[1]晏香花,熊 芳.氟康唑联合克霉唑阴道栓对复发性念珠菌阴道炎患者短期复发率及氧化应激产物的影响[J].医学信息,2022,35(21):84-87.[doi:10.3969/j.issn.1006-1959.2022.21.019]
 YAN Xiang-hua,XIONG Fang.Effect of Fluconazole Combined with Clotrimazole Vaginal Suppository on Short-term Recurrence Rate and Oxidative Stress Products in Patients with Recurrent Candidal Vaginitis[J].Journal of Medical Information,2022,35(21):84-87.[doi:10.3969/j.issn.1006-1959.2022.21.019]
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氟康唑联合克霉唑阴道栓对复发性念珠菌阴道炎患者短期复发率及氧化应激产物的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年21期
页码:
84-87
栏目:
论著
出版日期:
2022-11-01

文章信息/Info

Title:
Effect of Fluconazole Combined with Clotrimazole Vaginal Suppository on Short-term Recurrence Rate and Oxidative Stress Products in Patients with Recurrent Candidal Vaginitis
文章编号:
1006-1959(2022)21-0084-04
作者:
晏香花熊 芳
(上高县中医院妇产科,江西 上高 336400)
Author(s):
YAN Xiang-huaXIONG Fang
(Department of Obstetrics and Gynecology,Shanggao County Hospital of Traditional Chinese Medicine,Shanggao 336400,Jiangxi,China)
关键词:
念珠菌阴道炎氟康唑克霉唑阴道栓氧化应激产物炎症因子
Keywords:
andida vaginitisFluconazoleClotrimazole vaginal suppositoryOxidative stress productsInflammatory factors
分类号:
R711.31
DOI:
10.3969/j.issn.1006-1959.2022.21.019
文献标志码:
A
摘要:
目的 探讨复发性念珠菌阴道炎患者联合应用氟康唑与克霉唑阴道栓治疗的效果,并分析其对患者短期复发率及氧化应激产物的影响。方法 选择2019年1月-2021年1月于上高县中医院妇产科就诊的60例复发性念珠菌阴道炎患者为研究对象,根据随机数字表法分为试验组和对照组,每组30例。对照组给予克霉唑阴道栓治疗,试验组在对照组基础上联合氟康唑治疗。比较两组氧化应激产物水平[丙二醛(MDA)、超氧化物歧化酶(SOD)]、炎症因子水平[白介素-6(IL-6)、C反应蛋白(CRP)、白介素-10(IL-10)]、性激素水平[黄体生成素(LH)、雌二醇(E2)]、临床疗效及短期复发率。结果 治疗14 d后,试验组MDA、CRP、IL-10、IL-6、LH水平低于对照组,差异有统计学意义(P<0.05);试验组SOD、E2水平高于对照组,差异有统计学意义(P<0.05);试验组治疗总有效率为93.33%,高于对照组的66.67%,差异有统计学意义(P<0.05);两组随访1、3个月复发率比较,差异无统计学意义(P>0.05);随访6个月,试验组疾病复发率低于对照组,差异有统计学意义(P<0.05)。结论 联合应用氟康唑与克霉唑阴道栓治疗复发性念珠菌阴道炎患者的疗效确切,可降低机体氧化应激及阴道炎症反应,调节性激素水平,还可降低短期复发率。
Abstract:
Objective To investigate the effect of fluconazole combined with clotrimazole vaginal suppository in patients with recurrent candidal vaginitis, and to analyze its effect on short-term recurrence rate and oxidative stress products.Methods From January 2019 to January 2021, 60 patients with recurrent candida vaginitis who were treated in the Department of Obstetrics and Gynecology of Shanggao County Hospital of Traditional Chinese Medicine were selected as the research objects. According to the random number table method, they were divided into experimental group and control group, with 30 cases in each group. The control group was treated with clotrimazole vaginal suppository, and the experimental group was treated with fluconazole on the basis of the control group. The levels of oxidative stress products [malondialdehyde (MDA), superoxide dismutase (SOD)], inflammatory factors [interleukin-6 (IL-6), C-reactive protein (CRP), interleukin-10 (IL-10)], sex hormone levels [luteinizing hormone (LH), estradiol (E2)], clinical efficacy and short-term recurrence rate were compared between the two groups.Results After 14 days of treatment, the levels of MDA, CRP, IL-10, IL-6 and LH in the experimental group were lower than those in the control group, and the differences were statistically significant (P<0.05). The levels of SOD and E2 in the experimental group were higher than those in the control group (P<0.05). The total effective rate of treatment in the experimental group was 93.33%, which was higher than 66.67% in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the recurrence rate between the two groups at 1 and 3 months of follow-up (P>0.05). After 6 months of follow-up, the recurrence rate of the experimental group was lower than that of the control group, and the difference was statistically significant (P<0.05).Conclusion The combination of fluconazole and clotrimazole vaginal suppository is effective in the treatment of patients with recurrent candidal vaginitis, which can reduce oxidative stress and vaginal inflammation, regulate sex hormone levels, and reduce short-term recurrence rate.

