[1]杨 璨,田江红,李俊燕,等.血清AFP、GP73及PIVKA-Ⅱ检测对原发性肝癌的诊断效能[J].医学信息,2024,37(06):125-128,138.[doi:10.3969/j.issn.1006-1959.2024.06.021]
　YANG Can,TIAN Jiang-hong,LI Jun-yan,et al.Diagnostic Efficacy of Serum AFP, GP73 and PIVKA-Ⅱ in Primary Liver Cancer[J].Journal of Medical Information,2024,37(06):125-128,138.[doi:10.3969/j.issn.1006-1959.2024.06.021]
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血清AFP、GP73及PIVKA-Ⅱ检测对原发性肝癌的诊断效能()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年06期
页码:
125-128,138
栏目:
论著
出版日期:
2024-03-15

文章信息/Info

Title:
Diagnostic Efficacy of Serum AFP, GP73 and PIVKA-Ⅱ in Primary Liver Cancer
文章编号:
1006-1959（2024）06-0125-05
作者:
杨 璨; 田江红; 李俊燕; 等
（西安国际医学中心医院医学检验科，陕西 西安 710000）
Author(s):
YANG Can; TIAN Jiang-hong; LI Jun-yan; et al.
(Department of Medical Laboratory,Xi’an International Medical Center Hospital,Xi’an 710000,Shaanxi,China)
关键词:
甲胎蛋白; 高尔基体73; 异常凝血酶原; 原发性肝癌
Keywords:
Alpha-fetoprotein; Golgi apparatus 73; Abnormal prothrombin; Primary liver cancer
分类号:
R446.1
DOI:
10.3969/j.issn.1006-1959.2024.06.021
文献标志码:
A
摘要:
目的 研究血清甲胎蛋白（AFP）、高尔基体73（GP73）及异常凝血酶原（PIVKA-Ⅱ）单独及联合检测对原发性肝癌的诊断效能。方法 选取2021年1月-12月我院检验中心确诊的原发性肝癌患者132例作为原发性肝癌组，将肝炎、肝纤维化、肝硬化患者92例作为良性对照组，99名体检健康者作为健康对照组。采用磁微粒化学免疫发光法分析三组受试者血清AFP、GP73及PIVKA-Ⅱ水平，并比较各组差异。用受试者ROC工作曲线分析AFP、GP73及PIVKAⅡ对原发性肝癌的诊断价值。结果 原发性肝癌组血清AFP、GP73、PIVKA-Ⅱ水平均高于良性对照组和健康对照组（P＜0.05）；血清AFP、GP73、PIVKA-Ⅱ对原发性肝癌检测特异性分别为96.93%、70.72%、93.22%，敏感性分别为51.90%、81.51%、75.91%，AUC分别为0.77、0.80、0.88，血清PIVKA-Ⅱ具有高敏感性、特异性及AUC；三者联合诊断原发性肝癌的特异性为88.89%，敏感性为83.24%，AUC为0.90，均高于单一检测（P＜0.05）。结论 AFP、GP73、PIVKA-Ⅱ三者联合检测可提高原发性肝癌的检出率，降低漏诊率。
Abstract:
Objective To study the diagnostic efficacy of single and combined detection of serum alpha-fetoprotein (AFP), Golgi 73 (GP73) and abnormal prothrombin (PIVKA-Ⅱ) in primary liver cancer.Methods A total of 132 patients with primary liver cancer diagnosed in our hospital from January to December 2021 were selected as the primary liver cancer group, 92 patients with hepatitis, liver fibrosis and cirrhosis were selected as the benign control group, and 99 healthy subjects were selected as the healthy control group. The levels of serum AFP, GP73 and PIVKA-Ⅱ in the three groups were analyzed by magnetic particle chemical immunoluminescence method, and the differences between the groups were compared. The diagnostic value of AFP, GP73 and PIVKA-Ⅱ in primary liver cancer was analyzed by receiver operating characteristic (ROC) curve.Results The levels of serum AFP, GP73 and PIVKA-Ⅱ in primary liver cancer group were higher than those in benign control group and healthy control group (P<0.05). The specificity of serum AFP, GP73 and PIVKA-Ⅱ in the detection of primary liver cancer was 96.93%, 70.72% and 93.22%, respectively; the sensitivity was 51.90%, 81.51% and 75.91%, respectively; the AUC was 0.77, 0.80 and 0.88, respectively, thus serum PIVKA-Ⅱ had high sensitivity, specificity and AUC. The specificity, sensitivity and AUC of the combined diagnosis of primary liver cancer were 88.89%, 83.24% and 0.90, respectively, which were higher than those of single detection (P<0.05).Conclusion The combined detection of AFP, GP73 and PIVKA-Ⅱ can improve the detection rate of primary liver cancer and reduce the rate of missed diagnosis.

