[1]余松祚.黄酮类中药干预程序性细胞死亡在缓解脑缺血再灌注损伤中的研究进展[J].医学信息,2023,36(02):171-175.[doi:10.3969/j.issn.1006-1959.2023.02.038]
 YU Song-zuo.Research Progress of Flavonoid Chinese Medicine Intervention in Programmed Cell Death to Alleviate Cerebral Ischemia-reperfusion Injury[J].Journal of Medical Information,2023,36(02):171-175.[doi:10.3969/j.issn.1006-1959.2023.02.038]
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黄酮类中药干预程序性细胞死亡在缓解脑缺血再灌注损伤中的研究进展()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年02期
页码:
171-175
栏目:
综述
出版日期:
2023-01-15

文章信息/Info

Title:
Research Progress of Flavonoid Chinese Medicine Intervention in Programmed Cell Death to Alleviate Cerebral Ischemia-reperfusion Injury
文章编号:
1006-1959(2023)02-0171-05
作者:
余松祚
(贵港市人民医院神经外科,广西 贵港 537100)
Author(s):
YU Song-zuo
(Department of Neurosurgery,Guigang City People’s Hospital,Guigang 537100,Guangxi,China)
关键词:
黄酮类中药脑缺血再灌注损伤程序性细胞死亡
Keywords:
Flavonoid Chinese medicineCerebral ischemia reperfusion injuryProgrammed cell death
分类号:
R741.05
DOI:
10.3969/j.issn.1006-1959.2023.02.038
文献标志码:
A
摘要:
脑缺血再灌注损伤(CIRI)是指缺血性中风再灌注对脑功能造成的有害影响,致残率和死亡率高,其涉及一个动态复杂的病理生理过程,包括:能量代谢障碍、钙超载、线粒体功能障碍、兴奋性氨基酸毒性、程序性细胞死亡等机制。近年来,大量实验研究表明黄酮类中药治疗CIRI具有良好的效果。为深入了解黄酮类中药、程序性细胞死亡以及与CIRI的关系,本文从PubMed数据库、中国知网及万方数据库中查阅相关文献资料,系统阐述黄酮类中药通过干预程序性细胞死亡在CIRI中的研究进展,以期为临床诊治缺血性脑血管病提供新思路。
Abstract:
Cerebral ischemia reperfusion injury (CIRI) refers to the harmful effects of ischemic stroke reperfusion on brain function, with high morbidity and mortality. It involves a dynamic and complex pathophysiological process, including energy metabolism disorder, calcium overload, mitochondrial dysfunction, excitatory amino acid toxicity, programmed cell death and other mechanisms. In recent years, a large number of experimental studies have shown that flavonoids have a good effect in the treatment of CIRI. In order to further understand the relationship between flavonoids, programmed cell death and CIRI, this paper systematically expounds the research progress of flavonoids in CIRI by intervening programmed cell death from PubMed database, CNKI database and Wanfang database, in order to provide new ideas for clinical diagnosis and treatment of ischemic cerebrovascular disease.

参考文献/References:

