[1]易 乖,易 赞.基于CiteSpace 的脑卒中缺血再灌注损伤神经炎症反应可视化分析[J].医学信息,2026,39(01):49-58.[doi:10.3969/j.issn.1006-1959.2026.01.008]
 YI Guai,YI Zan.Visual Analysis of Neuroinflammatory Response in Stroke Ischemia-reperfusionInjury Based on CiteSpace[J].Journal of Medical Information,2026,39(01):49-58.[doi:10.3969/j.issn.1006-1959.2026.01.008]
点击复制

基于CiteSpace 的脑卒中缺血再灌注损伤神经炎症反应可视化分析()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
39卷
期数:
2026年01期
页码:
49-58
栏目:
临床信息学
出版日期:
2026-01-01

文章信息/Info

Title:
Visual Analysis of Neuroinflammatory Response in Stroke Ischemia-reperfusionInjury Based on CiteSpace
文章编号:
1006-1959(2026)01-0049-10
作者:
易 乖1 易 赞2
株洲市三三一医院超声医学科1,神经疾病中心2,湖南 株洲 412000
Author(s):
YI Guai1 YI Zan2
Department of Ultrasonic Medicine1, Neurological Disease Center2, Zhuzhou 331 Hospital, Zhuzhou 412000, Hunan, China
关键词:
脑卒中缺血再灌注损伤神经炎症CiteSpace文献计量学
Keywords:
Stroke Ischemia-reperfusion injury Neuroinflammation CiteSpace Bibliometrics
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2026.01.008
文献标志码:
A
摘要:
目的 通过文献计量学分析,系统梳理脑卒中缺血再灌注损伤后神经炎症的研究现状,揭示该领域的研究热点、前沿动态及发展趋势,为后续研究提供参考和借鉴。方法 检索Web of Science核心合集(WoSCC)中2002年1月-2024年12月有关脑卒中缺血再灌注损伤后神经炎症的文献,采用CiteSpace 6.1.R6对其发文量、国家、作者、机构、引文和关键词进行可视化分析。结果 共纳入662篇相关文献,其年度发文量呈显著上升趋势。国家合作网络中,中国发文量最多(463篇),美国(0.87)和日本(0.74)的中心性较高;机构合作网络中,国内综合性大学和医科大学占据主导地位;作者合作网络中,形成了以Li Xing、Mao Meng等为核心的研究团队。共被引文献分析显示,神经炎症在脑卒中缺血/再灌注损伤及修复过程中的作用与机制受到广泛关注。关键词分析表明,氧化应激、激活、炎症反应等是研究热点,小胶质细胞/巨噬细胞、治疗策略等是未来研究趋势。结论 脑卒中缺血再灌注损伤后神经炎症的研究已取得一定成果,但仍需深入探讨其机制,以促进抗炎药物研发和临床转化,提升救治效率,改善患者预后。
Abstract:
Objective To systematically review the research status of neuroinflammation after stroke ischemia-reperfusion injury through bibliometric analysis, and to reveal the research hotspots, frontier trends and development trends in this field, so as to provide reference for subsequent research. Methods The literature on neuroinflammation after stroke ischemia-reperfusion injury in the Web of Science Core Collection (WoSCC) from January 2002 to December 2024 was retrieved. CiteSpace 6.1.R6 was used to visualize the number of publications, countries, authors, institutions, citations and keywords. Results A total of 662 related literatures were included, and the annual number of publications showed a significant upward trend. The results of the national cooperation network showed that China had the largest number of publications (463 literatures), and the centrality of the United States (0.87) and Japan (0.74) was higher. The results of institutional cooperation network showed that domestic comprehensive universities and medical universities dominate. The results of the author′s cooperation network showed that a research team with Li Xing, Mao Meng, etc. as the core had been formed. Co-cited literature analysis showed that the role and mechanism of neuroinflammation in stroke ischemia/reperfusion injury and repair process had been widely concerned. Keyword analysis showed that oxidative stress, activation and inflammatory response were research hotspots, and microglia/macrophages and treatment strategies were future research trends. Conclusion The research on neuroinflammation after stroke ischemia-reperfusion injury has achieved certain results, but its mechanism still needs to be further explored to promote the development and clinical translation of anti-inflammatory drugs, enhance treatment efficiency, and improve patient outcomes.

