[1]吴六仔.纳络酮联合局部亚低温治疗高血压脑出血的疗效及对患者神经功能恢复、认知改善的影响[J].医学信息,2022,35(16):125-127.[doi:10.3969/j.issn.1006-1959.2022.16.031]
　WU Liu-zi.Effect of Naloxone Combined with Local Mild Hypothermia on Hypertensive Cerebral Hemorrhage and its Effect on Neurological Function Recovery and Cognitive Improvement[J].Journal of Medical Information,2022,35(16):125-127.[doi:10.3969/j.issn.1006-1959.2022.16.031]
点击复制

纳络酮联合局部亚低温治疗高血压脑出血的疗效及对患者神经功能恢复、认知改善的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年16期
页码:
125-127
栏目:
临床研究
出版日期:
2022-08-15

文章信息/Info

Title:
Effect of Naloxone Combined with Local Mild Hypothermia on Hypertensive Cerebral Hemorrhage and its Effect on Neurological Function Recovery and Cognitive Improvement
文章编号:
1006-1959（2022）16-0125-03
作者:
吴六仔
（上栗县人民医院脑外ICU科，江西 上栗 337009）
Author(s):
WU Liu-zi
(Department of Extracerebral ICU,Shangli County People’s Hospital,Shangli 337009,Jiangxi,China)
关键词:
纳络酮; 局部亚低温; 高血压脑出血; 神经功能
Keywords:
Naloxone; Local mild hypothermia; Hypertensive cerebral hemorrhage; Neurological function
分类号:
R743
DOI:
10.3969/j.issn.1006-1959.2022.16.031
文献标志码:
A
摘要:
目的 观察纳络酮联合局部亚低温治疗高血压脑出血的疗效及对患者神经功能恢复、认知改善的影响。方法 选取2020年6月-2021年6月我院治疗的84例高血压脑出血患者为研究对象，采用随机数字表法分为对照组和观察组，各42例。对照组给予纳络酮，观察组在对照组基础上给予局部亚低温治疗，比较两组脑水肿体积、神经功能恢复、认知改善情况、日常生活能力恢复情况及并发症发生情况。结果 两组治疗后3 d、1周脑水肿体积均小于治疗前，且观察组小于对照组（P＜0.05）；两组治疗后NIHSS评分低于治疗前，MMSE评分高于治疗前，但观察组NIHSS评分低于对照组，MMSE评分高于对照组（P＜0.05）；观察组ADL优良率为88.10%，高于对照组的78.57%（P＜0.05）；两组并发症发生率比较，差异无统计学意义（P＞0.05）。结论 纳络酮联合局部亚低温治疗高血压脑出血的疗效良好，可提高患者日常生活能力，降低神经功能缺损，减小脑水肿体积，提高患者认知功能，且不增加并发症发生几率，是一种安全、有效的治疗方法。
Abstract:
Objective To observe the therapeutic effect of naloxone combined with local mild hypothermia on hypertensive cerebral hemorrhage and its influence on the recovery of neurological function and cognitive improvement.Methods A total of 84 patients with hypertensive cerebral hemorrhage treated in our hospital from June 2020 to June 2021 were selected as the study subjects. They were divided into control group and observation group according to the random number table method, with 42 cases in each group. The control group was given naloxone, and the observation group was given local mild hypothermia treatment on the basis of the control group. The brain edema volume, neurological function recovery, cognitive improvement, daily living ability recovery and complications were compared between the two groups.Results The volume of cerebral edema at 3 days and 1 week after treatment in the two groups was smaller than that before treatment, and the observation group was smaller than the control group (P<0.05). After treatment, the NIHSS score of the two groups was lower than that before treatment, and the MMSE score was higher than that before treatment, but the NIHSS score of the observation group was lower than that of the control group, and the MMSE score was higher than that of the control group (P<0.05). The excellent and good rate of ADL in the observation group was 88.10%, which was higher than 78.57% in the control group (P<0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05).Conclusion Naloxone combined with local mild hypothermia is effective in the treatment of hypertensive cerebral hemorrhage, which can improve the daily living ability, reduce the neurological deficit and the volume of cerebral edema, improve the cognitive function, and do not increase the incidence of complications. It is a safe and effective treatment method.