[1]Feske SK.Ischemic Stroke[J].Am J Med,2021,134(12):1457-1464.[2]Fukuta T,Asai T,Yanagida Y,et al.Combination therapy with liposomal neuroprotectants and tissue plasminogen activator for treatment of ischemic stroke[J].FASEB J,2017,31(5):1879-1890.[3]L L,X W,Z Y.Ischemia-reperfusion Injury in the Brain: Mechanisms and Potential Therapeutic Strategies[J].Biochem Pharmacol (Los Angel),2016,5(4):213.[4]Chamorro ?魣,Dirnagl U,Urra X,et al.Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation[J].Lancet Neurol,2016,15(8):869-881.[5]Jin Z,Guo P,Li X,et al.Neuroprotective effects of irisin against cerebral ischemia/ reperfusion injury via Notch signaling pathway[J].Biomed Pharmacother,2019,120:109452.[6]Xu X,Zhang L,Ye X,et al.Nrf2/ARE pathway inhibits ROS-induced NLRP3 inflammasome activation in BV2 cells after cerebral ischemia reperfusion[J].Inflamm Res,2018,67(1):57-65.[7]Sun K,Fan J,Han J.Ameliorating effects of traditional Chinese medicine preparation, Chinese materia medica and active compounds on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage[J].Acta Pharm Sin B,2015,5(1):8-24.[8]Parmenter BH,Dalgaard F,Murray K,et al.Habitual flavonoid intake and ischemic stroke incidence in the Danish Diet, Cancer, and Health Cohort[J].Am J Clin Nutr,2021,114(1):348-357.[9]Guan X,Li Z,Zhu S,et al.Galangin attenuated cerebral ischemia-reperfusion injury by inhibition of ferroptosis through activating the SLC7A11/GPX4 axis in gerbils[J].Life Sci,2021,264:118660.[10]Lee da H,Lee CS.Flavonoid myricetin inhibits TNF-α-stimulated production of inflammatory mediators by suppressing the Akt, mTOR and NF-κB pathways in human keratinocytes[J].Eur J Pharmacol,2016,784:164-172.[11]Bai Y,Lam HC,Lei X.Dissecting Programmed Cell Death with Small Molecules[J].Acc Chem Res,2020,53(5):1034-1045.[12]Proneth B,Conrad M.Ferroptosis and necroinflammation, a yet poorly explored link[J].Cell Death Differ,2019,26(1):14-24.[13]Li X,Ma N,Xu J,et al.Targeting Ferroptosis: Pathological Mechanism and Treatment of Ischemia-Reperfusion Injury[J].Oxid Med Cell Longev,2021,2021:1587922.[14]DeGregorio-Rocasolano N,Martí-Sistac O,Gasull T.Deciphering the Iron Side of Stroke: Neurodegeneration at the Crossroads Between Iron Dyshomeostasis, Excitotoxicity, and Ferroptosis[J].Front Neurosci,2019,13:85.[15]Yuan Y,Zhai Y,Chen J,et al.Kaempferol Ameliorates Oxygen-Glucose Deprivation/Reoxygenation-Induced Neuronal Ferroptosis by Activating Nrf2/SLC7A11/GPX4 Axis[J].Biomolecules,2021,11(7):923.[16]Guo H,Zhu L,Tang P,et al.Carthamin yellow improves cerebral ischemia reperfusion injury by attenuating inflammation and ferroptosis in rats[J].Int J Mol Med,2021,47(4):52.[17]Guan X,Li X,Yang X,et al.The neuroprotective effects of carvacrol on ischemia/reperfusion-induced hippocampal neuronal impairment by ferroptosis mitigation[J].Life Sci,2019,235:116795.[18]Zheng B,Zhou X,Pang L,et al.Baicalin suppresses autophagy-dependent ferroptosis in early brain injury after subarachnoid hemorrhage[J].Bioengineered,2021,12(1):7794-7804.[19]Jing J,Liu X,Geng X,et al.[Autophagy mechanism of cerebral ischemia injury and intervention of traditional Chinese medicine][J].Chinese Critical Care Medicine,2019,31(10):1299-1301.[20]Huang YG,Tao W,Yang SB,et al.Autophagy: novel insights into therapeutic target of electroacupuncture against cerebral ischemia/ reperfusion injury[J].Neural Regen Res,2019,14(6):954-961.[21]Tao J,Shen C,Sun Y,et al.Neuroprotective effects of pinocembrin on ischemia/reperfusion-induced brain injury by inhibiting autophagy[J].Biomed Pharmacother,2018,106:1003-1010.