[1]潘盛强,李 宁.TLRs信号通路介导下相关因子对骨关节炎的干预机制[J].医学信息,2023,36(02):167-170.[doi:10.3969/j.issn.1006-1959.2023.02.037]
 PAN Sheng-qiang,LI Ning.Intervention Progress of Related Factors in Osteoarthritis Mediated by TLRs Signal Pathway[J].Journal of Medical Information,2023,36(02):167-170.[doi:10.3969/j.issn.1006-1959.2023.02.037]
点击复制

TLRs信号通路介导下相关因子对骨关节炎的干预机制()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年02期
页码:
167-170
栏目:
综述
出版日期:
2023-01-15

文章信息/Info

Title:
Intervention Progress of Related Factors in Osteoarthritis Mediated by TLRs Signal Pathway
文章编号:
1006-1959(2023)02-0167-04
作者:
潘盛强李 宁
(甘肃中医药大学中医临床学院,甘肃 兰州 730000)
Author(s):
PAN Sheng-qiangLI Ning
(Clinical College of Traditional Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu,China)
关键词:
TLRs信号通路Toll样受体促炎细胞因子骨关节炎
Keywords:
LRs signal pathwayToll-like receptorsProinflammatory cytokinesOsteoarthritis
分类号:
R681
DOI:
10.3969/j.issn.1006-1959.2023.02.037
文献标志码:
A
摘要:
骨关节炎(OA)是世界范围内疼痛、残疾和社会经济成本的主要来源,目前以抑制炎症反应为靶向治疗OA已然成为了新的研究热点。Toll样受体(TLRs)信号通路可激活产生相关促炎细胞因子或趋化因子,在OA治疗中具有一定调控作用。本文现对TLRs信号通路介导下相关因子对OA的作用进行综述,旨在为OA的治疗提供一定的参考和依据。
Abstract:
Osteoarthritis (OA) is the main source of pain, disability and socio-economic costs worldwide. At present, the targeted treatment of OA by inhibiting inflammatory response has become a new research hotspot. Toll-like receptor (TLRs) signaling pathway can activate the production of related pro-inflammatory cytokines or chemokines, which has a certain regulatory role in the treatment of OA. This article reviews the effects of related factors on OA mediated by TLRs signaling pathway, aiming to provide some reference and basis for the treatment of OA.

参考文献/References:

