[1]周宏芳.熊去氧胆酸治疗妊娠期肝内胆汁淤积症患者的临床疗效及对母婴结局的影响[J].医学信息,2022,35(16):94-97.[doi:10.3969/j.issn.1006-1959.2022.16.022]
　ZHOU Hong-fang.Clinical Effect of Ursodeoxycholic Acid in Treatment of Patients with Intrahepatic Cholestasis of Pregnancy and its Influence on Maternal and Infant Outcomes[J].Journal of Medical Information,2022,35(16):94-97.[doi:10.3969/j.issn.1006-1959.2022.16.022]
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熊去氧胆酸治疗妊娠期肝内胆汁淤积症患者的临床疗效及对母婴结局的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年16期
页码:
94-97
栏目:
论著
出版日期:
2022-08-15

文章信息/Info

Title:
Clinical Effect of Ursodeoxycholic Acid in Treatment of Patients with Intrahepatic Cholestasis of Pregnancy and its Influence on Maternal and Infant Outcomes
文章编号:
1006-1959（2022）16-0094-04
作者:
周宏芳
（上饶市广信区人民医院妇产科，江西 上饶 334100）
Author(s):
ZHOU Hong-fang
(Department of Obstetrics and Gynecology,Shangrao Guangxin District People’s Hospital,Shangrao 334100,Jiangxi,China)
关键词:
妊娠期肝内胆汁淤积症; 熊去氧胆酸; 肝功能; 皮肤瘙痒症状; 母婴结局
Keywords:
Intrahepatic cholestasis of pregnancy; Ursodeoxycholic acid; Liver function; Skin pruritus; Maternal and infant outcome
分类号:
R714.255
DOI:
10.3969/j.issn.1006-1959.2022.16.022
文献标志码:
A
摘要:
目的 研究熊去氧胆酸治疗妊娠期肝内胆汁淤积症（ICP）患者的临床疗效及对母婴结局的影响。方法 选取2019年5月-2021年5月上饶市广信区人民医院妇产科收治的60例ICP患者，采用随机数字表法分为对照组和观察组，各30例。对照组采用常规对症治疗，观察组在对照组基础上应用熊去氧胆酸治疗，比较两组临床疗效、皮肤瘙痒症状、肝功能指标[谷丙转氨酶（ALT）、血胆汁酸（TBA）、谷草转氨酶（AST）]、血清细胞因子[白细胞介素-17（IＬ-17）和转化生长因子-β（TGF-β）]、母婴结局。结果 观察组治疗总有效率为93.33%，高于对照组的76.67%，差异有统计学意义（P＜0.05）；观察组治疗后皮肤瘙痒症状积分低于对照组，症状缓解时间短于对照组，差异有统计学意义（P＜0.05）；观察组TBA、ALT、AST水平低于对照组，差异有统计学意义（P＜0.05）；观察组IL-17水平低于对照组，TGF-β水平高于对照组，差异有统计学意义（P＜0.05）；观察组不良结局发生率为10.00%，低于对照组的30.00%，差异有统计学意义（P＜0.05）。结论 熊去氧胆酸治疗ICP的疗效肯定，可缓解瘙痒症状，改善肝功能，减少肝内胆汁酸淤积，同时调节细胞因子水平，改善母婴结局。
Abstract:
Objective To study the clinical efficacy of ursodeoxycholic acid in the treatment of patients with intrahepatic cholestasis of pregnancy (ICP) and its effect on maternal and infant outcomes.Methods From May 2019 to May 2021,60 patients with ICP admitted to the Department of Obstetrics and Gynecology of Shangrao Guangxin District People’s Hospital were selected and divided into control group and observation group by random number table method, with 30 cases in each group. The control group was treated with conventional symptomatic treatment, and the observation group was treated with ursodeoxycholic acid on the basis of the control group. The clinical efficacy, skin itching symptoms, liver function indexes [alanine aminotransferase (ALT), blood bile acid (TBA), aspartate aminotransferase (AST)], serum cytokines [interleukin-17 (IL-17) and transforming growth factor-β (TGF-β)], maternal and infant outcomes were compared between the two groups.Results The total effective rate of treatment in the observation group was 93.33%, which was higher than 76.67% in the control group, and the difference was statistically significant (P<0.05). The skin pruritus symptom score of the observation group was lower than that of the control group, and the symptom relief time was shorter than that of the control group, the differences were statistically significant (P<0.05). The levels of TBA, ALT and AST in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05). The level of IL-17 in the observation group was lower than that in the control group, and the level of TGF-β was higher than that in the control group, the differences were statistically significant (P<0.05). The incidence of adverse outcomes in the observation group was 10.00%, which was lower than 30.00% in the control group, and the differences were statistically significant (P<0.05).Conclusion Ursodeoxycholic acid is effective in the treatment of ICP, which can relieve pruritus, improve liver function, reduce intrahepatic cholestasis, regulate cytokine levels, and improve maternal and infant outcomes.

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更新日期/Last Update: 1900-01-01