[1]刘海珍.丙种球蛋白应用时间对川崎病患儿退热时间及冠状动脉损伤的影响[J].医学信息,2022,35(16):73-75.[doi:10.3969/j.issn.1006-1959.2022.16.016]
　LIU Hai-zhen.The Effect of Application Time of Intravenous Immune Globulin on Fever Clearance Time and Coronary Artery Lesion for Kawasaki Disease[J].Journal of Medical Information,2022,35(16):73-75.[doi:10.3969/j.issn.1006-1959.2022.16.016]
点击复制

丙种球蛋白应用时间对川崎病患儿退热时间及冠状动脉损伤的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年16期
页码:
73-75
栏目:
论著
出版日期:
2022-08-15

文章信息/Info

Title:
The Effect of Application Time of Intravenous Immune Globulin on Fever Clearance Time and Coronary Artery Lesion for Kawasaki Disease
文章编号:
1006-1959（2022）16-0073-03
作者:
刘海珍
（于都县妇幼保健院儿科，江西 于都 342301）
Author(s):
LIU Hai-zhen
(Department of Pediatrics,Yudu County Maternal and Child Health Hospital,Yudu 342301,Jiangxi,China)
关键词:
丙种球蛋白; 川崎病; 退热时间; 冠状动脉损伤
Keywords:
Gamma globulin; Kawasaki disease; Antipyretic time; Coronary artery injury
分类号:
R725.4
DOI:
10.3969/j.issn.1006-1959.2022.16.016
文献标志码:
A
摘要:
目的 研究丙种球蛋白应用时间对川崎病患儿退热时间及冠状动脉损伤的影响。方法 选取2018年1月-2021年7月我院接诊的74例川崎病患儿为研究对象，采用随机数字表法分为对照组和观察组，各37例。对照组于病程10 d后给予丙种球蛋白治疗，观察组于病程1~10 d内给予丙种球蛋白治疗，比较两组临床疗效、临床症状消退时间、炎性水平[血小板计数（PCT）、白细胞计数（WBC）、C反应蛋白（CRP）]、并发症发生率以及不良反应发生率。结果 观察组治疗总有效率为94.59%，高于对照组的83.78%，差异有统计学意义（P＜0.05）；观察组退热、皮疹、手足肿胀、颈部淋巴结肿大消退时间均短于对照组，差异有统计学意义（P＜0.05）；两组治疗后PCT、WBC、CRP均低于治疗前（P＜0.05），但组间比较，差异无统计学意义（P＞0.05）；观察组冠状动脉扩张、冠状动脉瘤发生率均低于对照组，差异有统计学意义（P＜0.05）；两组不良反应发生率比较，差异无统计学意义（P＞0.05）。结论 在病程1~10 d给予丙种球蛋白治疗川崎病的效果理想，可缩短临床症状消退时间，减轻炎症反应，预防冠状动脉损伤的发生，且不良反应发生率较低，安全性较高。
Abstract:
Objective To study the effect of gamma globulin application time on antipyretic time and coronary artery injury in children with Kawasaki disease.Methods A total of 74 children with Kawasaki disease admitted to our hospital from January 2018 to July 2021 were selected as the research objects. They were divided into control group and observation group by random number table method, with 37 cases in each group. The control group was treated with gamma globulin at 10 days after the course of disease, and the observation group was treated with gamma globulin at 1-10 days after the course of disease. The clinical efficacy, clinical symptom regression time, inflammatory level [platelet count (PCT), white blood cell count (WBC), C-reactive protein (CRP)], incidence of complications and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 94.59%, which was higher than 83.78% in the control group, and the difference was statistically significant (P<0.05). The disappearance time of fever, rash, hand and foot swelling and cervical lymph node enlargement in the observation group were shorter than those in the control group, differences being significant (P<0.05). After treatment, PCT, WBC and CRP in the two groups were lower than those before treatment (P<0.05), but there was no significant difference between the two groups (P>0.05). The incidence of coronary artery dilatation and coronary artery aneurysm in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the observation group and the control group (P>0.05).Conclusion In the course of 1-10 days given gamma globulin treatment of Kawasaki disease effect is ideal, which can shorten the clinical symptoms subside time, reduce inflammation, prevent the occurrence of coronary artery injury, and the incidence of adverse reactions is low, with high safety.

