[1]贾科锋,魏召劝,郭亚堂,等.阿哌沙班与低分子肝素钠在膝关节置换术后抗凝治疗的对比[J].医学信息官方网站,2022,35(15):55-58.[doi:10.3969/j.issn.1006-1959.2022.15.011]
 JIA Ke-feng,WEI Zhao-quan,GUO Ya-tang,et al.Comparison of Anticoagulant Therapy Between Apixaban and Low Molecular Heparin Sodium After Knee Arthroplasty[J].Medical Information,2022,35(15):55-58.[doi:10.3969/j.issn.1006-1959.2022.15.011]
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阿哌沙班与低分子肝素钠在膝关节置换术后抗凝治疗的对比()
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《医学信息》官方网站[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年15期
页码:
55-58
栏目:
论著
出版日期:
2022-08-01

文章信息/Info

Title:
Comparison of Anticoagulant Therapy Between Apixaban and Low Molecular Heparin Sodium After Knee Arthroplasty
文章编号:
1006-1959(2022)15-0055-04
作者:
贾科锋魏召劝郭亚堂
(1.华北医疗健康集团邢台总医院关节外科,河北 邢台 054000;2.邢台市第一医院骨科,河北 邢台 054000;3.邢台市第三医院骨科,河北 邢台 054000)
Author(s):
JIA Ke-fengWEI Zhao-quanGUO Ya-tanget al.
(1.Department of Joint Surgery,North China Medical Heath Group Xingtai General Hospital,Xingtai 054000,Hebei,China;2.Department of Orthopedics,the First Hospital of Xingtai,Xingtai 054000,Hebei,China;3.Department of Orthopedics,the Third Hospital of Xingtai,Xingtai 054000,Hebei,China)
关键词:
阿哌沙班低分子肝素钙膝关节置换术深静脉血栓
Keywords:
ApixabanLow molecular weight heparin calciumKnee arthroplastyDeep vein thrombosis
分类号:
R687.4+2
DOI:
10.3969/j.issn.1006-1959.2022.15.011
文献标志码:
A
摘要:
目的 比较阿哌沙班与低分子肝素钙(LMWH)在膝关节置换术后抗凝治疗中的临床效果。方法 选取2020年1月-12月在华北医疗健康集团邢台总医院行膝关节置换患者220例,采用随机数字表法分为A组和B组,各110例。A组于术后12 h口服阿哌沙班抗凝治疗,B组于术后12 h皮下注射低分子肝素钙抗凝治疗。比较两组血红蛋白变化量、膝关节周径、D-二聚体值、下肢静脉血栓发生率。结果 A组术后7 d血红蛋白变化量少于B组,膝关节周径小于B组,差异有统计学意义(P<0.05);两组手术前后D-二聚体值比较,差异无统计学意义(P>0.05);A组术后1 d下肢静脉血栓发生率为4.55%,与B组的3.60%比较,差异无统计学意义(P>0.05)。结论 阿哌沙班与低分子肝素钙在预防膝关节置换术后下肢静脉血栓中的效果相当,但阿哌沙班在下肢肿胀、失血量方面优于低分子肝素钙。
Abstract:
Objective To compare the clinical effects of apixaban and low molecular weight heparin calcium (LMWH) in anticoagulant therapy after knee arthroplasty.Methods A total of 220 patients undergoing knee arthroplasty in North China Medical Heath Group Xingtai General Hospital from January to December 2020 were selected and randomly divided into group A and group B, with 110 cases in each group. Group A was treated with oral administration of apixaban at 12 h after operation, and group B was treated with subcutaneous injection of low molecular weight heparin calcium at 12 h after operation. Hemoglobin change, knee circumference, D-dimer value and incidence of lower extremity venous thrombosis were compared between the two groups.Results The change of hemoglobin in group A at 7 d after operation was less than that in group B, and the circumference of knee joint was less than that in group B, the difference was statistically significant (P<0.05). There was no significant difference in D-dimer values between the two groups before and after surgery (P>0.05). One day after operation, the incidence of venous thrombosis of lower limbs in group A was 4.55%, which was compared with 3.60% in group B, the difference was not statistically significant (P>0.05).Conclusion Apixaban is similar to low molecular weight heparin calcium in the prevention of lower extremity venous thrombosis after knee arthroplasty, but apixaban is superior to low molecular weight heparin calcium in lower extremity swelling and blood loss.

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更新日期/Last Update: 1900-01-01