[1]黄宇佳.阿莫西林克拉维酸钾治疗扁桃体炎的临床疗效及对PCT、TNF-α及IL-6水平的影响[J].医学信息,2024,37(10):137-140.[doi:10.3969/j.issn.1006-1959.2024.10.029]
　HUANG Yu-jia.Clinical Efficacy of Amoxicillin and Clavulanate Potassium in the Treatment of Tonsillitis and its Effect on the Levels of PCT, TNF-α and IL-6[J].Journal of Medical Information,2024,37(10):137-140.[doi:10.3969/j.issn.1006-1959.2024.10.029]
点击复制

阿莫西林克拉维酸钾治疗扁桃体炎的临床疗效及对PCT、TNF-α及IL-6水平的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年10期
页码:
137-140
栏目:
论著
出版日期:
2024-05-15

文章信息/Info

Title:
Clinical Efficacy of Amoxicillin and Clavulanate Potassium in the Treatment of Tonsillitis and its Effect on the Levels of PCT, TNF-α and IL-6
文章编号:
1006-1959（2024）10-0137-04
作者:
黄宇佳
（天津市第一中心医院药剂科，天津 300192）
Author(s):
HUANG Yu-jia
(Pharmacy Department of Tianjin First Central Hospital,Tianjin 300192,China)
关键词:
阿莫西林克拉维酸钾; 扁桃体炎; PCT; TNF-α; IL-6
Keywords:
Amoxicillin and clavulanate potassium; Tonsillitis; PCT; TNF-α; IL-6
分类号:
R766.18
DOI:
10.3969/j.issn.1006-1959.2024.10.029
文献标志码:
A
摘要:
目的 分析阿莫西林克拉维酸钾治疗扁桃体炎的临床疗效及对PCT、TNF-α及IL-6水平的影响。方法 选取2022年3月-2023年1月在我院诊治的56例扁桃体炎患者为研究对象，采用随机数字表法分为观察组和对照组，各组28例。对照组采用阿莫西林治疗，观察组采用阿莫西林克拉维酸钾治疗，比较两组临床疗效、症状消退时间、炎性因子水平[降钙素原（PCT）及白细胞介素-6（IL-6）水平、肿瘤坏死因子-α（TNF-α）]、不良反应发生率。结果 观察组治疗总有效率为92.86%，高于对照组的82.14%（P＜0.05）；观察组发热、扁桃体充血、咽喉疼痛、咽喉脓肿消退时间均短于对照组（P＜0.05）；两组治疗后PCT、IL-6、TNF-α均低于治疗前，且观察组低于对照组（P＜0.05）；观察组不良反应发生率为7.14%，低于对照组的21.43%（P＜0.05）。结论 阿莫西林克拉维酸钾治疗扁桃体炎具有良好的有效性和安全性，可提高临床疗效，降低不良反应发生率，促进炎症因子水平降低，快速减轻临床症状，对患者的康复具有积极的影响。
Abstract:
Objective To analyze the clinical efficacy of amoxicillin and clavulanate potassium in the treatment of tonsillitis and its effect on the levels of PCT, TNF-α and IL-6.Methods A total of 56 patients with tonsillitis diagnosed and treated in our hospital from March 2022 to January 2023 were selected as the research objects. They were divided into observation group and control group by random number table method, with 28 patients in each group. The control group was treated with amoxicillin, and the observation group was treated with amoxicillin and clavulanate potassium. The clinical efficacy, symptom regression time, inflammatory factor levels [procalcitonin (PCT) and interleukin-6 (IL-6) levels, tumor necrosis factor-α (TNF-α)] and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 92.86%, which was higher than 82.14% in the control group (P<0.05). The regression time of fever, tonsil congestion, sore throat and throat abscess in the observation group was shorter than that in the control group (P<0.05). After treatment, the levels of PCT, IL-6 and TNF-α in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group (P<0.05). The incidence of adverse reactions in the observation group was 7.14%, which was lower than 21.43% in the control group (P<0.05).Conclusion Amoxicillin and clavulanate potassium is effective and safe in the treatment of tonsillitis, which can improve the clinical efficacy, reduce the incidence of adverse reactions, promote the reduction of inflammatory factor levels. Meanwhile , it can quickly reduce clinical symptoms, and have a positive impact on the rehabilitation of patients.

参考文献/References:

