[1]黄海燕.甲硝唑凝胶联合益生菌治疗细菌性阴道炎的疗效及对阴道微环境的影响[J].医学信息,2024,37(05):134-137.[doi:10.3969/j.issn.1006-1959.2024.05.024]
　HUANG Hai-yan.Efficacy of Metronidazole Gel Combined with Probiotics in the Treatment of Bacterial Vaginitis and its Effect on Vaginal Microenvironment[J].Journal of Medical Information,2024,37(05):134-137.[doi:10.3969/j.issn.1006-1959.2024.05.024]
点击复制

甲硝唑凝胶联合益生菌治疗细菌性阴道炎的疗效及对阴道微环境的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年05期
页码:
134-137
栏目:
论著
出版日期:
2024-03-01

文章信息/Info

Title:
Efficacy of Metronidazole Gel Combined with Probiotics in the Treatment of Bacterial Vaginitis and its Effect on Vaginal Microenvironment
文章编号:
1006-1959（2024）05-0134-04
作者:
黄海燕
（贵溪市妇幼保健院妇产科，江西 贵溪 335400）
Author(s):
HUANG Hai-yan
(Department of Obstetrics and Gynecology,Guixi Maternal and Child Health Hospital,Guixi 335400,Jiangxi,China)
关键词:
细菌性阴道炎; 甲硝唑凝胶; 益生菌; 阴道微环境; 阴道清洁度
Keywords:
Bacterial vaginitis; Metronidazole gel; Probiotics; Vaginal microenvironment; Vaginal cleanliness
分类号:
R711.31
DOI:
10.3969/j.issn.1006-1959.2024.05.024
文献标志码:
A
摘要:
目的 探究甲硝唑凝胶联合益生菌治疗细菌性阴道炎（BV）的临床疗效及对阴道微环境的影响。方法 收集2019年11月-2022年11月贵溪市妇幼保健院收治的60例BV患者，按照随机数字表法分为对照组与观察组，各30例。对照组给予甲硝唑凝胶治疗，观察组在其基础上联合益生菌治疗，比较两组临床疗效、症状改善情况（外阴瘙痒、阴道灼热、鱼腥臭味、白带异常）、阴道微环境（阴道pH值、阴道分泌物Nugent 评分）、阴道清洁度及复发情况。结果 观察组总有效率高于对照组（P＜0.05）；观察组症状缓解时间（外阴瘙痒、阴道灼热、鱼腥臭味、白带异常）短于对照组（P＜0.05）；两组治疗后阴道pH值、Nugent评分均低于治疗前，且观察组阴道pH值、Nugent评分低于对照组（P＜0.05）；两组治疗后阴道清洁度正常率均高于治疗前，且观察组阴道清洁度正常率高于对照组（P＜0.05）；治疗后3个月，观察组复发率低于对照组（P＜0.05）。结论 甲硝唑凝胶联合益生菌治疗细菌性阴道炎疗效确切，可加快症状缓解，改善阴道微环境与清洁度，降低患者的复发率。
Abstract:
Objective To investigate the clinical efficacy of metronidazole gel combined with probiotics in the treatment of bacterial vaginitis (BV) and its effect on vaginal microenvironment.Methods A total of 60 BV patients admitted to Guixi Maternal and Child Health Hospital from November 2019 to November 2022 were collected and divided into control group and observation group according to random number table method, with 30 patients in each group. The control group was treated with metronidazole gel, and the observation group was treated with probiotics on the basis of the control group. The clinical efficacy, symptom improvement (vulva pruritus, vaginal burning, fishy odor, abnormal leucorrhea), vaginal microenvironment (vaginal pH value, vaginal secretion Nugent score), vaginal cleanliness and recurrence were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group (P<0.05). The symptoms relief time (vulva pruritus, vaginal burning, fishy odor, abnormal leucorrhea) in the observation group were shorter than those in the control group (P<0.05). After treatment, the vaginal pH value and Nugent score of the two groups were lower than those before treatment, and the vaginal pH value and Nugent score of the observation group were lower than those of the control group (P<0.05). The normal rate of vaginal cleanliness in the two groups after treatment was higher than that before treatment, and the normal rate of vaginal cleanliness in the observation group was higher than that in the control group (P<0.05). At 3 months after treatment, the recurrence rate of the observation group was lower than that of the control group (P<0.05).Conclusion Metronidazole gel combined with probiotics is effective in the treatment of bacterial vaginitis, which can accelerate symptom relief, improve vaginal microenvironment and cleanliness, and reduce the recurrence rate of patients.

