-1959.2022.09.011]
 TIAN Yue-lei.Prevention and Treatment of Restenosis After Percutaneous Coronary Intervention with Chinese and Western Medicine[J].Medical Information,2022,35(14):46.[doi:10.3969/j.issn.1006-1959.2022.09.011]
[10]宫丽萍.血府逐瘀汤加减治疗气滞血瘀型冠心病心绞痛的疗效研究[J].医学信息,2018,31(12):145.[doi:10.3969/j.issn.1006-1959.2018.12.046]
 GONG Li-ping.Therapeutic Effect of Xuefu Zhuyu Decoction on Angina Pectoris with Qi Stagnation and Blood Stasis[J].Medical Information,2018,31(14):145.[doi:10.3969/j.issn.1006-1959.2018.12.046]
[11]袁 帅,邢晓博,李 晓,等.MTHFR基因多态性与中年男性冠状动脉病变程度的相关研究[J].医学信息,2018,31(03):67.[doi:10.3969/j.issn.1006-1959.2018.03.021]
 YUAN Shuai,XING Xiao-bo,LI Xiao,et al.Association of MTHFR Gene Polymorphism with Coronary Artery Lesions in Middle-aged Men[J].Medical Information,2018,31(14):67.[doi:10.3969/j.issn.1006-1959.2018.03.021]
[12]张 波.冠心病心绞痛患者血浆同型半胱氨酸水平与 中医证候要素痰、瘀的回归性研究[J].医学信息,2018,31(16):142.[doi:10.3969/j.issn.1006-1959.2018.16.045]
 ZHANG Bo.A Regression Study of Plasma Homocysteine Level and Phlegm and Blood Stasis in Patients with Angina Pectoris of Coronary Heart Disease[J].Medical Information,2018,31(14):142.[doi:10.3969/j.issn.1006-1959.2018.16.045]
[13]张晓瑛,李雯彬,张志虹,等.同型半胱氨酸、抑郁症状与冠心病的研究进展[J].医学信息,2019,32(11):22.[doi:10.3969/j.issn.1006-1959.2019.11.007]
 ZHANG Xiao-ying,LI Wen-bin,ZHANG Zhi-hong,et al.Advances in Research on Homocysteine,Depressive Symptoms and Coronary Heart Disease[J].Medical Information,2019,32(14):22.[doi:10.3969/j.issn.1006-1959.2019.11.007]
[14]周忠梅.前列地尔辅助常规治疗冠心病不稳定型心绞痛的效果及对患者凝血功能的影响[J].医学信息,2019,32(20):147.[doi:10.3969/j.issn.1006-1959.2019.20.046]
 ZHOU Zhong-mei.Effect of Alprostadil on Routine Treatment of Unstable Angina Pectoris in Coronary Heart Disease and its Effect on Coagulation Function in Patients[J].Medical Information,2019,32(14):147.[doi:10.3969/j.issn.1006-1959.2019.20.046]
[15]张盼盼,薛 凌.PCSK9及Hcy水平对冠心病患者的临床意义[J].医学信息,2020,33(08):73.[doi:10.3969/j.issn.1006-1959.2020.08.024]
 ZHANG Pan-pan,XUE Ling.Clinical Significance of PCSK9 and Hcy Levels in Patients with Coronary Heart Disease[J].Medical Information,2020,33(14):73.[doi:10.3969/j.issn.1006-1959.2020.08.024]
[16]陈路阳,常 静,毛 敏.同型半胱氨酸与冠心病的相关性[J].医学信息,2020,33(09):50.[doi:10.3969/j.issn.1006-1959.2020.09.016]
 CHEN Lu-yang,CHANG Jing,MAO Min.Correlation Between Homocysteine and Coronary Heart Disease[J].Medical Information,2020,33(14):50.[doi:10.3969/j.issn.1006-1959.2020.09.016]

更新日期/Last Update: 1900-01-01