参考文献/References:

[1]陆弘盈,覃重桥,余松祚,等.亚低温治疗对重型颅脑损伤患者血浆内皮素的影响[J].微创医学,2016,11(4):509-512.[2]余国亮.尼莫地平对高血压脑出血急性期患者神经功能缺损程度评分、脑血流动力学参数及临床疗效的影响[J].中国基层医药,2017,24(9):1302-1307.[3]Kowalski RG,Haarbauer-Krupa JK,Bell JM,et al.Acute Ischemic Stroke After Moderate to Severe Traumatic Brain Injury: Incidence and Impact on Outcome[J].Stroke,2017,48(7):1802-1809.[4]王承辉,阮海林,何嗣华,等.出诊现场联合应用小剂量甘露醇与纳络酮对高血压性急性脑出血重症患者血压及GCS评分的影响[J].实用医学杂志,2011,27(12):2246-2248.[5]王峻,周滨音,吴星,等.纳络酮血肿腔内注射治疗高血压脑出血的临床观察[J].中国临床神经外科杂志,2007,12(1):25-27.[6]汪俊.亚低温疗法对脑出血患者血清炎性因子水平及预后的影响[J].神经损伤与功能重建,2018,13(6):316-317.[7]黄艳丽,张海垠.局部亚低温治疗对高血压性脑出血患者血清hs-CRP及Hcy水平的影响研究[J].中国实验诊断学,2020,24(1):11-14.[8]傅佳峰,杨国芳,张春亭,等.高血压脑出血不同术式疗效比较[J].浙江创伤外科,2021,26(2):371-373.[9]Yang G,Shao G.Clinical effect of minimally invasive intracranial hematoma in treating hypertensive cerebral hemorrhage[J].Pak J Med Sci,2016,32(3):677-681.[10]王琨,王伟宁,宋波,等.微创颅内血肿抽吸术对高血压脑出血患者BNP、CRP、Hcy水平和生活质量的影响[J].河北医药,2018,40(4):526．[11]王宏宇.亚低温治疗老年重型颅脑创伤患者的临床疗效[J].中华行为医学与脑科学杂志,2016,25(4):350-353[12]陈建时,郭蕾,潘利伟,等.长时程亚低温疗法对急性重型颅脑损伤患者免疫功能的影响[J].中华神经外科杂志,2016,32(6):574-578[13]漆建,苟章洋,唐晓平,等.亚低温治疗对重型颅脑损伤患者免疫功能及预后的影响[J].中华神经外科疾病研究杂志,2016,15(6):538-540.[14]杨生琴.超早期小骨窗微创脑出血清除术后血清VEGF、Ang-1、HPA 水平变化及意义[J].陕西医学杂志,2019,48(1):48-51．[15]Cao Y,Tian M,Fang Q,et al.Joint Effects of GWAS SNPs in Coagulation System Confer Risk to Hypertensive Intracerebral Hemorrhage[J].Neuromolecular Med,2017,19(2-3):395-405.[16]熊学辉,瞿丹霞.亚低温治疗在急性重型颅脑损伤中的应用[J].新乡医学院学报,2016,33(11):973-975.[17]淡冰.小骨窗手术和局部亚低温联合治疗高血压脑出血76例分析[J].重庆医学,2008,37(16):1828-1829.[18]Qureshi AI,Qureshi MH.Acute hypertensive response in patients with intracerebral hemorrhage pathophysiology and treatment[J].J Cereb Blood Flow Metab,2018,38(9):1551-1563.[19]黄艳丽,张海垠.高血压脑出血患者应用依达拉奉联合局部亚低温治疗对患者神经损伤和认知功能的影响[J].实用医院临床杂志,2020,17(1):88-91.[20]朱海,龙平,赖日华.纳络酮治疗急性重型颅脑损伤的疗效及其对患者血浆内皮素含量的影响[J].海南医学,2019,30(1):73-75.

更新日期/Last Update: 1900-01-01