[1]杨艳萍.基于网络药理和分子对接探讨二陈汤治疗慢性支气管炎的作用机制[J].医学信息,2024,37(13):7-12.[doi:10.3969/j.issn.1006-1959.2024.13.002]
 Mechanism of Erchen Decoction in the Treatment of Chronic Bronchitis Based on Network Pharmacology and Molecular Docking.Mechanism of Erchen Decoction in the Treatment of Chronic Bronchitis Based on Network Pharmacology and Molecular Docking[J].Journal of Medical Information,2024,37(13):7-12.[doi:10.3969/j.issn.1006-1959.2024.13.002]
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基于网络药理和分子对接探讨二陈汤治疗慢性支气管炎的作用机制()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年13期
页码:
7-12
栏目:
中医药信息
出版日期:
2024-07-01

文章信息/Info

Title:
Mechanism of Erchen Decoction in the Treatment of Chronic Bronchitis Based on Network Pharmacology and Molecular Docking
文章编号:
1006-1959(2024)13-0007-06
作者:
杨艳萍
(贵州省人民医院药剂科,贵州 贵阳 550002)
Author(s):
Mechanism of Erchen Decoction in the Treatment of Chronic Bronchitis Based on Network Pharmacology and Molecular Docking
(Department of Pharmacy,Guizhou Provincial People’s Hospital,Guiyang 550002,Guizhou,China)
关键词:
二陈汤慢性支气管炎网络药理学分子对接作用机制
Keywords:
Erchen decoctionChronic bronchitisNetwork pharmacologyMolecular dockingMechanism of action
分类号:
R259
DOI:
10.3969/j.issn.1006-1959.2024.13.002
文献标志码:
A
摘要:
目的 基于网络药理学和分子对接技术探讨二陈汤治疗慢性支气管炎(CB)的作用机制。方法 利用TCMSP数据库筛选出二陈汤的有效成分和所对应的靶点,GeneCards数据库获得CB相关靶点,Venn Diagram分析二陈汤和CB的共同靶点。运用Cytoscape_v3.8.0软件构建二陈汤复方调控网络。通过String平台进行蛋白互作网络(PPI)筛选关键靶点,利用Bioinformatics数据库对关键靶点进行生物过程及通路富集分析,并利用分子对接对关键靶点的可靠性进行评价。结果 二陈汤和CB的共同靶点有84个,有效成分有104种。二陈汤中槲皮素、山奈酚和黄芩素等有效成分,通过介导AKT1、IL1B等关键靶点,调节炎症信号通路从而治疗CB。分子对接表明,槲皮素-AKT1结合能为-8.4 kcal/mol,槲皮素-IL1B结合能为-7.4 kcal/mol,均有较好的亲和力。结论 二陈汤可通过有效成分槲皮素、山奈酚和黄芩素等调节AKT1、IL1B等关键靶点及下游炎症信号通路来减少炎症治疗CB。
Abstract:
Objective To explore the mechanism of Erchen decoction in the treatment of CB based on network pharmacology and molecular docking technology.Methods The effective components and corresponding targets of Erchen decoction were screened out by TCMSP database. GeneCards database was used to obtain CB-related targets, and Venn Diagram was used to analyze the common targets of Erchen decoction and CB. Cytoscape_v3.8.0 software was used to construct the regulatory network of Erchen decoction compound. The protein interaction network (PPI) was used to screen the key targets through the String platform. The Bioinformatics database was used to analyze the biological processes and pathway enrichment of the key targets, and the reliability of the key targets was evaluated by molecular docking.Results There were 84 common targets of Erchen decoction and CB, and 104 effective components. The effective components such as quercetin, kaempferol and baicalein in Erchen decoction regulate the inflammatory signaling pathway by mediating key targets such as AKT1 and IL1B to treat CB. Molecular docking showed that quercetin-AKT1 binding energy was-8.4 kcal/mol, and quercetin-IL1 B binding energy was-7.4 kcal/mol, both of which had good affinity.Conclusion Erchen decoction can reduce inflammation and treat CB by regulating key targets such as AKT1 and IL1B, and downstream inflammatory signaling pathways through effective components such as quercetin, kaempferol and baicalein.

