[1]张翻翻,李波妮,王 瑶.湿疹Ⅱ号洗剂熏洗治疗慢性肛周湿疹临床疗效及其对外周血IFN-γ、IL-4表达的影响[J].医学信息,2022,35(18):131-134.[doi:10.3969/j.issn.1006-1959.2022.18.036]
　ZHANG Fan-fan,LI Bo-ni,WANG Yao.Effect of Eczema Ⅱ Lotion Fumigation on Chronic Perianal Eczema and its Influence on the Expression of IFN-γ and IL-4 in Peripheral Blood[J].Journal of Medical Information,2022,35(18):131-134.[doi:10.3969/j.issn.1006-1959.2022.18.036]
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湿疹Ⅱ号洗剂熏洗治疗慢性肛周湿疹临床疗效及其对外周血IFN-γ、IL-4表达的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年18期
页码:
131-134
栏目:
中医中药
出版日期:
2022-09-15

文章信息/Info

Title:
Effect of Eczema Ⅱ Lotion Fumigation on Chronic Perianal Eczema and its Influence on the Expression of IFN-γ and IL-4 in Peripheral Blood
文章编号:
1006-1959（2022）18-0131-04
作者:
张翻翻; 李波妮; 王 瑶
（榆林市中医医院肛肠科，陕西 榆林 719000）
Author(s):
ZHANG Fan-fan; LI Bo-ni; WANG Yao
(Department of Proctology,Yulin Hospital of Traditional Chinese Medicine,Yulin 719000,Shaanxi,China)
关键词:
湿疹Ⅱ号洗剂; 慢性肛周湿疹;  IFN-γ; IL-4
Keywords:
Eczema Ⅱ lotion fumigation; Chronic perianal eczema; IFN-γ; IL-4
分类号:
R275.9
DOI:
10.3969/j.issn.1006-1959.2022.18.036
文献标志码:
A
摘要:
目的 观察湿疹Ⅱ号洗剂熏洗治疗慢性肛周湿疹的临床疗效，及其对外周血IFN-γ、IL-4表达的影响，为湿疹Ⅱ号洗剂治疗慢性肛周湿疹提供临床应用依据。方法 选取2020年1月-12月于榆林市中医医院肛肠科诊治的92例慢性肛周湿疹患者，采用随机数字表法分为观察组和对照组，各46例。对照组使用皮肤康洗液熏洗，观察组使用湿疹Ⅱ号洗剂熏洗。比较两组患者治疗前后肛周皮肤潮湿、瘙痒、皮损面积、皮损形态及外周血IFN-γ、IL-4水平，评价其临床总疗效。结果 观察组治疗后在肛周皮肤潮湿、皮肤瘙痒缓解、皮损面积减小、皮损形态改善方面单独评分均优于对照组，差异有统计学意义（P＜0.05）；观察组总有效率为97.78%，高于对照组的71.11%，差异有统计学意义（P＜0.05）；两组治疗后IFN-γ水平均较治疗前升高，IL-4水平较治疗前降低，组间比较，差异有统计学意义（P＜0.05）。结论 湿疹Ⅱ号洗剂熏洗治疗慢性肛周湿疹可以有效改善患者肛门局部微循环，促进炎症消退吸收，有利于缓解和改善局部瘙痒、潮湿、皮损及苔藓化症状。
Abstract:
Objective To observe and analyze the clinical effect of eczema Ⅱ lotion fumigation on chronic perianal eczema and its effect on the expression of IFN-γ and IL-4 in peripheral blood, so as to provide the clinical application basis for eczema Ⅱ lotion fumigation in treating chronic perianal eczema.Methods A total of 92 patients with chronic perianal eczema diagnosed and treated in the anorectal department of Yulin Hospital of Traditional Chinese Medicine from January to December 2020 were collected and divided into observation group and control group by random number table method, with 46 cases in each group. The control group was treated with skin lotion fumigation, the observation group used eczema Ⅱ lotion fumigation. The perianal skin dampness, itching, skin lesion area, skin lesion morphology and peripheral blood IFN-γ and IL-4 levels were compared between the two groups before and after treatment, and the total clinical efficacy was evaluated.Results After treatment, the scores of perianal skin dampness, skin itching relief, skin lesion area reduction and skin lesion morphology improvement in the observation group were better than those in the control group (P<0.05). The total effective rate of the observation group was 97.78%, which was higher than 71.11% of the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of IFN-γ in the two groups were higher than those before treatment, and the levels of IL-4 were lower than those before treatment. The difference between the two groups was statistically significant (P<0.05).Conclusion Eczema Ⅱ Lotion fumigation treatment of chronic perianal eczema can significantly improve the patient’s anal local microcirculation, promote inflammation subsided absorption, help alleviate and improve local itching, dampness, skin lesions and lichenized symptoms.

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更新日期/Last Update: 1900-01-01