[1]王良莉,郑贤芳.血HCG、孕酮及雌二醇联合腹部彩超在早期异位妊娠中的诊断价值[J].医学信息,2023,36(11):134-137.[doi:10.3969/j.issn.1006-1959.2023.11.027]
　WANG Liang-li,ZHENG Xian-fang.The Diagnostic Value of Serum HCG, Progesterone and Estradiol Combined with Abdominal Ultrasound in Early-stage Ectopic Pregnancy[J].Journal of Medical Information,2023,36(11):134-137.[doi:10.3969/j.issn.1006-1959.2023.11.027]
点击复制

血HCG、孕酮及雌二醇联合腹部彩超在早期异位妊娠中的诊断价值()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年11期
页码:
134-137
栏目:
诊疗技术
出版日期:
2023-06-01

文章信息/Info

Title:
The Diagnostic Value of Serum HCG, Progesterone and Estradiol Combined with Abdominal Ultrasound in Early-stage Ectopic Pregnancy
文章编号:
1006-1959（2023）11-0134-04
作者:
王良莉; 郑贤芳
（安徽医科大学附属巢湖医院妇产科，安徽 巢湖 238000）
Author(s):
WANG Liang-li; ZHENG Xian-fang
(Department of Obstetrics and Gynecology,Chaohu Hospital of Anhui Medical University,Chaohu 238000,Anhui,China)
关键词:
腹部彩超; 异位妊娠; 雌二醇; 孕酮; 血HCG
Keywords:
Abdominal color Doppler ultrasound; Ectopic pregnancy; Estradiol; Progesterone; Serum HCG
分类号:
R714.22；R445.1
DOI:
10.3969/j.issn.1006-1959.2023.11.027
文献标志码:
A
摘要:
目的 研究血HCG、孕酮及雌二醇在早期异位妊娠中的变化及其联合彩超检查对早期异位妊娠的诊断价值。方法 抽取2020年12月-2022年3月于我院检查并诊断出异位妊娠的56例妇女作为异位妊娠组，并将同期于我院检查并确定正常宫内妊娠的72名妇女作为正常妊娠组，两组均在早上8~10点行血液检测以及彩超检查，比较两组血HCG、孕酮及雌二醇水平以及内膜厚度，对血HCG、孕酮、雌二醇以及内膜厚度单独检测以及联合检测诊断异位妊娠的价值进行分析。结果 异位妊娠组血HCG、孕酮、雌二醇以及彩超内膜厚度均低于正常妊娠组，差异有统计学意义（P＜0.05）；血HCG、孕酮、雌二醇以及超声检查联合检测的灵敏度（94.60%）、特异度（84.70%）以及最大Youden指数（79.40%）高于单项检测。结论 相比于单项检测，血HCG、孕酮及雌二醇以及超声检查在异位妊娠的诊断中具有较高的价值。
Abstract:
Objective To study the changes of serum HCG, progesterone and estradiol in early-stage ectopic pregnancy and the diagnostic value of combined color Doppler ultrasound in early-stage ectopic pregnancy.Methods A total of 56 women who were examined and diagnosed with ectopic pregnancy in our hospital from December 2020 to March 2022 were selected as the ectopic pregnancy group, and 72 women who were examined and diagnosed with normal intrauterine pregnancy in our hospital during the same period were selected as the normal pregnancy group. Blood tests and color Doppler ultrasonography were performed at 8 to 10 o ’clock in the morning. The levels of blood HCG, progesterone, estradiol and endometrial thickness were compared between the two groups. The value of separate detection and combined detection of blood HCG, progesterone, estradiol and endometrial thickness in the diagnosis of ectopic pregnancy was analyzed.Results The levels of HCG, progesterone, estradiol and endometrial thickness in ectopic pregnancy group were lower than those in normal pregnancy group, the difference was statistically significant (P<0.05). The sensitivity (94.60%), specificity (84.70%) and maximum Youden index (79.40%) of combined detection of serum HCG, progesterone, estradiol and ultrasonography were higher than those of single detection.Conclusion Compared with single detection, blood HCG, progesterone, estradiol and ultrasonography have higher value in the diagnosis of ectopic pregnancy.

