[1]朱 颖,李国栋,王 伟,等.泮托拉唑与奥美拉唑治疗Hp阳性十二指肠溃疡有效性及安全性的Meta分析[J].医学信息,2023,36(02):74-79.[doi:10.3969/j.issn.1006-1959.2023.02.015]
 ZHU Ying,LI Guo-dong,WANG Wei,et al.Meta-analysis of the Efficacy and Safety of Pantoprazole and Omeprazole in the Treatment of Hp-positive Duodenal Ulcer[J].Journal of Medical Information,2023,36(02):74-79.[doi:10.3969/j.issn.1006-1959.2023.02.015]
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泮托拉唑与奥美拉唑治疗Hp阳性十二指肠溃疡有效性及安全性的Meta分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年02期
页码:
74-79
栏目:
论著
出版日期:
2023-01-15

文章信息/Info

Title:
Meta-analysis of the Efficacy and Safety of Pantoprazole and Omeprazole in the Treatment of Hp-positive Duodenal Ulcer
文章编号:
1006-1959(2023)02-0074-06
作者:
朱 颖李国栋王 伟
(徐州市中心医院药剂科,江苏 徐州 221009)
Author(s):
ZHU YingLI Guo-dongWANG Weiet al.
(Department of Pharmacy,Xuzhou Central Hospital,Xuzhou 221009,Jiangsu,China)
关键词:
泮托拉唑奥美拉唑十二指肠溃疡幽门螺杆菌
Keywords:
PantoprazoleOmeprazoleDuodenal ulcerHelicobacter pylori
分类号:
R573.1
DOI:
10.3969/j.issn.1006-1959.2023.02.015
文献标志码:
A
摘要:
目的 通过对泮托拉唑与奥美拉唑治疗幽门螺杆菌(Hp)阳性十二指肠溃疡(DU)系统分析,针对其有效性及安全性进行评价。方法 计算机检索PubMed、外文医学信息资源检索平台(FMRS)、中国期刊全文数据库(CNKI)、万方数据库、中文科技期刊全文数据库(VIP)、中国生物医学文献数据库(CBM)等数据库,收集所有关于泮托拉唑与奥美拉唑用于治疗Hp阳性DU的随机对照试验文献,参照纳入、排除标准进行文献筛选,检索时限均为建库至2021年。由2名研究院独立筛选文献、提取资料对纳入文献进行评估,采用RevMan 5.2软件进行Meta分析。结果 纳入5项RCTs,共计517例患者。Meta分析显示,试验组与对照组Hp阳性DU溃疡愈合率(OR=0.83,95%CI:0.44~1.56,P=0.56)、Hp根除率(OR=0.63,95%CI:0.35~1.13,P=0.12)、序贯疗法溃疡愈合率(OR=1.06,95%CI:0.44~2.54,P=0.89)、序贯疗法Hp根除率(OR=0.88,95%CI:0.38~2.04,P=0.76)、不良反应发生率(OR=1.02,95%CI:0.36~2.89,P=0.96)比较,差异无统计学意义(P>0.05)。结论 泮托拉唑与奥美拉唑治疗Hp阳性DU的疗效基本相当,但因本研究中纳入的样本量较少,缺少患者病情具体情况,且所纳入的文献质量一般,因此要获得更具代表性且更加严谨的研究结果仍后续研究作进一步验证。
Abstract:
Objective To evaluate the efficacy and safety of pantoprazole and omeprazole in the treatment of Helicobacter pylori(Hp) positive duodenal ulcer (DU) by systematic analysis.Methods Databases such as PubMed, Foreign Medical Information Resource Search Platform ( FMRS ), China Journal Full-text Database (CNKI), Wanfang Database, Chinese Science and Technology Journal Full-text Database (VIP), and China Biomedical Literature Database (CBM) were searched by computer to collect all randomized controlled trials of pantoprazole and omeprazole for the treatment of Hp-positive DU. The literature was screened according to the inclusion and exclusion criteria. The search time limit was from the establishment of the database to 2021. Two reviewers independently screened literature and extracted data to evaluate the included studies. Meta-analysis was performed using RevMan 5.2 software.Results Five RCTs involving 517 patients were included. Meta-analysis showed. Hp-positive DU ulcer healing rate (OR=0.83,95%CI:0.44-1.56,P=0.56), Hp eradication rate (OR=0.63,95%CI:0.35-1.13,P=0.12), sequential therapy ulcer healing rate (OR=1.06,95%CI:0.44-2.54,P=0.89), sequential therapy Hp eradication rate (OR=0.88,95%CI:0.38-2.04,P=0.76), and incidence of adverse reactions (OR=1.02,95%CI:0.36-2.89,P=0.96) were compared between the experimental group and the control group, the difference was not statistically significant (P>0.05).Conclusion The efficacy of pantoprazole and omeprazole in the treatment of Hp-positive DU is basically the same. However, due to the small sample size included in this study, the lack of specific conditions of the patient’s condition, and the quality of the included literature, more representative and rigorous research results are still needed for further verification.

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更新日期/Last Update: 1900-01-01