[1]Turkiewicz A,Timpka S,Thorlund JB,et al.Knee extensor strength and body weight in adolescent men and the risk of knee osteoarthritis by middle age[J].Ann Rheum Dis,2017,76(10):1657-1661.[2]Liu-Bryan R.Synovium and the innate inflammatory network in osteoarthritis progression[J].Curr Rheumatol Rep,2013,15(5):323.[3]Shen J,Abu-Amer Y,O’Keefe RJ,et al.Inflammation and epigenetic regulation in osteoarthritis[J].Connect Tissue Res,2017,58(1):49-63.[4]Griffin TM,Scanzello CR.Innate inflammation and synovial macrophages in osteoarthritis pathophysiology[J].Clin Exp Rheumatol,2019,120(5):57-63.[5]Varela-Eirin M,Loureiro J,Fonseca E,et al.Cartilage regeneration and ageing: Targeting cellular plasticity in osteoarthritis[J].Ageing Res Rev,2018,42:56-71.[6]杨黎黎,王庆甫.通络止痛方对人膝骨关节炎滑膜炎性细胞TLR的影响[J].天津中医药大学学报,2020,39(6):656-660.[7]卢国良,邹泽良,潘耀成.TLRs/MyD88信号通路在膝骨性关节炎患者滑膜炎症中的作用[J].新疆医科大学学报,2020,43(2):196-200. [8]Korotkyi O,Dvorshchenko K,Falalyeyeva T,et al.Combined effects of probiotic and chondroprotector during osteoarthritis in rats[J].Panminerva Med,2020,62(2):93-101.[9]Liu YX,Wang GD,Wang X,et al.Effects of TLR-2/NF-κB signaling pathway on the occurrence of degenerative knee osteoarthritis: an in vivo and in vitro study[J].Oncotarget,2017,8(24):38602-38617.[10]Zhang Z,Ohto U,Shimizu T.Toward a structural understanding of nucleic acid-sensing Toll-like receptors in the innate immune system[J].FEBS Lett,2017,591(20):3167-3181.[11]Elshabrawy HA,Essani AE,Szekanecz Z,et al.TLRs,future potential therapeutic targets for RA[J].Autoimmun Rev,2017,16(2):103-113.[12]Vijay K.Toll-like receptors in immunity and inflammatory diseases: Past, present, and future[J].Int Immunopharmacol,2018,59:391-412.[13]Mukherjee S,Huda S,Sinha Babu SP.Toll-like receptor polymorphism in host immune response to infectious diseases: A review[J].Scand J Immunol,2019,90(1):e12771.[14]Joosten LA,Abdollahi-Roodsaz S,Dinarello CA,et al.Toll-like receptors and chronic inflammation in rheumatic diseases: new developments[J].Nat Rev Rheumatol,2016,12(6):344-357.[15]Chou CH,Jain V,Gibson J,et al.Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis[J].Sci Rep,2020,10(1):10868.[16]Wang Y,Wang Q,Li Y,et al.Mmm-derived lipid-associated membrane proteins activate IL-1β production through the NF-κB pathway via TLR2, MyD88,and IRAK4[J].Scientific Reports,2017,7(1):4349-4351.[17]Berthelot JM,Sellam J,Maugars Y,et al.Cartilage-gut-microbiome axis: a new paradigm for novel therapeutic opportunities in osteoarthritis[J].RMD Open,2019,5(2):e001037.[18]Panaro MA,Corrado A,Benameur T,et al.The Emerging Role of Curcumin in the Modulation of TLR-4 Signaling Pathway: Focus on Neuroprotective and Anti-Rheumatic Properties[J].Int J Mol Sci,2020,21(7):2299.[19]Wang Y,Zhao X,Liu-Bryan R.Role of TLR2 and TLR4 in regulation of articular chondrocyte homeostasis[J].Osteoarthritis Cartilage,2020,28(5):669-674.[20]Barbour KE,Murphy LB,Helmick CG,et al.Bone Mineral Density and the Risk of Hip and Knee Osteoarthritis: The Johnston County Osteoarthritis Project[J].Arthritis Care Res (Hoboken),2017,69(12):1863-1870.[21]Kalaitzoglou E,Lopes EBP,Fu Y,et al.TLR4 Promotes and DAP12 Limits Obesity-Induced Osteoarthritis in Aged Female Mice[J].JBMR Plus,2018,3(4):e10079.[22]Kalaitzoglou E,Griffin TM,Humphrey MB.Innate Immune Responses and Osteoarthritis[J].Curr Rheumatol Rep,2017,19(8):45.[23]Santangelo KS.Systemic antagonism of toll-like receptor 4 reduces post-traumatic osteoarthritis in a murine model[J].Osteoarthritis Cartilage,2017,25:S14-S15.[24]Vincent TL.IL-1 in osteoarthritis: time for a critical review of the literature[J].F1000Res,2019,8:F1000 Faculty Rev-934.[25]Fleischmann RM,Bliddal H,Blanco FJ,et al.A Phase II Trial of Lutikizumab, an Anti-Interleukin-1α/β Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis[J].Arthritis Rheumatol,2019,71(7):1056-1069.[26]Kaneko N,Kurata M,Yamamoto T,et al.The role of interleukin-1 in general pathology[J].Inflamm Regen,2019,39(1):1-16.[27]Nugent M.MicroRNAs: exploring new horizons in osteoarthritis[J].Osteoarthritis Cartilage,2016,24(4):573-580.[28]Sondag GR,Haqqi TM.The Role of MicroRNAs and Their Targets in Osteoarthritis[J].Curr Rheumatol Rep,2016,18(8):56.