参考文献/References:

[1]Webster K,Eadon H,Fishburn S,et al.Ectopic pregnancy and miscarriage: diagnosis and initial management: summary of updated NICE guidance[J].BMJ,2019,367(13):l6283.[2]李未今,汪晓华,张乐琴.人绒毛膜促性腺激素、孕酮及子宫内膜厚度联合检测在异位妊娠早期诊断中的价值[J].中国妇幼保健,2020,35(4):700-703.[3]Casikar I,Reid S,Condous G.Ectopic pregnancy: Ultrasound diagnosis in modern management[J].Clin Obstet Gynecol,2012,55(2):402-409.[4]吴立平,程双华,全晖.异位妊娠患者凝血功能和性激素水平分析[J].中国计划生育学杂志,2021,29(11):2376-2377,2383.[5]Farquhar CM.Ectopic pregnancy[J].Lancet,2005,366(9485):583-591.[6]孟临侠,张敏楠,张科勋,等.经阴道及经腹部彩色多普勒超声联合人绒毛膜促性腺激素和孕酮含量检测在异位妊娠诊断中的价值[J].中国妇幼保健,2018,33(12):2823-2826.[7]董丽丽,李银凤,刘改文,等.阴道超声联合血清β-HCG、P水平检测对输卵管妊娠早期患者诊断符合率的影响[J].中国性科学,2019,28(4):54-58[8]Mandalà M.Influence of Estrogens on Uterine Vascular Adaptation in Normal and Preeclamptic Pregnancies[J].Int J Mol Sci,2020,21(7):2592. [9]Xia H,Zhang W.Luteal phase deficiency during the early trimester in a case with secondary hypopituitarism following craniopharyngioma resection[J].J Obstet Gynaecol Res,2021,47(9):3379-3384.[10]王玉东,陆琦.输卵管妊娠诊治的中国专家共识[J].中国实用妇科与产科杂志,2019,35(7):780-787.[11]Exler S,Daiminger A,Grothe M,et al.Primary cytomegalovirus (CMV) infection in pregnancy: Diagnostic value of CMV PCR in saliva compared to urine at birth[J].J Clin Virol,2019,117:33-36. [12]Puget C,Joueidi Y,Bauville E,et al.Serial hCG and progesterone levels to predict early pregnancy outcomes in pregnancies of uncertain viability: A prospective study[J].Eur J Obstet Gynecol Reprod Biol,2018,220:100-105.[13]杜云芳,周红梅,郑笑,等.三种不同超声方法对异位妊娠的诊断价值[J].中国妇幼健康研究,2019,30(6):752-755.[14]张春雨,郑永财,杨小君,等.阴道超声结合血清β-HCG、孕酮、E2对异位妊娠的早期诊断价值[J].检验医学与临床,2018,15(3):297-300.[15]王洪玲,张琰.早期异位妊娠患者β-HCG、E2和P水平变化及预测分析[J].现代预防医学,2019,46(1):58-61.[16]马瑞琳.体外受精—胚胎移植后异位妊娠风险相关因素分析[D].济南:山东大学,2018.[17]Ilicic M,Zakar T,Paul JW.The Regulation of Uterine Function During Parturition: an Update and Recent Advances[J].Reprod Sci,2020,27(1):3-28. [18]Rosselli M,Cometti BPS,Leeners B,et al.Modulation of Cyclic AMP Levels in Fallopian Tube Cells by Natural and Environmental Estrogens[J].Cells,2021,10(5):1250.[19]叶楠,周琪.阴道彩超联合血清HCG、孕酮检测评估早期异位妊娠分析[J].中国计划生育学杂志,2021,29(5):1029-1031,1036,1081.[20]刘绪园.孕酮、雌激素及β-hCG联合检测对早期异位妊娠的诊断价值[J].实验与检验医学,2019,37(4):706-707.

