Myeloperoxidase-related Diseases and its Detection Methods.Myeloperoxidase-related Diseases and its Detection Methods[J].Journal of Medical Information,2024,37(13):165-168.[doi:10.3969/j.issn.1006-1959.2024.13.036]





Myeloperoxidase-related Diseases and its Detection Methods
(延边大学化学生物学研究中心,吉林 延吉 133002)
Myeloperoxidase-related Diseases and its Detection Methods
(Research Centre of Chemical Biology,Yanbian University,Yanji 133002,Jilin,China)
MyeloperoxidaseMPO-related diseasesPathogenesisMPO activity detection
Myeloperoxidase (MPO) is a heme-rich peroxidase that catalyzes the formation of bactericidal oxidants and free radicals under the action of hydrogen peroxide (H2O2) and halides. Now MPO-derived chlorinated compounds have become biomarkers for the development of many diseases. Therefore, understanding the pathogenesis of MPO is helpful to develop inhibitors that are beneficial to the treatment of MPO, so as to reduce the negative effects of MPO-derived oxidants. This article mainly introduces the physiological role and nature of MPO, MPO-related diseases, and current methods for direct or indirect detection of MPO activity in vivo and in vitro. The aim is to provide more comprehensive information for MPO related research and disease diagnosis.


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更新日期/Last Update: 1900-01-01