[29]Attur M,Statnikov A,Samuels J,et al.Plasma levels of interleukin-1 receptor antagonist (IL1Ra) predict radiographic progression of symptomatic knee osteoarthritis[J].Osteoarthritis Cartilage,2015,23(11):1915-1924.[30]Palomo J,Dietrich D,Martin P,et al.The interleukin (IL)-1 cytokine family--Balance between agonists and antagonists in inflammatory diseases[J].Cytokine,2015,76(1):25-37.[31]Wang Z,Qu Z,Fu C,et al.Interleukin 1 Polymorphisms Contribute to Intervertebral Disc Degeneration Risk: A Meta-Analysis[J].PLoS One,2016,11(6):e0156412.[32]Chen Y,Ma H,Bi D,et al.Association of interleukin 1 gene polymorphism with intervertebral disc degeneration risk in the Chinese Han population[J].Biosci Rep,2018,38(4):BSR20171627.[33]Rose-John S.The Soluble Interleukin 6 Receptor: Advanced Therapeutic Options in Inflammation[J].Clin Pharmacol Ther,2017,102(4):591-598.[34]Jones SA,Jenkins BJ.Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer[J].Nat Rev Immunol,2018,18(12):773-789.[35]McGregor NE,Murat M,Elango J,et al.IL-6 exhibits both cis- and trans-signaling in osteocytes and osteoblasts, but only trans-signaling promotes bone formation and osteoclastogenesis[J].J Biol Chem,2019,294(19):7850-7863.[36]Feng W,Liu H,Luo T,et al.Combination of IL-6 and sIL-6R differentially regulate varying levels of RANKL-induced osteoclastogenesis through NF-κB, ERK and JNK signaling pathways[J].Sci Rep,2017,7:41411.[37]Wang ZW,Chen L,Hao XR,et al.Elevated levels of interleukin-1β, interleukin-6, tumor necrosis factor-α and vascular endothelial growth factor in patients with knee articular cartilage injury[J].World J Clin Cases,2019,7(11):1262-1269.[38]Siqueira MB,Frangiamore S,Klika AK,et al.Comparison of Synovial Fluid Cytokine Levels between Traumatic Knee Injury and End-Stage Osteoarthritis[J].J Knee Surg,2017,30(2):128-133.[39]Cuéllar VG,Cuéllar JM,Kirsch T,et al.Correlation of Synovial Fluid Biomarkers With Cartilage Pathology and Associated Outcomes in Knee Arthroscopy[J].Arthroscopy,2016,32(3):475-485.[40]Laavola M,Lepp?覿nen T,H?覿m?覿l?覿inen M,et al.IL-6 in Osteoarthritis: Effects of Pine Stilbenoids[J].Molecules,2018,24(1):109.[41]Sahu N,Viljoen HJ,Subramanian A.Continuous low-intensity ultrasound attenuates IL-6 and TNFα-induced catabolic effects and repairs chondral fissures in bovine osteochondral explants[J].BMC Musculoskelet Disord,2019,20(1):193.[42]Nasi S,So A,Combes C,et al.Interleukin-6 and chondrocyte mineralisation act in tandem to promote experimental osteoarthritis[J].Ann Rheum Dis,2016,75(7):1372-1379.[43]Pérez-Baos S,Prieto-Potin I,Román-Blas JA,et al.Mediators and Patterns of Muscle Loss in Chronic Systemic Inflammation[J].Front Physiol,2018,9:409.[44]De Ceuninck F,Fradin A,Pastoureau P.Bearing arms against osteoarthritis and sarcopenia: when cartilage and skeletal muscle find common interest in talking together[J].Drug Discov Today,2014,19(3):305-311.[45]He J,Wang L,Ding Y,et al.lncRNA FER1L4 is dysregulated in osteoarthritis and regulates IL-6 expression in human chondrocyte cells[J].Sci Rep,2021,11(1):13032.[46]Teunis T,Beekhuizen M,VanOsch GV,et al.Soluble mediators in posttraumatic wrist and primary knee osteoarthritis[J].Arch Bone Jt Surg,2014,2(3):146-150.[47]Damman W,Liu R,Bloem JL,et al.Bone marrow lesions and synovitis on MRI associate with radiographic progression after 2 years in hand osteoarthritis[J].Ann Rheum Dis,2017,76(1):214-217.[48]Scanzello CR.Role of low-grade inflammation in osteoarthritis[J].Curr Opin Rheumatol,2017,29(1):79-85.[49]Haugen IK,Mathiessen A,Slatkowsky-Christensen B,et al.Synovitis and radiographic progression in non-erosive and erosive hand osteoarthritis: is erosive hand osteoarthritis a separate inflammatory phenotype?[J].Osteoarthritis Cartilage,2016,24(4):647-654.[50]Kamiya N,Kuroyanagi G,Aruwajoye O,et al.IL6 receptor blockade preserves articular cartilage and increases bone volume following ischemic osteonecrosis in immature mice[J].Osteoarthritis Cartilage,2019,27(2):326-335.[51]Pearson MJ,Herndler-Brandstetter D,Tariq MA,et al.IL-6 secretion in osteoarthritis patients is mediated by chondrocyte-synovialfibroblast cross-talk and is enhanced by obesity[J].Sci Rep,2017,7(1):3451.[52]Lehrskov LL,Christensen RH.The role of interleukin-6 in glucose homeostasis and lipid metabolism[J].Semin Immunopathol,2019,41(4):491-499.

更新日期/Last Update: 1900-01-01