相似文献/References:

[1]韩玉英.腹腔镜下输卵管切开取胚联合输卵管通液术对远期妊娠的影响[J].医学信息,2018,31(21):109.[doi:10.3969/j.issn.1006-1959.2018.21.030]
　HAN Yu-ying.Effect of Embryo Extraction by Laparoscopic Oviduct Incision Combined with Hydrotubation on Long-term Pregnancy[J].Journal of Medical Information,2018,31(11):109.[doi:10.3969/j.issn.1006-1959.2018.21.030]
[2]黄 琼.阴道彩超联合血清孕酮、β-HCG及CA125对异位妊娠的诊断价值[J].医学信息,2018,31(24):128.[doi:10.3969/j.issn.1006-1959.2018.24.037]
　HUANG Qiong.Clinical Value of Vaginal Color Ultrasound Combined with Serum Progesterone,β-HCG and CA125 in the Diagnosis of Ectopic Pregnancy[J].Journal of Medical Information,2018,31(11):128.[doi:10.3969/j.issn.1006-1959.2018.24.037]
[3]韦 林,赵军玲,宾 力,等.异位妊娠腹腔镜镜像与TVS表现及 血清β-HCG表达的相关性研究[J].医学信息,2019,32(12):85.[doi:10.3969/j.issn.1006-1959.2019.12.026]
　WEI Lin,ZHAO Jun-ling,BIN Li,et al.Correlation Research between Laparoscopic Mirror Image of Ectopic Pregnancy and TVS Expression and Serum β-HCG Expression[J].Journal of Medical Information,2019,32(11):85.[doi:10.3969/j.issn.1006-1959.2019.12.026]
[4]徐小芳.经阴道超声检查对异位妊娠的诊断价值分析[J].医学信息,2022,35(18):144.[doi:10.3969/j.issn.1006-1959.2022.18.040]
　XU Xiao-fang.Diagnostic Value of Transvaginal Ultrasonography in Ectopic Pregnancy[J].Journal of Medical Information,2022,35(11):144.[doi:10.3969/j.issn.1006-1959.2022.18.040]
[5]叶瑛瑛,王金辉,谢灵平.miRNA-323-3p联合miRNA-873在异位妊娠早期诊断中的价值研究[J].医学信息,2022,35(22):72.[doi:10.3969/j.issn.1006-1959.2022.22.012]
　YE Ying-ying,WANG Jin-hui,XIE Ling-ping.The Value of miRNA-323-3p Combined with miRNA-873 in Early Diagnosis of Ectopic Pregnancy[J].Journal of Medical Information,2022,35(11):72.[doi:10.3969/j.issn.1006-1959.2022.22.012]
[6]吴传慧,吴传芬.经腹部联合阴道超声在妇产科急腹症诊断中的应用价值[J].医学信息,2022,35(24):154.[doi:10.3969/j.issn.1006-1959.2022.24.034]
　WU Chuan-hui,WU Chuan-fen.The Application Value of Transabdominal Combined with Transvaginal Ultrasound in the Diagnosis of Acute Abdomen in Obstetrics and Gynecology Department[J].Journal of Medical Information,2022,35(11):154.[doi:10.3969/j.issn.1006-1959.2022.24.034]
[7]李 璟,光晓燕,于 琳,等.二孩政策实施前后异位妊娠临床特征的变化分析[J].医学信息,2023,36(23):13.[doi:10.3969/j.issn.1006-1959.2023.23.004]
　LI Jing,GUANG Xiao-yan,YU Lin,et al.Changes of Clinical Characteristics of Ectopic Pregnancy Before and After the Implementation of the Two-child Policy[J].Journal of Medical Information,2023,36(11):13.[doi:10.3969/j.issn.1006-1959.2023.23.004]
[8]刘 爽.阴道彩超与腹部彩超诊断异位妊娠的临床价值分析[J].医学信息,2018,31(08):159.[doi:10.3969/j.issn.1006-1959.2018.08.056]
　LIU Shuang.Clinical Value of Vaginal Color Doppler Ultrasonography and Abdominal Color Doppler Ultrasound in the Diagnosis of Ectopic Pregnancy[J].Journal of Medical Information,2018,31(11):159.[doi:10.3969/j.issn.1006-1959.2018.08.056]
[9]林 华,郑 珺.阴道彩超在异位妊娠早期筛查中的声像特征及诊断效能分析[J].医学信息,2022,35(22):145.[doi:10.3969/j.issn.1006-1959.2022.22.035]
　LIN Hua,ZHENG Jun.Ultrasonographic Features and Diagnostic Efficiency of Transvaginal Ultrasonography in Early Screening of Ectopic Pregnancy[J].Journal of Medical Information,2022,35(11):145.[doi:10.3969/j.issn.1006-1959.2022.22.035]

更新日期/Last Update: 1900-01-01