参考文献/References:

[1]闵锋,朱少元,李娇春,等.丙种球蛋白应用时间对川崎病患儿退热时间以及冠状动脉损伤的影响[J].东南大学学报(医学版),2016,35(1):50-53.[2]褚馨远,陈希,李奇蕊,等.儿童复发川崎病的临床分析[J].中国小儿急救医学,2021,28(9):806-809.[3]周艳茹,霍黎,葛娇.不同剂量免疫球蛋白治疗小儿川崎病的临床分析[J].河北医药,2018,40(2):258-260. [4]郭武强,沈明珍,陈祥海,等.不同剂量丙种球蛋白治疗小儿川崎病的临床疗效[J].吉林医学,2017,38(4):716-717.[5]孔占一,廖巧琴,赵妗.丙种球蛋白应用时间对川崎病患儿退热时间以及冠状动脉损伤的影响[J].医学理论与实践,2021,34(8):1375-1377.[6]郑丽萍.不同剂量丙种球蛋白治疗小儿川崎病的效果观察[J].齐齐哈尔医学院学报,2016,37(31):3905-3906.[7]何胜男,唐雪梅,张宇,等.川崎病相关巨噬细胞活化综合征临床分析及诊断标准初探[J].中华实用儿科临床杂志,2018,33(9):679-683.[8]钱颖,王有成,方晓丹,等.大剂量丙种球蛋白联合阿司匹林对川崎病患儿T淋巴细胞亚群、血管内皮因子、炎症因子水平的影响[J].中华全科医学,2017,15(3):454-456.[9]张英谦,郝京霞,李博,等.静脉用丙种球蛋白治疗川崎病的时机和临床效果分析[J].中国医药,2021,16(2):204-207.[10]赵春娜,杜忠东,高灵灵,等.川崎病儿童冠状动脉病变危险因素分析[J].中华实用儿科临床杂志,2016,31(9):659-661.[11]江雅静,赵玉岐,王鹤,等.血清NT-proBNP与IL-6在川崎病患儿水平变化及临床意义[J].实用预防医学,2018,25(2):199-201,245.[12]汪燕,鲁利群,贺静,等.川崎病患儿炎症因子和免疫功能指标检测的临床意义[J].儿科药学杂志,2018,24(1):4-7.[13]范江花,段蔚,罗海燕,等.血浆N端脑利钠肽前体和降钙素原对早期川崎病冠状动脉损害的预测价值[J].儿科药学杂志,2018,24(9):5-9.[14]江佳峪,赵世权,高小平.不同途径给予激素治疗丙种球蛋白无反应型川崎病临床观察[J].解放军医药杂志,2019,31(1):63-66.[15]胡蓉,潘云波,甘世伟.川崎病初始剂量丙种球蛋白治疗敏感或无反应的相关因素分析[J].中国妇幼健康研究,2017,28(12):1642-1645.[16]熊瑛.丙种球蛋白应用时间对川崎病患儿退热时间及冠状动脉损伤的影响价值[J].中外医学研究,2019,17(24):30-32.[17]李秀云,黄从付,罗建军.丙种球蛋白无反应型川崎病的药物治疗情况分析[J].中国医药科学,2017,7(21):242-244.[18]杜军保,陈咏冰.川崎病丙种球蛋白无反应型的预测及治疗[J].北京大学学报(医学版),2017,49(5):749-752.[19]Mohammadzadeh I,Noei S,Babazadeh K,et al.Comparison of early and late intravenous gamma globulin treatment of Kawasaki disease on fever and cardiovascular complications[J].Caspian J Intern Med,2016,7(3):211-216.