参考文献/References:

[1]Lu LH,Long FY.Clinical effect of valsartan on chronic bronchitis complicated with hypertension[J].Med Hyg,2021,2021(3):609-613.[2]王强.盐酸氨溴索联合莫西沙星治疗慢性支气管炎的疗效观察[J].中国药物与临床,2018,18(9):1543-1544.[3]Zhang HT.Clinical observation on combination of Chinese and Western medicine in the treatment of acute attack of chronic bronchitis[J].J Pract Tradit Chin Med,2019,35(2):191-192.[4]You Y.Changes of serum tumor necrosis factor-α and interleukin-6 levels in elderly patients with chronic bronchitis at acute stage and its effect on prognosis[J].Chin J Gerontol,2014,34(3):680-681.[5]In RF.Clinical observation of Qingjin Huatan Decoction in treating acute attack of chronic bronchitis with Phlegm-Stagnation and Pulmonary Type[J].Chin Foreign Med Res,2019,17(8):31-32.[6]Bai YP,Li JS.Regular formulas of common syndromes of chronic bronchitis based on modern Chinese medicine experience[J].Chin J Gerontol,2019,39(15):3666-3671.[7]尚立芝,徐莉莉,吴珂,等.二陈汤对慢性支气管炎气道黏液高分泌的影响[J].中国老年学杂志,2018,38(8):1-3.[8]Deng L,Zhang X,Dong Y,et al.Erchen decoction combined with Sanziyangqin decoction for chronic obstructive pulmonary disease:A protocol for systematic review and meta analysis[J].Medicine,2020,99(40):e22315.[9]Guo H,Li Y,Qiu L,et al.Gua Lou Er Chen decoction attenuates atherosclerosis by reducing proteoglycans accumulation and inflammation[J].Phytomedicine,2023,115(2023):154801-154811.[10]Chen LP,Cai YM,Li JS.Medication rules of famous veteran traditional Chinese medicine doctor in treatment of chronic bronchitis based on implicit structure model[J].China J Chin Mater Med,2017,42(8):1609-1616.[11]Ru JL,Li P,Wang JN,et al.TCMSP: a data base of systems pharmacology for drugdiscovery from herbal medicines[J].J Cheminform,2014,6:13.[12]陈丽平,蔡永敏,李建生.基于隐结构模型的名老中医诊治慢性支气管炎用药规律探讨[J].中国中药杂志,2017,42(8):1609-1616.[13]Kim TH,Custodio RJ,Cheong JH,et al.Sleep Promoting Etftect ofLuteolin in Mice via Adenosine A1 and A2AReceptors[J].Biomol Ther (Seoul),2019,27(6):584-590.[14]汤喜兰,刘建勋,董伟,等.槲皮素对大鼠乳鼠心脏成纤维细胞炎症分泌的干预作用[J].中国中药杂志,2014,39(12):2314-2317.[15]Kim SH,Park JG,Lee J,et al.The Dietary Flavonoid Kaempferol Mediates Anti-Inflammatory Responses via the Src,Syk,IRAK1,and IRAK4 Molecular Targets[J].Mediators Inflamm,2015,2015:904142.[16]Zhao T,Tang H, Xie L,et al.Scutellaria baicalensis Georgi.(Lamiaceae):A review of its traditional uses,botany,phytochemistry,pharmacology and toxicology[J].J Pharm Pharmacol,2019,71(9):1353-1369.[17]陈艳,赵月,何楝楝,等.山萘酚对雨蛙素诱导小鼠急性胰腺炎的干预作用及机制[J].山东医药,2021,61(32):41-44.[18]Li L,Cui HR,Zhang Y,et al.Baicalin ameliorates multidrug-resistant Pseudomonas aeruginosa induced pulmonary inflammation in rat via arginine biosynthesis[J].Biomed Pharmacother,2023,162:114660.[19]宋兆莹.槲皮素对人膀胱癌细胞EJ的生物活性及其对STAT3信号通路的影响[D].大连:大连医科大学,2011.[20]谭鑫,鲜维,陈永锋,等.槲皮素治疗心力衰竭的分子机制:基于网络药理学与分子对接方法[J].南方医科大学学报,2021,41(8):1198-1206.[21]Liang B,Xiang Y,Zhang X,et al.Systematic Pharmacology and GEO Database Mining Revealed the Therapeutic Mechanism of Xuefu Zhuyu Decoration for Atherosclerosis Cardiovascular Disease[J].Front Cardiovasc Med,2020,7:592201.[22]Basner M,Rao HY,Goel N,et al.Sleep deprivation and neurobehavioral dynamics[J].Curr Opin Neurobiol,2013,23(5):854-863.[23]Souilhol C,Serbanovic-Canic J,Fragiadaki M,et al.Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes[J].Nat Rev Cardiol,2020,17(1):52-63.[24]Liu Y,Chen Q.Clinical study on Xiyanping injection combined with ceftriaxone sodium in treatment of children with bronchopneumonia[J].Drugs & Clinic,2017,32(4):686-689.[25]黄惠芬,范良,傅汝梅,等.玄参甘桔汤合三拗汤加减治疗燥热伤肺型感染后咳嗽的疗效观察[J].中国实验方剂学杂志,2019,25(3):125-130.

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更新日期/Last Update: 1900-01-01