参考文献/References:

[1]秦春雨,封学伟,冯欣.基于AGREE Ⅱ的细菌性阴道炎治疗临床实践指南评价[J].中国药学杂志,2021,56(7):601-606.[2]沈慧,顾以璐,左绪磊.氟康唑单独及联合克霉唑栓治疗老年念球菌性阴道炎的疗效及对生活质量的影响[J].中国老年学杂志,2016,36(3):691-693.[3]Papon N,Naglik JR.Candida vaginitis:the importance of mitochondria and type Ⅰ interferon signalling[J].Mucosal Immunol,2021,14(5):975-977. [4]周艳鹏,刘红艳,姬静.克霉唑阴道栓联合氟康唑治疗霉菌性阴道炎的疗效观察[J].现代药物与临床,2021,36(2):350-354.[5]张小京.氟康唑联合克霉唑阴道片治疗念珠菌阴道炎的临床疗效[J].临床合理用药杂志,2018,11(18):20-21.[6]崔健.联合应用臭氧妇科治疗仪氟康唑克霉唑阴道泡腾片治疗复发性霉菌性阴道炎临床疗效[J].山西医药杂志,2021,50(13):2045-2047.[7]李婷,刘朝晖.2020年美国妇产科医师学会《非妊娠期阴道炎》管理指南解读[J].中国实用妇科与产科杂志,2021,37(2):205-207. [8]王辰,王慧慧,李焕荣,等.《2018欧洲国际性病控制联盟/世界卫生组织关于阴道分泌物(阴道炎症)管理指南》解读[J].中国实用妇科与产科杂志,2018,34(12):1360-1365.[9]刘聃.氟康唑联合克霉唑阴道片对复发性念珠菌性阴道炎患者白细胞介素-2白细胞介素-8水平及预后的影响[J].中国药物与临床,2020,20(23):3945-3947.[10]Su J,Ma J,Mo F,et al.Thermosensitive hydrogels as a controlled release system for alkannin to improve localized treatment of Candida vaginitis after external beam radiotherapy in vitro and in vivo[J].Pathog Dis,2019,77(4):ftz041.[11]李艳梅,贺雯,欧洁贤,等.乳酸菌阴道胶囊联合氟康唑治疗念珠菌性阴道炎的疗效及对阴道菌群的影响[J].海南医学,2019,30(19):2521-2524.[12]朱焕金,汤凤珍.念珠菌性阴道炎复发时采用氟康唑联合克霉唑治疗的临床意义探讨[J].中外医学研究,2019,17(20):139-141.[13]赵涵,张雪艳,冯欣.氟康唑治疗念珠菌性外阴阴道炎的疗效和不良反应分析[J].临床药物治疗杂志,2018,16(11):61-64.[14]张展,白会会,王风娟,等.复发性外阴阴道假丝酵母菌病患者反复发作期阴道分离菌株的同源性及耐药性分析[J].中华妇产科杂志,2020,55(3):177-182. [15]姜联明.苦参凝胶结合氟康唑胶囊治疗复发性霉菌性阴道炎临床效果观察[J].山西医药杂志,2018,47(21):2563-2565. [16]Sobel JD,Sobel R.Current treatment options for vulvovaginal candidiasis caused by azole-resistant Candida species[J].Expert Opin Pharmacother,2018,19(9):971-977.[17]彭敏,罗琼,张玲.克霉唑阴道片联合乳酸杆菌阴道胶囊对妊娠合并念珠菌性阴道炎患者的疗效[J].中国医师杂志,2020,22(6):871-874.[18]李莉,刘潇祎,苏刘艳,等.屏边三七提取物协同氟康唑抗耐药白念珠菌的作用及机制研究[J].中华中医药学刊,2021,39(1):51-57,269-273.[19]郝小康,王宇鹤,徐世林,等.土槿乙酸与氟康唑联合抗白念珠菌作用的研究[J].中国真菌学杂志,2021,16(4):262-265.[20]张建敏.克霉唑栓局部应用与氟康唑口服治疗复发性念珠菌性阴道炎的疗效观察[J].中国妇幼保健,2017,32(20):4961-4963.[21]杨卓青,朱健英,赵青玲.氟康唑联合硝呋太尔治疗外阴阴道假丝酵母菌病合并需氧菌性阴道炎的临床效果[J].中国妇幼保健,2021,36(9):2045-2047. [22]张婧芳,周月娇,王凯丽.中药熏洗联合克霉唑乳膏治疗念珠菌性阴道炎疗效观察[J].检验医学与临床,2021,18(5):671-673.[23]辛丽娇,邓成敏,贾丹,等.育龄期职业女性外阴阴道念珠菌病致病因素及IFN-γ、TNF-α、IL-2对其预后的预测价值[J].中国医师杂志,2020,22(4):564-568.[24]郑伊芳.干扰素联合氟康唑对复发性外阴阴道假丝酵母菌病患者血清炎症因子水平的影响及疗效分析[J].中国药物与临床,2021,21(10):1701-1703.[25]钟钰,何维华.氟康唑联合克霉唑阴道栓治疗霉菌性阴道炎的效果观察[J].基层医学论坛,2020,24(2):196-197.[26]马卫.氟康唑胶囊辅助洁尔阴洗剂、硝酸咪康唑栓治疗念珠菌阴道炎患者的疗效分析[J].医药论坛杂志,2020,41(8):151-154.

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更新日期/Last Update: 1900-01-01