[1]范可煜,李元海,鲁显福,等.影响老年喉鳞状细胞癌患者手术预后的相关因素分析[J].医学信息,2023,36(03):104-108.[doi:10.3969/j.issn.1006-1959.2023.03.021]
 FAN Ke-yu,LI Yuan-hai,LU Xian-fu,et al.Analysis of Related Factors Affecting the Prognosis of Elderly Patients with Laryngeal Squamous Cell Carcinoma[J].Journal of Medical Information,2023,36(03):104-108.[doi:10.3969/j.issn.1006-1959.2023.03.021]
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影响老年喉鳞状细胞癌患者手术预后的相关因素分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年03期
页码:
104-108
栏目:
论著
出版日期:
2023-02-01

文章信息/Info

Title:
Analysis of Related Factors Affecting the Prognosis of Elderly Patients with Laryngeal Squamous Cell Carcinoma
文章编号:
1006-1959(2023)03-0104-05
作者:
范可煜李元海鲁显福
(1.安徽医科大学附属巢湖医院麻醉科,安徽 巢湖 238000;2.安徽医科大学第一附属医院高新院区麻醉科,安徽 合肥 230022)
Author(s):
FAN Ke-yuLI Yuan-haiLU Xian-fuet al.
(1.Department of Anesthesiology,Chaohu Hospital of Anhui Medical University,Chaohu 238000,Anhui,China;2.Department of Anesthesiology,High tech Hospital of the First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui,China)
关键词:
喉鳞状细胞癌盐酸戊乙奎醚5年生存率
Keywords:
Laryngeal squamous cell carcinomaPenehyclidine hydrochloride5-year survival rate
分类号:
R739.65
DOI:
10.3969/j.issn.1006-1959.2023.03.021
文献标志码:
A
摘要:
目的 研究老年喉鳞状细胞癌患者手术后的生存状况及围手术期相关影响因素。方法 回顾性收集2011年3月-2019年8月于安徽医科大学第一附属医院行手术治疗的150例老年喉鳞状细胞癌患者手术、病理以及麻醉相关资料,使用Cox比例风险模型进行单因素及多因素分析,并通过Kaplan-Meier模型绘制相关因素生存曲线,分析影响老年喉鳞状细胞癌患者预后的因素。结果 150例患者5年生存率为44.66%;Cox比例风险模型单因素分析显示,年龄、喉癌TNM分期、肿瘤大小、T分期、N分期、手术方式、盐酸戊乙奎醚是影响老年喉鳞状细胞癌患者手术预后的风险因素;Cox多因素分析显示,年龄、肿瘤大小、手术方式、盐酸戊乙奎醚是影响老年喉鳞状细胞癌患者预后的独立危险因素;Kaplan-Meier生存曲线显示,年龄>70岁患者预后差于60~70岁患者,肿瘤直径>3 cm患者预后差于肿瘤直径≤3 cm患者,全喉切除术患者预后相较于部分喉切除患者差,使用盐酸戊乙奎醚患者预后优于未使用的患者。结论 年龄、肿瘤大小、手术方式、盐酸戊乙奎醚是影响老年喉鳞状细胞癌患者预后的独立危险因素。
Abstract:
Objective To study the survival status of elderly patients with laryngeal squamous cell carcinoma after surgery and the related influencing factors during perioperative period.Methods The surgical, pathological and anesthetic data of 150 elderly patients with laryngeal squamous cell carcinoma who underwent surgical treatment in the First Affiliated Hospital of Anhui Medical University from March 2011 to August 2019 were collected retrospectively. Cox proportional risk model was used for univariate and multivariate analysis, and Kaplan-Meier model was used to draw the survival curve of related factors to analyze the factors affecting the prognosis of elderly patients with laryngeal squamous cell carcinoma.Results The 5-year survival rate of 150 patients was 44.66%. Univariate analysis of Cox proportional hazard model showed that age, TNM stage, tumor size, T stage, N stage, surgical method and penehyclidine hydrochloride were risk factors affecting the prognosis of elderly patients with laryngeal squamous cell carcinoma. Cox multivariate analysis showed that age, tumor size, surgical method and penehyclidine hydrochloride were independent risk factors affecting the prognosis of elderly patients with laryngeal squamous cell carcinoma. Kaplan-Meier survival curve showed that the prognosis of patients aged >70 years was worse than that of patients aged 60-70 years, the prognosis of patients with tumor diameter >3 cm was worse than that of patients with tumor diameter ≤ 3 cm, the prognosis of patients with total laryngectomy was worse than that of patients with partial laryngectomy, and the prognosis of patients with penehyclidine hydrochloride was better than that of patients without penehyclidine hydrochloride.Conclusion Age, tumor size, surgical method and penehyclidine hydrochloride are independent risk factors affecting the prognosis of elderly patients with laryngeal squamous cell carcinoma.

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更新日期/Last Update: 1900-01-01