参考文献/References:

[1]汪春燕,何珊,范凌晔.细菌性阴道炎感染病原菌分布及耐药性分析[J].中国病原生物学杂志,2022,17(12):1435-1437,1441.[2]Govinden G,Parker JL,Naylor KL,et al.Inhibition of sialidase activity and cellular invasion by the bacterial vaginosis pathogen Gardnerella vaginalis[J].Arch Microbiol,2018,200(7):1129-1133.[3]徐珍,尚娜.加味知柏地黄汤联合甲硝唑凝胶治疗老年复发性细菌性阴道炎的临床疗效及安全性观察[J].贵州医药,2022,46(10):1622-1623.[4]Landlinger C,Tiáková L,Oberbauer V,et al.Metronidazole Resistance Is a Major Impediment for the Antibiotic Therapy in Bacterial Vaginosis and May Be Overcome with The Gardnerella-Specific Endolysin PM-477[J].American Journal of Obstetrics and Gynecology,2022,226(2):296.[5]唐静,慕冰楠,梁静.乳酸菌阴道胶囊联合硝呋太尔片治疗老年细菌性阴道炎的效果[J].中国医药导报,2021,18(15):121-124.[6]戴晓晓,杜珂珂,赵静,等.乳杆菌活菌胶囊联合抗生素治疗细菌性阴道炎的疗效及复发情况分析[J].中国妇幼保健,2020,35(11):2058-2060.[7]中华医学会妇产科学分会感染性疾病协作组,薛凤霞.细菌性阴道病诊治指南(2021修订版)[J].中华妇产科杂志,2021,56(1):3-6.[8]谭建媛,阳莉,邓凯兮.阴道用乳酸菌胶囊辅助硝呋太尔对老年细菌性阴道炎患者氧化应激反应及阴道灌洗液TLR2、TNF-α、IL-13水平的影响[J].临床和实验医学杂志,2020,19(18):1987-1991.[9]王荐,施美满.雌激素联合甲硝唑对老年女性阴道炎患者阴道微生态的改善效果研究[J].中国妇幼保健,2020,35(3):445-447.[10]张华杰,丁淼,何宏舸,等.细菌性阴道病菌群特点及感染因素分析[J].中国病原生物学杂志,2022,17(8):968-971,977.[11]张丽芳.孕早期甲硝唑凝胶治疗对细菌性阴道炎孕妇妊娠结局的影响[J].中国药物与临床,2020,20(14):2396-2398.[12]黄晓宇,李桂梅,李华维.女性细菌性阴道病的流行病学调查及阴道分泌物检测结果分析[J].宁夏医科大学学报,2021,43(4):377-381.[13]Borgogna J,Shardell MD,Grace SG,et al.Biogenic Amines Increase the Odds of Bacterial Vaginosis and Affect the Growth and Lactic Acid Production by Vaginal Lactobacillus spp[J].Applied and Environmental Microbiology,2021,87(10):1-16.[14]Armstrong E,Hemmerling A,Miller S,et al.Metronidazole treatment rapidly reduces genital inflammation through effects on bacterial vaginosis-associated bacteria rather than lactobacilli[J].J Clin Invest,2022,132(6):e152930.[15]崔良慧,杨佳,张晓冉.完带汤联合甲硝唑凝胶治疗老年复发性细菌性阴道炎的疗效观察[J].老年医学与保健,2020,26(6):1077-1080.[16]李春霞,谢志虹,徐文艳,等.黄柏联合益生菌对妊娠37周后细菌性阴道炎孕妇不良妊娠结局的影响[J].河北医药,2019,41(10):1521-1524.[17]何静,白瑞.益生菌联合双唑泰泡腾片治疗细菌性阴道炎的疗效分析[J].医学临床研究,2022,39(2):222-224,228.[18]蓝丽萍,廖世雄,刘小慧.甲硝唑凝胶联合益生菌治疗孕早期细菌性阴道炎的疗效及对妊娠结局的影响[J].海南医学,2022,33(5):581-584.[19]霍墨杰,霍艳芬,苏俊泽.辅助应用乳酸菌阴道胶囊对阴道炎患者阴道微环境的调节作用分析[J].中国计划生育和妇产科,2018,10(7):14-17.[20]姚敏慧.益生菌临床治疗阴道炎的疗效与作用机制研究[J].中国药物与临床,2020,20(3):419-420.[21]范小琴,曾博洁,刘元春.戊酸雌二醇结合益生菌治疗产后阴道炎对阴道微生态及机体免疫功能的调节作用分析[J].中国性科学,2020,29(9):123-125.[22]Ross JDC,Brittain C,Anstey Watkins J,et al.Intravaginal lactic acid gel versus oral metronidazole for treating women with recurrent bacterial vaginosis: the VITA randomised controlled trial[J].BMC Womens Health,2023,23(1):241.[23]梁华,陈新敏,吴雨露.乳酸杆菌活菌制剂联合甲硝唑对细菌性阴道炎患者阴道微环境的影响[J].中国计划生育和妇产科,2018,10(2):76-78.

相似文献/References:

[1]崔艳婷.妇炎消胶囊联合硝呋太尔制霉素治疗 细菌性阴道炎的临床研究[J].医学信息,2019,32(11):154.[doi:10.3969/j.issn.1006-1959.2019.11.046]
　CUI Yan-ting.Clinical Study on Treatment of Bacterial Vaginitis with Fuyanxiao Capsule Combined with Nifuratel[J].Journal of Medical Information,2019,32(05):154.[doi:10.3969/j.issn.1006-1959.2019.11.046]

更新日期/Last Update: 1900-01-01