参考文献/References:
[1]Shin JI,Lee KH,Joo YH,et al.Inflammasomes and autoimmune and rheumatic diseases:A comprehensive review[J].J Autoimmun,2019,103:102299.[2]Okamoto K,Nakashima T,Shinohara M,et al.Osteoimmunology: The Conceptual Framework Unifying the Immune and Skeletal Systems[J].Physiol Rev,2017,97(4):1295-1349.[3]Tsukasaki M,Takayanagi H.Osteoimmunology: evolving concepts in bone-immune interactions in health and disease[J].Nat Rev Immunol,2019,19(10):626-642.[4]Dar HY,Azam Z,Anupam R,et al.Osteoimmunology: The Nexus between bone and immune system[J].Front Biosci (Landmark Ed),2018,23(3):464-492.[5]Jung YK,Kang YM,Han S.Osteoclasts in the Inflammatory Arthritis: Implications for Pathologic Osteolysis[J].Immune Netw,2019,19(1):e2.[6]Greenblatt MB,Shim JH.Osteoimmunology: a brief introduction[J].Immune Netw,2013,13(4):111-115.[7]Chen G,Shaw MH,Kim YG,et al.NOD-like receptors: role in innate immunity and inflammatory disease[J].Annu Rev Pathol,2009,4:365-398.[8]Wang S,Wang H,Feng C,et al.The regulatory role and therapeutic application of pyroptosis in musculoskeletal diseases[J].Cell Death Discov,2022,8(1):492.[9]Mbalaviele G,Novack DV,Schett G,et al.Inflammatory osteolysis: a conspiracy against bone[J].J Clin Invest,2017,127(6):2030-2039.[10]Sui J,Li H,Fang Y,et al.NLRP1 gene polymorphism influences gene transcription and is a risk factor for rheumatoid arthritis in han chinese[J].Arthritis Rheum,2012,64(3):647-654.[11]Zhu L,Li J,Guo L,et al.Activation of NALP1 inflammasomes in rats with adjuvant arthritis; a novel therapeutic target of carboxyamidotriazole in a model of rheumatoid arthritis[J].Br J Pharmacol,2015,172(13):3446-3459.[12]Zhang W,Cong XL,Qin YH,et al.IL-18 upregulates the production of key regulators of osteoclastogenesis from fibroblast-like synoviocytes in rheumatoid arthritis[J].Inflammation,2013,36(1):103-109.[13]Amin MA,Rabquer BJ,Mansfield PJ,et al.Interleukin 18 induces angiogenesis in vitro and in vivo via Src and Jnk kinases[J].Ann Rheum Dis,2010,69(12):2204-2212.[14]Fan C,Zhao X,Guo X,et al.P2X4 promotes interleukin-1β production in osteoarthritis via NLRP1[J].Mol Med Rep,2014,9(1):340-344.[15]Kitamura A,Sasaki Y,Abe T,et al.An inherited mutation in NLRC4 causes autoinflammation in human and mice[J].J Exp Med,2014,211(12):2385-2396.[16]Rocha FRG,Delitto AE,de Souza JAC,et al.NLRC4 inflammasome has a protective role on inflammatory bone resorption in a murine model of periodontal disease[J].Immunobiology,2020,225(1):151855.[17]Alippe Y,Kress D,Ricci B,et al.Actions of the NLRP3 and NLRC4 inflammasomes overlap in bone resorption[J].FASEB J,2021,35(9):e21837.[18]Levy M,Shapiro H,Thaiss CA,et al.NLRP6: A Multifaceted Innate Immune Sensor[J].Trends Immunol,2017,38(4):248-260.[19]Lu WL,Zhang L,Song DZ,et al.NLRP6 suppresses the inflammatory response of human periodontal ligament cells by inhibiting NF-κB and ERK signal pathways[J].Int Endod J,2019,52(7):999-1009.[20]Lin Y,Luo Z.NLRP6 facilitates the interaction between TAB2/3 and TRIM38 in rheumatoid arthritis fibroblast-like synoviocytes[J].FEBS Lett,2017,591(8):1141-1149.[21]Shen M,Tang L,Shi X,et al.NLRP12 autoinflammatory disease: a Chinese case series and literature review[J].Clin Rheumatol,2017,36(7):1661-1667.[22]Vladimer GI,Weng D,Paquette SW,et al.The NLRP12 inflammasome recognizes Yersinia pestis[J].Immunity,2012,37(1):96-107.[23]Krauss JL,Zeng R,Hickman-Brecks CL,et al.NLRP12 provides a critical checkpoint for osteoclast differentiation[J].Proc Natl Acad Sci U S A,2015,112(33):10455-10460.[24]Taira TM,Lima V,Prado DS,et al.NLRP12 Attenuates Inflammatory Bone Loss in Experimental Apical Periodontitis[J].J Dent Res,2019,98(4):476-484.[25]Zhang X,Nan H,Guo J,et al.NLRP12 reduces proliferation and inflammation of rheumatoid arthritis fibroblast-like synoviocytes by regulating the NF-κB and MAPK pathways[J].Eur Cytokine Netw,2021,32(2):15-22.[26]Pinto LG,Cunha TM,Vieira SM,et al.IL-17 mediates articular hypernociception in antigen-induced arthritis in mice[J].Pain,2010,148(2):247-256.