[1]赵 慧,巩林霞,魏兆丽,等.脂质代谢指标在2型糖尿病肾病中的表达水平及与尿白蛋白的相关性[J].医学信息,2022,35(16):109-111.[doi:10.3969/j.issn.1006-1959.2022.16.026]
　ZHAO Hui,GONG Lin-xia,WEI Zhao-li,et al.Expression of Lipid Metabolism Indexes in Type 2 Diabetic Nephropathy and its Correlation with Urinary Albumin[J].Journal of Medical Information,2022,35(16):109-111.[doi:10.3969/j.issn.1006-1959.2022.16.026]
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脂质代谢指标在2型糖尿病肾病中的表达水平及与尿白蛋白的相关性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年16期
页码:
109-111
栏目:
论著
出版日期:
2022-08-15

文章信息/Info

Title:
Expression of Lipid Metabolism Indexes in Type 2 Diabetic Nephropathy and its Correlation with Urinary Albumin
文章编号:
1006-1959（2022）16-0109-03
作者:
赵 慧; 巩林霞; 魏兆丽; 等
（滨州市中心医院内分泌科，山东 滨州 251700）
Author(s):
ZHAO Hui; GONG Lin-xia; WEI Zhao-li; et al.
(Department of Endocrinology,Binzhou Central Hospital,Binzhou251700,Shandong, China)
关键词:
2型糖尿病; 尿白蛋白排泄率; 脂代谢紊乱; 糖尿病肾病
Keywords:
Type 2 diabetes mellitus; Urinary albumin excretion rate; Lipid metabolism disorder; Diabetic nephropathy
分类号:
R587.2；R277.5；
DOI:
10.3969/j.issn.1006-1959.2022.16.026
文献标志码:
A
摘要:
目的 探究与分析脂质代谢指标在2型糖尿病肾病中的表达水平及与尿白蛋白的相关性。方法 回顾性分析我院自2020 年1月-2021年5月收治的2型糖尿病肾病患者108例的临床资料，按照不同尿白蛋白排泄率（UAER）水平分为微量白蛋白尿组（n=39）、正常白蛋白尿组（n=32）、大量白蛋白尿组（n=37），比较三组一般资料、脂代谢相关指标，同时采用Pearson相关性对2型糖尿病患者不同UAER水平与脂代谢异常的相关性。结果 微量白蛋白尿组、大量白蛋白尿组甘油三酯、总胆固醇、低密度脂蛋白水平高于正常白蛋白尿组，高密度脂蛋白水平低于正常白蛋白尿组，差异有统计学意义（P＜0.05）；大量白蛋白尿组甘油三酯、总胆固醇、低密度脂蛋白水平高于微量白蛋白尿组，高密度脂蛋白水平低于微量白蛋白尿组，差异有统计学意义（P＜0.05）；Pearon相关性分析可见，UAER与甘油三酯、总胆固醇、低密度脂蛋白呈正相关（r=0.458、0.551、0.658，P＜0.05），与高密度脂蛋白呈负相关（r=-0.325，P＜0.05）。结论 随着UAER水平的升高，甘油三酯、总胆固醇、低密度脂蛋白也呈现出升高的趋势，但高密度脂蛋白呈现出降低的趋势。
Abstract:
Objective To explore and analyze the expression level of lipid metabolism index in type 2 diabetic nephropathy and its correlation with urinary albumin.Methods The clinical data of 108 patients with type 2 diabetic nephropathy admitted to our hospital from January 2020 to May 2021 were retrospectively analyzed. According to different urinary albumin excretion rate (UAER) levels, they were divided into microalbuminuria group (n=39), normal albuminuria group (n=32) and massive proteinuria group (n=37). The general data and lipid metabolism related indexes of the three groups were compared. At the same time, the correlation between different UAER levels and abnormal lipid metabolism in patients with type 2 diabetes mellitus was analyzed by Pearson correlation.Results The levels of triglyceride, total cholesterol and low-density lipoprotein in microalbuminuria group and massive proteinuria group were higher than those in normal proteinuria group, and the level of high-density lipoprotein was lower than that in normal proteinuria group, the difference was statistically significant (P<0.05). The levels of triglyceride, total cholesterol and low-density lipoprotein in the massive proteinuria group were higher than those in the microalbuminuria group, and the level of high-density lipoprotein was lower than that in the microalbuminuria group, the difference was statistically significant (P<0.05). Pearon correlation analysis showed that UAER was positively correlated with triglyceride, total cholesterol and low density lipoprotein (r=0.458, 0.551, 0.658, P<0.05), and negatively correlated with high density lipoprotein (r=-0.325, P<0.05).Conclusion With the increase of UAER level, triglyceride, total cholesterol and low density lipoprotein also show an increasing trend, but high density lipoprotein shows a decreasing trend.

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更新日期/Last Update: 1900-01-01