[1]杨莹,沈彤,杨晓庆,等.血清C反应蛋白、降钙素原与急性化脓性扁桃体炎患儿阿莫西林克拉维酸钾治疗效果的相关性[J].中国耳鼻咽喉头颈外科,2021,28(12):784-785,787.[2]施林燕,顾晓慧.连花清瘟联合阿莫西林克拉维酸钾治疗小儿急性化脓性扁桃体炎的疗效[J].中国卫生标准管理,2021,12(22):117-120.[3]宋唤唤,马灵草,岳红.热毒宁注射液联合西医治疗对急性化脓性扁桃体炎患者炎症因子及免疫功能的影响[J].中西医结合研究,2020,12(3):149-153.[4]徐娟,徐祖龙,张亚明,等.热毒宁注射液佐治儿童急性化脓性扁桃体炎的疗效[J].江苏医药,2017,43(23):1747-1748.[5]刘艳,林绍琼,梁河.加味木贼宣痹汤治疗小儿急性化脓性扁桃体炎湿热证临床研究[J].四川中医,2019,37(2):93-95.[6]黄培练,潘艳东.疏风解毒胶囊联合头孢克洛干混悬剂治疗小儿扁桃体炎(风热证)临床观察[J].中国中医急症,2018,25(10):1984-1986.[7]余霞辉,舒红文,罗健,等.金双歧辅助治疗小儿扁桃体炎的临床研究[J].中国微生态学杂志,2018,28(2):169-173.[8]蔡茜,朱应群,陈思睿,等.喉咽清口服液联合阿莫西林克拉维酸钾注射液治疗成人急性化脓性扁桃体炎疗效观察[J].中国医药科学,2020,10(01):78-80.[9]张雯.雪胆素胶囊联合头孢丙烯治疗急性扁桃体炎的临床研究[J].现代药物与临床,2019,34(9):2627-2631.[10]Chen LE,Shen YZ,Jiang DY,et al.Amoxicillin and clavulanate potassium in treating children with suppurative tonsillitis[J].J Biol Regul Homeost Agents,2017,31(3):625-629.[11]赵义,黄旭,廖秋菊,等.柳氮磺吡啶致中性粒细胞缺乏症及急性化脓性扁桃体炎[J].药物不良反应杂志,2018,20(5):380-381.[12]马淑霞.喜炎平注射液联合阿奇霉素治疗小儿支原体肺炎的疗效及对血清细胞因子的影响[J].中草药,2019,50(12):2945-2949.[13]姚榕威,欧阳绍基,谢凤梅,等.慢性扁桃体炎患者手术治疗前后细胞免疫功能的变化[J].海南医学,2018,27(15):2533-2534.[14]古德凤.喜炎平联合干扰素治疗小儿轮状病毒肠炎的临床效果及对外周血中性粒细胞的影响[J].世界中西医结合杂志,2017,12(11):1590-1593.[15]Silva JHDAE,Almeida ECS,Sousa JC,et al.Tonsillar hyperplasia and recurrent acute tonsillitis in children: Immunohistochemical evaluation of the lymphatic tissue[J].Int J Pediatr Otorhinolaryngol,2019,121:15-19.[16]付海生,熊向菁,王青海.雾化吸入双黄连注射液对慢性扁桃体炎的疗效及IL-6、hs-CRP和TNF-α水平的影响[J].中华中医药学刊,2019,37(2):392-395.[17]陶丽.阿莫西林/克拉维酸钾治疗小儿化脓性扁桃体炎效果及安全性[J].中国医药科学,2021,11(6):97-99.[18]詹忠明,曹敏,汪红,等.降钙素原及白介素-6测定在急性扁桃体炎合并脓毒症患儿中的诊断价值分析[J].医学理论与实践,2019,32(2):268-270.[19]高莉莉.联合应用青霉素与地塞米松治疗急性化脓性扁桃体炎疗效分析[J].甘肃科技,2018,34(9):112-113.

相似文献/References:

[1]罗育新,李锐键,林 宇.超声刀扁桃体切除术后T细胞免疫功能情况评估[J].医学信息,2018,31(03):187.[doi:10.3969/j.issn.1006-1959.2018.03.071]
　LUO Yu-xin,LI Rui-jian,LIN Yu.Evaluation of Cellular Immune Function after Sonographic Scalpel Tonsillectomy[J].Journal of Medical Information,2018,31(10):187.[doi:10.3969/j.issn.1006-1959.2018.03.071]
[2]葛盘春.阿莫西林克拉维酸钾治疗儿童肺炎的临床疗效[J].医学信息,2022,35(06):135.[doi:10.3969/j.issn.1006-1959.2022.06.034]
　GE Pan-chun.Clinical Efficacy of Amoxicillin and Clavulanate Potassium in the Treatment of Pneumonia in Children[J].Journal of Medical Information,2022,35(10):135.[doi:10.3969/j.issn.1006-1959.2022.06.034]
[3]曾小兰.阿莫西林-克拉维酸钾、左氧氟沙星治疗下呼吸道感染的疗效及成本-效果分析[J].医学信息,2022,35(18):77.[doi:10.3969/j.issn.1006-1959.2022.18.019]
　ZENG Xiao-lan.Efficacy and Cost-effectiveness Analysis of Amoxicillin-clavulanate Potassium and Levofloxacin in Treatment of Lower Respiratory Tract Infection[J].Journal of Medical Information,2022,35(10):77.[doi:10.3969/j.issn.1006-1959.2022.18.019]
[4]蔡文斌.阿莫西林克拉维酸钾联合雾化吸入治疗小儿支气管肺炎的效果及对PCT、CRP的影响[J].医学信息,2022,35(19):68.[doi:10.3969/j.issn.1006-1959.2022.19.018]
　CAI Wen-bin.Effect of Amoxicillin and Clavulanate Potassium Combined with Aerosol Inhalation on Children with Bronchial Pneumonia and Its Influence on PCT and CRP[J].Journal of Medical Information,2022,35(10):68.[doi:10.3969/j.issn.1006-1959.2022.19.018]

更新日期/Last Update: 1900-01-01