相似文献/References:

[1]覃 艺,邓燕艺,赖昌生,等.手足口病患儿体内免疫球蛋白、补体、C反应蛋白及刺激分析CD80、CD86水平的临床意义及其与丙种球蛋白治疗疗效的关系[J].医学信息,2018,31(02):63.[doi:10.3969/j.issn.1006-1959.2018.02.022]
　Qin Yi,DENG Yan-yi,LAI Chang-sheng,et al.Clinical Significance of Immunoglobulin,Complement,C-reactive Protein and CD80,CD86 in Children with Hand-foot-mouth Disease and their Relationship with Therapeutic Effect of Gamma Globulin[J].Journal of Medical Information,2018,31(16):63.[doi:10.3969/j.issn.1006-1959.2018.02.022]
[2]孙昌瑞,冯 林.心肌标志物联合检测对川崎病早期诊断的临床意义[J].医学信息,2019,32(08):113.[doi:10.3969/j.issn.1006-1959.2019.08.032]
　SUN Chang-rui,FENG Lin.Clinical Significance of Combined Detection of Myocardial Markers in Early Diagnosis of Kawasaki Diseases[J].Journal of Medical Information,2019,32(16):113.[doi:10.3969/j.issn.1006-1959.2019.08.032]
[3]黄 铃,孙 冰,蔡金美,等.维生素D治疗川崎病的疗效及其对血清促炎因子的影响[J].医学信息,2019,32(18):81.[doi:10.3969/j.issn.1006-1959.2019.18.025]
　HUANG Ling,SUN Bing,CAI Jin-mei,et al.Therapeutic Effect of Vitamin D on Kawasaki Disease and Its Effect on Serum Pro-inflammatory Factors[J].Journal of Medical Information,2019,32(16):81.[doi:10.3969/j.issn.1006-1959.2019.18.025]
[4]林 婷.纤维支气管镜肺泡灌洗联合丙种球蛋白治疗小儿重症肺炎的疗效及对炎症因子的影响[J].医学信息,2022,35(22):79.[doi:10.3969/j.issn.1006-1959.2022.22.014]
　LIN Ting.Therapeutic Effect of Bronchoalveolar Lavage Combined with Gamma Globulinon Severe Pneumonia in Children and its Influence on Inflammatory Factors[J].Journal of Medical Information,2022,35(16):79.[doi:10.3969/j.issn.1006-1959.2022.22.014]
[5]喻 明,李 莹,王秀容.甲泼尼龙联合丙种球蛋白治疗抗NMDAR型脑炎的疗效及对患者精神症状的影响[J].医学信息,2021,34(15):159.[doi:10.3969/j.issn.1006-1959.2021.15.044]
　YU Ming,LI Ying,WANG Xiu-rong.Efficacy of Methylprednisolone Combined with Gamma Globulin in the Treatment of Anti-NMDAR Encephalitis and Its Effect on Patient’s Mental Symptoms[J].Journal of Medical Information,2021,34(16):159.[doi:10.3969/j.issn.1006-1959.2021.15.044]
[6]张晓和,程 雪,周文娟,等.基于网络平台的追踪延伸护理在儿科川崎病患儿中的应用效果[J].医学信息,2023,36(23):161.[doi:10.3969/j.issn.1006-1959.2023.23.041]
　ZHANG Xiao-he,CHENG Xue,ZHOU Wen-juan,et al.Application Effect of Tracking Extended Nursing Based on Network Platform in Children with Kawasaki Disease in Pediatrics Department[J].Journal of Medical Information,2023,36(16):161.[doi:10.3969/j.issn.1006-1959.2023.23.041]
[7]姜亚男,张明瑛.丙种球蛋白治疗川崎病患儿的效果及对抗血小板聚集相关因子免疫功能的影响[J].医学信息,2022,35(11):118.[doi:10.3969/j.issn.1006-1959.2022.11.030]
　JIANG Ya-nan,ZHANG Ming-ying.Effect of Gamma Globulin on Immune Function of Antiplatelet Aggregation Related Factors in Children with Kawasaki Disease[J].Journal of Medical Information,2022,35(16):118.[doi:10.3969/j.issn.1006-1959.2022.11.030]

更新日期/Last Update: 1900-01-01