[1]张丹丹,王义围,谢云博,等.H型高血压患者晨峰现象与早期肾损伤因子NGAL的关系[J].医学信息,2022,35(17):45-48.[doi:10.3969/j.issn.1006-1959.2022.17.010]
　ZHANG Dan-dan,WANG Yi-wei,XIE Yun-bo,et al.The Relationship Between Morning Surge and Early Renal Injury Factor NGAL in Patients with H-type Hypertension[J].Journal of Medical Information,2022,35(17):45-48.[doi:10.3969/j.issn.1006-1959.2022.17.010]
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H型高血压患者晨峰现象与早期肾损伤因子NGAL的关系()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年17期
页码:
45-48
栏目:
论著
出版日期:
2022-09-01

文章信息/Info

Title:
The Relationship Between Morning Surge and Early Renal Injury Factor NGAL in Patients with H-type Hypertension
文章编号:
1006-1959（2022）17-0045-04
作者:
张丹丹; 王义围; 谢云博; 等
（承德医学院附属医院全科医疗科1，神经内科2，河北 承德 067000）
Author(s):
ZHANG Dan-dan; WANG Yi-wei; XIE Yun-bo; et al.
(Department of General Medicine1,Department of Neurology2,Affiliated Hospital of Chengde Medical University,Chengde 067000,Hebei,China)
关键词:
H型高血压; 晨峰现象; 早期肾损伤; NGAL
Keywords:
H-type hypertension; Morning peak phenomenon; Early renal injury; NGAL
分类号:
R544.1；R692
DOI:
10.3969/j.issn.1006-1959.2022.17.010
文献标志码:
A
摘要:
目的 探讨H型高血压患者晨峰现象与早期肾损伤因子NGAL的关系。方法 选取承德医学院附属医院全科医疗科住院的224例H型高血压（Hcy≥10 μmol/L）患者行24h动态血压监测（ABPM），按睡-谷晨峰值计算方法分组，＞28 mmHg为晨峰组（n=109），≤28 mmHg为非晨峰组（n=115），比较两组空腹血糖（FBG）、同型半胱氨酸（Hcy）、血脂、肌酐（Cr）、尿酸（UA）、尿素氮（BUN）、胱抑素C（CysC）、β2微球蛋白（β2-MG）、中性粒细胞明胶酶相关脂质运载蛋白（NGAL）。结果 晨峰组24h平均收缩压、白昼平均收缩压、夜间平均收缩压、收缩压晨峰、NGAL、CysC、β2-MG高于非晨峰组（P＜0.05）；两组24h平均舒张压、白昼平均舒张压、夜间平均舒张压、舒张压晨峰、Cr、 BUN、UA比较，差异无统计学意义（P＞0.05）；Pearson相关分析显示NGAL与CysC、收缩压晨峰、β2-MG、呈中、高度相关（r=0.581、0.516、0.759，P＜0.05）；与24h平均收缩压、FBG、Cr、呈低度相关（r=0.294、0.254、0.153，P＜0.05），与BUN无相关（r=0.000，P＞0.05）。结论 H型高血压患者收缩压晨峰是引起肾损伤的重要因素，NGAL是反映H型高血压早期肾损伤的重要指标。
Abstract:
Objective To investigate the relationship between morning surge and NGAL in patients with H-type hypertension.Methods A total of 224 patients with H-type hypertension (Hcy≥10 μmol/L) who were hospitalized in the Department of General Medicine, Affiliated Hospital of Chengde Medical University were selected for 24-hour ambulatory blood pressure monitoring (ABPM). According to the calculation method of sleep-valley morning peak, >28 mmHg was the morning peak group (n=109), and ≤28 mmHg was the non-morning peak group (n=115). Fasting blood glucose (FBG), homocysteine (Hcy), blood lipids, creatinine (Cr), uric acid (UA), urea nitrogen (BUN), cystatin C (CysC), β2 microglobulin (β2-MG), neutrophil gelatinase-associated lipocalin (NGAL) were compared between the two groups.Results The 24-hour mean systolic blood pressure, daytime mean systolic blood pressure, nighttime mean systolic blood pressure, morning systolic blood pressure surge, NGAL, CysC and β2-MG in the morning peak group were higher than those in the non-morning peak group (P<0.05). There was no significant difference in 24h mean diastolic blood pressure, daytime mean diastolic blood pressure, nighttime mean diastolic blood pressure, morning peak of diastolic blood pressure, Cr, BUN and UA between the two groups (P>0.05). Pearson correlation analysis showed that NGAL was moderately and highly correlated with CysC, morning blood pressure surge and β2-MG (r=0.581, 0.516, 0.759, P<0.05), there was a low correlation with 24h mean systolic blood pressure, FBG, Cr (r=0.294,0.254,0.153, P<0.05), but no correlation with BUN (r=0.000, P>0.05).Conclusion Morning blood pressure surge is an important factor causing renal injury in patients with H-type hypertension, and NGAL is an important indicator of early renal injury in H-type hypertension.

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更新日期/Last Update: 1900-01-01