[27]Prado DS,Veras FP,Ferreira RG,et al.NLRP12 controls arthritis severity by acting as a checkpoint inhibitor of Th17 cell differentiation[J].FASEB J,2020,34(8):10907-10919.[28]Joosten LA,Heinhuis B,Abdollahi-Roodsaz S,et al.Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis[J].Proc Natl Acad Sci U S A,2008,105(26):9017-9022.[29]Kim HW,Kwon YJ,Park BW,et al.Differential expressions of NOD-like receptors and their associations with inflammatory responses in rheumatoid arthritis[J].Clin Exp Rheumatol,2017,35(4):630-637.[30]Napier RJ,Lee EJ,Vance EE,et al.Nod2 Deficiency Augments Th17 Responses and Exacerbates Autoimmune Arthritis[J].J Immunol,2018,201(7):1889-1898.[31]Kugyelka R,Kohl Z,Olasz K,et al.Enigma of IL-17 and Th17 Cells in Rheumatoid Arthritis and in Autoimmune Animal Models of Arthritis[J].Mediators Inflamm,2016,2016:6145810.[32]Xu J,Jiang C,Zhu W,et al.NOD2 pathway via RIPK2 and TBK1 is involved in the aberrant catabolism induced by T-2 toxin in chondrocytes[J].Osteoarthritis Cartilage,2015,23(9):1575-1585.[33]Ospelt C,Brentano F,Jüngel A,et al.Expression, regulation, and signaling of the pattern-recognition receptor nucleotide-binding oligomerization domain 2 in rheumatoid arthritis synovial fibroblasts[J].Arthritis Rheum,2009,60(2):355-363.[34]Dinarello CA.Immunological and inflammatory functions of the interleukin-1 family[J].Annu Rev Immunol,2009,27:519-550.[35]Bonar SL,Brydges SD,Mueller JL,et al.Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice[J].PLoS One,2012,7(4):e35979.[36]Jiang N,An J,Yang K,et al.NLRP3 Inflammasome: A New Target for Prevention and Control of Osteoporosis?[J].Front Endocrinol (Lausanne),2021,12:752546.[37]Zhang QB,Qing YF,He YL,et al.Association of NLRP3 polymorphisms with susceptibility to primary gouty arthritis in a Chinese Han population[J].Clin Rheumatol,2018,37(1):235-244.[38]Hornung V,Bauernfeind F,Halle A,et al.Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization[J].Nat Immunol,2008,9(8):847-856.[39]So AK,Martinon F.Inflammation in gout: mechanisms and therapeutic targets[J].Nat Rev Rheumatol,2017,13(11):639-647.[40]Chen CJ,Shi Y,Hearn A,et al.MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals[J].J Clin Invest,2006,116(8):2262-2271.[41]Dong X,Zheng Z,Lin P,et al.ACPAs promote IL-1β production in rheumatoid arthritis by activating the NLRP3 inflammasome[J].Cell Mol Immunol,2020,17(3):261-271.[42]Vande Walle L,Van Opdenbosch N,Jacques P,et al.Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis[J].Nature,2014,512(7512):69-73.[43]Denoble AE,Huffman KM,Stabler TV,et al.Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation[J].Proc Natl Acad Sci U S A,2011,108(5):2088-2093.[44]Wannamaker W,Davies R Namchuk M,et al.(S)-1-((S)-2-{[1-(4-amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an orally available selective interleukin (IL)-converting enzyme/caspase-1 inhibitor, exhibits potent anti-inflammatory activities by inhibiting the release of IL-1beta and IL-18[J].J Pharmacol Exp Ther,2007,321(2):509-516.[45]Joosten LA,Netea MG,Fantuzzi G,et al.Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta[J].Arthritis Rheum,2009,60(12):3651-3662.[46]Kim HY,Kim KS,Kim MJ,et al.Auranofin Inhibits RANKL-Induced Osteoclastogenesis by Suppressing Inhibitors of κB Kinase and Inflammasome-Mediated Interleukin-1β Secretion[J].Oxid Med Cell Longev,2019,2019:3503912.[47]Swanson KV,Deng M,Ting JP.The NLRP3 inflammasome: molecular activation and regulation to therapeutics[J].Nat Rev Immunol,2019,19(8):477-489.[48]He H,Jiang H,Chen Y,et al.Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity[J].Nat Commun,2018,9(1):2550.[49]Goldberg EL,Asher JL,Molony RD,et al.β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares[J].Cell Rep,2017,18(9):2077-2087.[50]Li Q,Feng H,Wang H,et al.Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7-NLRP3 interaction[J].EMBO Rep,2022,23(2):e53499.[51]Arioz BI,Tarakcioglu E,Olcum M,et al.The Role of Melatonin on NLRP3 Inflammasome Activation in Diseases[J].Antioxidants (Basel),2021,10(7):1020.