[1]查芸璐,王小云,王 博,等.血脂代谢水平与痴呆分型因果关系的孟德尔随机化分析[J].医学信息,2026,39(01):40-44.[doi:10.3969/j.issn.1006-1959.2026.01.006]
 ZHA Yunlu,WANG Xiaoyun,WANG Bo,et al.Mendelian Randomization Analysis of the Causal Relationship BetweenBlood Lipid Metabolism Level and Dementia Classification[J].Journal of Medical Information,2026,39(01):40-44.[doi:10.3969/j.issn.1006-1959.2026.01.006]
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血脂代谢水平与痴呆分型因果关系的孟德尔随机化分析()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
39卷
期数:
2026年01期
页码:
40-44
栏目:
中医药信息学
出版日期:
2026-01-01

文章信息/Info

Title:
Mendelian Randomization Analysis of the Causal Relationship BetweenBlood Lipid Metabolism Level and Dementia Classification
文章编号:
1006-1959(2026)01-0040-05
作者:
查芸璐1王小云2王 博2吴慧敏1
1.湖北中医药大学第一临床学院,湖北 武汉 430065;2.湖北中医药大学附属武汉市中西医结合医院/武汉市第一医院康复医学科,湖北 武汉 430062
Author(s):
ZHA Yunlu1 WANG Xiaoyun2 WANG Bo2 WU Huimin1
1.The First Clinical College, Hubei University of Chinese Medicine, Wuhan 430065, Hubei, China;2.Department of Rehabilitation Medicine, Wuhan Hospital of Traditional Chinese and Western Medicine Affiliated to Hubei University of Chinese Medicine/Wuhan No.1 Hospital, Wuhan 430062, Hubei, China
关键词:
血脂痴呆全基因组关联研究孟德尔随机化单核苷酸多样性
Keywords:
Blood lipid Dementia Genome-wide association study Mendelian randomization Single nucleotide diversity
分类号:
R749.1+3
DOI:
10.3969/j.issn.1006-1959.2026.01.006
文献标志码:
A
摘要:
目的 采用两样本孟德尔随机化(MR)方法探究血脂代谢水平与痴呆的因果关系。方法 运用逆方差加权法(IVW)、加权中位数法、MR-Egger回归与加权模型开展MR分析,以OR值及95%CI评价常见血脂指标[总胆固醇(TC)、甘油三脂(TG)、载脂蛋白A(ApoA)、载脂蛋白B(ApoB)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)]与阿尔兹海默病痴呆(AD)、血管性痴呆(VAD)之间是否存在关联。结果 MR分析显示,LDL与AD具有正向的因果关系,OR=1.2460(95%CI:1.0367~1.4977,P=0.0191);其他血脂指标与AD、VAD间未发现相关关系(P>0.05)。结论 基于分析结果,LDL与AD存在正向的因果关系,LDL水平越高,患AD的风险越高,缺乏证据支持其他血脂指标与AD、VAD之间的因果关系。
Abstract:
Objective To explore the causal relationship between lipid metabolism and dementia by two-sample Mendelian randomization (MR) method. Methods MR analysis was performed using inverse variance weighting (IVW), weighted median method, MR-Egger regression and weighted model. OR value and 95%CI were used to evaluate whether there was a correlation between common blood lipid indexes [total cholesterol (TC), triglyceride (TG), apolipoprotein A (ApoA), apolipoprotein B (ApoB), low-density lipoprotein (LDL), high-density lipoprotein (HDL)] and Alzheimer′s disease dementia (AD) and vascular dementia (VAD). Results MR analysis showed that LDL had a positive causal relationship with AD, OR=1.2460 (95%CI: 1.0367-1.4977, P=0.0191). There was no correlation between other blood lipid indexes and AD and VAD (P>0.05). Conclusion Based on the analysis results, there is a positive causal relationship between LDL and AD. The higher the LDL level, the higher the risk of AD. There is no evidence to support the causal relationship between other blood lipid indexes and AD and VAD.

参考文献/References:

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更新日期/Last Update: 1900-01-01