参考文献/References:

[1]Mohammadian M,Allah Bakeshei K,Mohammadian-Hafshejani A.International epidemiology of liver cancer: geographical distribu tion,secular trends and predicting the future[J].J Prev Med Hyg,2020,61:e259-e289.[2]Xie DY,Ren ZG,Zhou J,et al.2019 Chinese clinical guidelines for the management of hepatocellular carcinoma: updates and insights[J].Hepatobiliary Surg Nutr,2020,9(4):452-463.[3]Sarbarzeh PA,Karimi S,Jalilian M,et al.Depression,Anxiety,Stress and Social Isolation in Hepatitis Patients[J].SciMedicine J,2020,2(4):225-233.[4]Caviglia GP,Ribaldone DG,Abate ML,et al.Performance of protein induced by vitamin K absence or antagonist-II assessed by chemiluminescence enzyme immunoassay for hepatocellular carcinoma detection: a meta-analysis[J].Scand J Gastroenterol,2018,53(6):734-740.[5]Sartorius K,Sartorius B,Winkler C,et al.The biological and diagnostic role of miRNA’s in hepatocellular carcinoma[J].Front Biosci (Landmark Ed),2018,23(9):1701-1720.[6]Li C,Li R,Zhang W.Progress in non-invasive detection of liver fibrosis[J].Cancer Biol Med,2018,15(2):124-136.[7]关贵文,姚明解,钱相君,等.AFP和AFP-L3%联合检测在肝细胞癌诊断中的应用价值[J].临床肝胆病杂志,2019,35(7):1514-1518.[8]谢荣章,陈树华.联合血清AFP、TK1及DKK1水平检测对原发性肝癌诊断价值研究[J].国际检验医学杂志,2018,39(8):939-941,946.[9]Sai WL,Yao M,Shen SJ,et al.Dynamic expression of hepatic GP73 mRNA and protein and circulating GP73 during hepatocytes malignant transformation[J].Hepatobiliary Pancreat Dis Int,2020,19(5):449-454.[10]Liebman HA,Furie BC,Tong MJ,et al.Des-gamma-carboxy (abnormal) prothrombin as a serum marker of primary hepatocellular carcinoma[J].N Engl J Med,1984,310(22):1427-1431.[11]王姗,吴庆旺,李小科,等.《原发性肝癌诊疗规范（2019年版）》解读[J].临床肝胆病杂志,2020,36(5):996-999.[12]卢智略,李晓辉,王锦祥.围术期D-二聚体、抗凝血酶Ⅲ水平与肝癌肝部分切除术患者预后的相关性分析[J].中西医结合肝病杂志,2022,32(3):235-237[13]谭妮,郑海平,欧超.肝癌根治术治疗原发性肝癌患者的术后生存率及预后影响因素分析[J].现代肿瘤医学,2019,29(5):826-829.[14]Force M,Park G,Chalikonda D,et al.Alpha-Fetoprotein (AFP) and AFP-L3 Is Most Useful in Detection of Recurrence of Hepatocellular Carcinoma in Patients after Tumor Ablation and with Low AFP Level[J].Viruses,2022,14(4):775.[15]Galle PR,Foerster F,Kudo M,et al.Biology and significance of alpha-fetoprotein in hepatocellular carcinoma[J].Liver Int,2019,39(12):2214-2229.[16]Meng W,Bai B,Bai Z,et al.The immunosuppression role of alpha-fetoprotein in human hepatocellular carcinoma[J].Discov Med,2016,21(118):489-494.[17]Sauzay C,Petit A,Bourgeois AM,et al.Alpha-foetoprotein (AFP): A multi-purpose marker in hepatocellular carcinoma[J].Clin Chim Acta,2016,463:39-44.[18]Kladney RD,Bulla GA,Guo L,et al.GP73, a novel Golgi-localized protein upregulated by viral infection[J].Gene,2000,249(1-2):53-65.[19]刘智.AFP-L3、DCP及GP73在肝细胞肝癌临床应用中的价值[D].长春:吉林大学,2021.[20]孙景武,刘志春,张雷,等.原发性肝细胞癌与胆管细胞癌中高尔基体蛋白73及甲胎蛋白表达的临床意义[J].实用癌症杂志,2019,34(5):737-742.[21]王晓燕.联合检测血清GP73、AFP及AFP-L3在原发性肝癌中的诊断价值[J].标记免疫分析与临床,2017,24(1):64-66.[22]闫圆,李小全.血清高尔基体蛋白73联合AFP、AFU对诊断AFP 低水平原发性肝癌的价值分析[J].医学理论与实践,2022,35(17):2888-2890.[23]Mao Y,Yang H,Xu H,et al.Golgi protein 73 (GOLPH2) is a valuable serum marker for hepatocellular carcinoma[J].Gut,2010,59(12):1687-1693.[24]付超,齐军,李学祥,等.高尔基体蛋白 73( GP73) 检测在肝细胞癌中的应用价值[J].中国肿瘤,2010,19(8):553-556.[25]Liang R,Liu Z,Piao X,et al.Research progress on GP73 in malignant tumors[J].Onco Targets Ther,2018,11:7417-7421. [26]孙景武,刘志春,张雷,等.原发性肝细胞癌与胆管细胞癌中高尔基体蛋白73及甲胎蛋白表达的临床意义[J].实用癌症杂志,2019,34(5):737-742.[28]张珈玮.血清异常凝血酶原在肝细胞肝癌临床应用中的价值[D].长春:吉林大学,2019.[29]Kim MN,Kim BK,Kim SU,et al.Longitudinal assessment of alpha-fetoprotein for early detection of hepatocellular carcinoma in patients with cirrhosis[J].Scand J Gastroenterol,2019,54(10):1283-1290.

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更新日期/Last Update: 1900-01-01