[1]李元庆,付亚宁,张丽娟,等.VEGF、IL-5、IL-6在鼻息肉中的表达和意义[J].医学信息,2023,36(21):86-89.[doi:10.3969/j.issn.1006-1959.2023.21.019]
　LI Yuan-qing,FU Ya-ning,ZHANG Li-juan,et al.Expression and Significance of VEGF, IL-5, IL-6 in Nasal Polyps[J].Journal of Medical Information,2023,36(21):86-89.[doi:10.3969/j.issn.1006-1959.2023.21.019]
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VEGF、IL-5、IL-6在鼻息肉中的表达和意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年21期
页码:
86-89
栏目:
论著
出版日期:
2023-11-01

文章信息/Info

Title:
Expression and Significance of VEGF, IL-5, IL-6 in Nasal Polyps
文章编号:
1006-1959（2023）21-0086-04
作者:
李元庆; 付亚宁; 张丽娟; 等
（1.昌邑市人民医院耳鼻喉科，山东 昌邑 261300；2.昌邑市人民医院口腔修复科，山东 昌邑 261300；3.昌邑市人民医院查体中心，山东 昌邑 261300；4.陆军第八十集团军医院神经内科，山东 潍坊 261041；5.潍坊市人民医院病理科，山东 潍坊 261041）
Author(s):
LI Yuan-qing; FU Ya-ning; ZHANG Li-juan; et al.
(1.Department of Otorhinolaryngology,Changyi People’s Hospital,Changyi 261300,Shandong,China;2.Department of Prosthodontics,Changyi People’s Hospita,Changyi 261300,Shandong,China;3.Department of Regular Physical Examination Centre,Changyi People’s Hospital,Changyi 261300,Shandong,China;4.Department of Internal Medicine-Neurology,Eightieth Group Army Hospital of PLA,Weifang 261041,Shandong,China;5.Department of Pathology,Weifang People’s Hospital,Weifang 261041,Shandong,China)
关键词:
鼻息肉; VEGF; IL-5; IL-6
Keywords:
Nasal polyps; VEGF; IL-5; IL-6
分类号:
R765
DOI:
10.3969/j.issn.1006-1959.2023.21.019
文献标志码:
A
摘要:
目的 检测鼻息肉患者血清中IL-5和IL-6及鼻息肉组织中VEGF的表达水平。方法 选取2018年1月-2021年12月在昌邑市人民医院就诊并经手术治疗的鼻息肉和鼻腔鼻窦粘膜活检标本60例，其中鼻息肉患者33例作为观察组，正常粘膜27例作为对照组。采取免疫组织化学方法检测两组组织中VEGF的表达，用ELISA试验检测两组血清IL-5、IL-6水平，分析VEGF、IL-5、IL-6与患者年龄、性别、病理分型的关系及VEGF与IL-5、IL-6的相关性。结果 观察组鼻息肉组织中VEGF及血清IL-5、IL-6的表达水平高于对照组（P＜0.05）；VEGF、IL-5、IL-6的表达水平与息肉病理类型、患者年龄、性别无关（P＞0.05）； VEGF的表达与IL-5（r=0.351）、IL-6（r=0.380）的表达均呈正相关。结论 鼻息肉组织中VEGF及患者血清IL-5、IL-6的表达升高，VEGF的表达分别与IL-5、IL-6呈正相关。VEGF、IL-5、IL-6参与了鼻息肉的形成和发生发展。
Abstract:
Objective To detect the expression levels of IL-5 and IL-6 in serum of patients with nasal polyps and VEGF in nasal polyps.Methods From January 2018 to December 2021, 60 cases of nasal polyps and nasal sinus mucosa biopsy specimens treated by surgery in Changyi People’s Hospital were selected, including 33 cases of nasal polyps as observation group and 27 cases of normal mucosa as control group. The expression of VEGF in the tissues of the two groups was detected by immunohistochemistry. The levels of serum IL-5 and IL-6 in the two groups were detected by ELISA. The relationship between VEGF, IL-5 and IL-6 and the age, sex and pathological type of the patients and the correlation between VEGF and IL-5 and IL-6 were analyzed.Results The expression levels of VEGF in nasal polyps and serum IL-5 and IL-6 in the observation group were higher than those in the control group (P<0.05). The expression levels of VEGF, IL-5 and IL-6 were not related to the pathological type of polyps, age and gender of patients (P>0.05). While, the expression of VEGF was positively correlated with the expression of IL-5 (r=0.351) and IL-6 (r=0.380).Conclusion The expression of VEGF in nasal polyps and serum IL-5 and IL-6 in patients increased, and the expression of VEGF is positively correlated with IL-5 and IL-6, respectively. VEGF, IL-5 and IL-6 are involved in the formation and development of nasal polyps.

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更新日期/Last Update: 1900-01-01