[22]Yang S,Wang H,Yang Y,et al.Baicalein administered in the subacute phase ameliorates ischemia-reperfusion-induced brain injury by reducing neuroinflammation and neuronal damage[J].Biomed Pharmacother,2019,117:109102.[23]Feng J,Chen X,Lu S,et al.Naringin Attenuates Cerebral Ischemia-Reperfusion Injury Through Inhibiting Peroxynitrite-Mediated Mitophagy Activation[J].Mol Neurobiol,2018,55(12):9029-9042.[24]Hu L,Chen M,Chen X,et al.Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate[J].Cell Death Dis,2020,11(4):281.[25]Lo TH,Chen HL,Yao CI,et al.Galectin-3 promotes noncanonical inflammasome activation through intracellular binding to lipopolysaccharide glycans[J].Proc Natl Acad Sci U S A,2021,118(30):e2026246118.[26]Xu J,Cai S,Zhao J,et al.Advances in the Relationship Between Pyroptosis and Diabetic Neuropathy[J].Front Cell Dev Biol,2021,9:753660.[27]Sun R,Peng M,Xu P,et al.Low-density lipoprotein receptor (LDLR) regulates NLRP3-mediated neuronal pyroptosis following cerebral ischemia/reperfusion injury[J].J Neuroinflammation,2020,17(1):330.[28]Huang L,Li X,Liu Y,et al.Curcumin Alleviates Cerebral Ischemia-reperfusion Injury by Inhibiting NLRP1-dependent Neuronal Pyroptosis[J].Curr Neurovasc Res,2021,18(2):189-196.[29]Kong Y,Feng Z,Chen A,et al.The Natural Flavonoid Galangin Elicits Apoptosis, Pyroptosis, and Autophagy in Glioblastoma[J].Front Oncol,2019,9:942.[30]Hu Q,Zhang T,Yi L,et al.Dihydromyricetin inhibits NLRP3 inflammasome-dependent pyroptosis by activating the Nrf2 signaling pathway in vascular endothelial cells[J].Biofactors,2018,44(2):123-136.[31]Li Y,Song W,Tong Y,et al.Isoliquiritin ameliorates depression by suppressing NLRP3-mediated pyroptosis via miRNA-27a/SYK/NF-κB axis[J].J Neuroinflammation,2021,18(1):1.[32]Rui W,Li S,Xiao H,et al.Baicalein Attenuates Neuroinflammation by Inhibiting NLRP3/caspase-1/GSDMD Pathway in MPTP Induced Mice Model of Parkinson’s Disease [J].Int J Neuropsychopharmacol,2020,23(11):762-773.[33]Xu X,Chua KW,Chua CC,et al.Synergistic protective effects of humanin and necrostatin-1 on hypoxia and ischemia/reperfusion injury[J].Brain Res,2010,1355:189-194.[34]Zhang Q,Jia M,Wang Y,et al.Cell Death Mechanisms in Cerebral Ischemia-Reperfusion Injury[J].Neurochem Res,2022,47(12):3525-3542.[35]Liao S,Apaijai N,Luo Y,et al.Cell death inhibitors protect against brain damage caused by cardiac ischemia/reperfusion injury[J].Cell Death Discov,2021,7(1):312.[36]Yao D,Zhang S,Hu Z,et al.CHIP ameliorates cerebral ischemia-reperfusion injury by attenuating necroptosis and inflammation[J].Aging (Albany NY),2021,13(23):25564-25577.[37]Liao S,Apaijai N,Chattipakorn N,et al.The possible roles of necroptosis during cerebral ischemia and ischemia/reperfusion injury[J].Arch Biochem Biophys,2020,695:108629.[38]Zhang YY,Liu WN,Li YQ,et al.Ligustroflavone reduces necroptosis in rat brain after ischemic stroke through targeting RIPK1/RIPK3/MLKL pathway[J].Naunyn Schmiedebergs Arch Pharmacol,2019,392(9):1085-1095.[39]Adameová A,Pavol M,Pavel S,et al.Effects of Ligustrum delavayanum Hariot. on cholesterol levels and arrhythmogenesis induced by myocardial ischaemia-reperfusion injury in diabetic-hypercholesterolaemic rats[J].Environ Toxicol Pharmacol,2008,26(2):255-258.[40]Wang W,Xie L,Zou X,et al.Pomelo peel oil suppresses TNF-α-induced necroptosis and cerebral ischaemia-reperfusion injury in a rat model of cardiac arrest[J].Pharm Biol,2021,59(1):401-409.[41]Tian XY,Xie L,Wang WY,et al.Pomelo Peel Volatile Oil Alleviates Neuroinflammation on Focal Cerebral Ischemia Reperfusion Injury Rats via Inhibiting TLR4/NF-κB Signaling Pathway[J].Curr Pharm Biotechnol,2021,22(14):1878-1890.

更新日期/Last Update: 1900-01-01