[1]晏艳平,许小兵,刘敏鹃.安神益智针法联合电刺激对血管性痴呆患者的认知功能、氧自由基及IL-6的影响[J].医学信息,2023,36(18):94-98.[doi:10.3969/j.issn.1006-1959.2023.18.017]
　YAN Yan-ping,XU Xiao-bing,LIU Min-juan.Effects of Anshen Yizhi Acupuncture Combined with Electrical Stimulation on Cognitive Function,Oxygen Free Radical and IL-6 in Patients with Vascular Dementia[J].Journal of Medical Information,2023,36(18):94-98.[doi:10.3969/j.issn.1006-1959.2023.18.017]
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安神益智针法联合电刺激对血管性痴呆患者的认知功能、氧自由基及IL-6的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年18期
页码:
94-98
栏目:
论著
出版日期:
2023-09-15

文章信息/Info

Title:
Effects of Anshen Yizhi Acupuncture Combined with Electrical Stimulation on Cognitive Function,Oxygen Free Radical and IL-6 in Patients with Vascular Dementia
文章编号:
1006-1959（2023）18-0094-05
作者:
晏艳平; 许小兵; 刘敏鹃
（上高县中医院针灸康复科1，骨伤科2，妇产科3，江西 上高 336400）
Author(s):
YAN Yan-ping; XU Xiao-bing; LIU Min-juan
(Department of Acupuncture and Rehabilitation1,Department of Orthopaedics2,Department of Obstetrics and Gynecology3,Shanggao County Hospital of Traditional Chinese Medicine,Shanggao 336400,Jiangxi,China)
关键词:
安神益智针法; 电刺激; 血管性痴呆; 认知功能; 氧自由基
Keywords:
Anshen Yizhi acupuncture; Electrical stimulation; Vascular dementia; Cognitive function; Oxygen free radical
分类号:
R749.1+3
DOI:
10.3969/j.issn.1006-1959.2023.18.017
文献标志码:
A
摘要:
目的 研究安神益智针法联合电刺激对血管性痴呆患者的认知功能、氧自由基及IL-6的影响。方法 选取2021年3月-2022年3月在我院诊治的120例血管性痴呆患者为研究对象，采用随机数字表法分为对照组（n=40）、治疗组（n=40）、药物组（n=40）。药物组采用常规药物治疗，对照组在药物组基础上给予常规头皮联合电刺激治疗，治疗组在药物组治疗基础上实施安神益智针法联合电刺激治疗，比较3组临床疗效、简易智力状态（MMSE）评分、蒙特利尔认知评估量表（MoCA）、日常生活活动能力指数（BI）、氧自由基（SOD）水平、白细胞介素-6（IL-6）水平、生活质量评分（GQOLI-74）以及不良反应发生率。结果 治疗组治疗总有效率为92.50%，高于对照组的80.00%和药物组的72.50%（P＜0.05）；3组治疗后MMSE评分均高于治疗前，且治疗组高于对照组、药物组（P＜0.05）；3组治疗后MoCA评分、BI评分均高于治疗前，且治疗组高于对照组、药物组（P＜0.05）；3组治疗后血清SOD水平均高于治疗前，血清IL-6均低于治疗前，且治疗组血清SOD高于对照组、药物组，血清IL-6低于对照组、药物组（P＜0.05）；3组治疗后GQOLI-74评分均高于治疗前，且治疗组高于对照组、药物组（P＜0.05）；治疗组不良反应发生率为7.50%，与对照组的5.00%、药物组的5.00%比较，差异无统计学意义（P＞0.05）。结论 安神益智针法联合电刺激治疗血管性痴呆效果确切，可提高治疗总有效率，改善患者认知功能、智力水平，提高氧自由基水平，降低炎症因子水平，提升日常生活能力，且不会增加不良反应发生率，是一种安全、有效的治疗方法，值得临床应用。
Abstract:
Objective To study the effect of Anshen Yizhi acupuncture combined with electrical stimulation on cognitive function, oxygen free radical and IL-6 in patients with vascular dementia.Methods A total of 120 patients with vascular dementia diagnosed and treated in our hospital from March 2021 to March 2022 were selected as the research objects. They were divided into control group (n=40), treatment group (n=40) and drug group (n=40) by random number table method. The drug group was treated with conventional drugs, the control group was treated with conventional scalp combined with electrical stimulation on the basis of the drug group, and the treatment group was treated with Anshen Yizhi acupuncture combined with electrical stimulation on the basis of the drug group. The clinical efficacy, Mini-mental State Examination (MMSE) score, Montreal Cognitive Assessment Scale ( MoCA ), activity of daily living index (BI), super oxide dismutase (SOD) level, interleukin-6 (IL-6) level, quality of life score (GQOLI-74) and incidence of adverse reactions were compared among the three groups.Results The total effective rate of treatment in the treatment group was 92.50%, which was higher than 80.00% in the control group and 72.50% in the drug group (P<0.05). The MMSE score of the three groups after treatment was higher than those before treatment, and that in the treatment group was higher than that in the control group and the drug group (P<0.05). The MoCA score and BI score of the three groups after treatment were higher than those before treatment, and those in the treatment group were higher than those in the control group and the drug group (P<0.05).The level of serum SOD in the three groups after treatment was higher than those before treatment, and the level of serum IL-6 was lower than those before treatment, while the level of serum SOD in the treatment group was higher than that in the control group and the drug group, and the level of serum IL-6 was lower than that in the control group and the drug group (P<0.05). The GQOLI-74 score of the three groups after treatment was higher than that before treatment, and that in the treatment group was higher than that in the control group and the drug group (P<0.05). The incidence of adverse reactions in the treatment group was 7.50%, which was compared with 5.00% in the control group and 5.00% in the drug group, the difference was not statistically significant (P>0.05).Conclusion Anshen Yizhi acupuncture combined with electrical stimulation is effective in the treatment of vascular dementia, which can improve the total effective rate of treatment, improve the cognitive function and intelligence level of patients, improve the level of oxygen free radicals, reduce the level of inflammatory factors, improve the ability of daily life, and will not increase the incidence of adverse reactions. It is a safe and effective treatment method and is worthy of clinical application.

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更新日期/Last Update: 1900-01-01