参考文献/References:

[1]Benjamin EJ,Muntner P,Alonso A,et al.Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association[J].Circulation,2019,139(10):e56-e528.[2]Lim S,Kim TJ,Kim YJ,et al.Senolytic Therapy for Cerebral Ischemia-Reperfusion Injury[J].Int J Mol Sci,2021,22(21):11967.[3]李馨蕊.TRPM2/CREB通路在缺血/再灌注导致神经元损伤中的作用及机制研究[D].上海:同济大学,2024.[4]吴致远.蜜二糖改善神经元自噬流减轻大鼠脑缺血/再灌注损伤的神经保护机制研究[D].昆明:昆明理工大学,2024.[5]Przykaza ?覵.Understanding the Connection Between Common Stroke Comorbidities, Their Associated Inflammation, and the Course of the Cerebral Ischemia/Reperfusion Cascade[J].Front Immunol,2021,12:782569.[6]王刚,仲婷婷,孙炎,等.免疫及炎性因子与急性缺血性卒中后神经损伤的相关性分析[J].临床急诊杂志,2022,23(2):91-94.[7]Chen CM.CiteSpace Ⅱ: Detecting and visualizing emerging trends and transient patterns in scientific literature[J]. Journal of The American Society for Information Science and Technology,2006,57(3):359-377.[8]Wang YL,He S,Liu XY,et al.Galectin-3 Mediated Inflammatory Response Contributes to Neurological Recovery by QiShenYiQi in Subacute Stroke Model[J].Front Pharmacol,2021,12:588587.[9]陈悦,陈超美,刘则渊,等.CiteSpace知识图谱的方法论功能[J].科学学研究,2015,33(2):242-253.[10]Kim DW,Lee TK,Ahn JH,et al.Porphyran Attenuates Neuronal Loss in the Hippocampal CA1 Subregion Induced by Ischemia and Reperfusion in Gerbils by Inhibiting NLRP3 Inflammasome-Mediated Neuroinflammation[J].Mar Drugs,2024,22(4):170.[11]Lee TK,Shin MC,Ha Park J,et al.Treatment with Risperidone Attenuates Oxidative Stress in the Kidney after Whole-Body Ischemia and Reperfusion Injury Induced by Cardiac Arrest in Rats[J].J Biol Regul Homeost Agents,2024,38(4):2795-2806.[12]Park JH,Lee TK,Kim DW,et al.Neuroprotective Effects of Aucubin against Cerebral Ischemia and Ischemia Injury through the Inhibition of the TLR4/NF-κB Inflammatory Signaling Pathway in Gerbils[J].Int J Mol Sci,2024,25(6):3461.[13]Xia Q,Que M,Zhan G,et al.SENP6-Mediated deSUMOylation of Nrf2 Exacerbates Neuronal Oxidative Stress Following Cerebral Ischemia and Reperfusion Injury[J].Adv Sci (Weinh),2025,12(7):e2410410.[14]Xia Q,Mao M,Zhan G,et al.SENP3-mediated deSUMOylation of c-Jun facilitates microglia-induced neuroinflammation after cerebral ischemia and reperfusion injury[J].iScience,2023,26(6):106953.[15]Xia Q,Zhan G,Mao M,et al.TRIM45 causes neuronal damage by aggravating microglia-mediated neuroinflammation upon cerebral ischemia and reperfusion injury[J].Exp Mol Med,2022,54(2):180-193.[16]Xia Q,Yu Y,Zhan G,et al.The Sirtuin 5 Inhibitor MC3482 Ameliorates Microglia-induced Neuroinflammation Following Ischaemic Stroke by Upregulating the Succinylation Level of Annexin-A1[J].J Neuroimmune Pharmacol,2024,19(1):17.[17]GBD 2019 STROKE COLLABORATORS.Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019[J].Lancet Neurol,2021,20(10):795-820.[18]Gong Z,Pan J,Shen Q,et al.Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia/reperfusion injury[J].J Neuroinflammation,2018,15(1):242.[19]Franke M,Bieber M,Kraft P,et al.The NLRP3 inflammasome drives inflammation in ischemia/reperfusion injury after transient middle cerebral artery occlusion in mice[J].Brain Behav Immun,2021,92:223-233.[20]Spangenberg E,Severson PL,Hohsfield LA,et al.Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model[J].Nat Commun,2019,10(1):3758.[21]Sokolina K,Kittanakom S,Snider J,et al.Systematic protein-protein interaction mapping for clinically relevant human GPCRs[J].Mol Syst Biol,2017,13(3):918.[22]Cheng ZF,Shao W,Wei CQ,et al.Cascade-Type Microglial Pyroptosis Inhibitors for Enhanced Treatment of Cerebral Ischemia-Reperfusion Injury[J].ACS Nano,2025,19(10):10529-10548.[23]Si WY,Yang CL,Wei SL,et al.Therapeutic potential of microglial SMEK1 in regulating H3K9 lactylation in cerebral ischemia-reperfusion[J].Communications Biology,2024,7(1):1701.[24]Dong ZF,Tang L,Zhang Y,et al.A Homing Peptide Modified Neutrophil Membrane Biomimetic Nanoparticles in Response to ROS/inflammatory Microenvironment for Precise Targeting Treatment of Ischemic Stroke[J].Adv Funct Mater,2024,34(4):1405-1426.[25]Chen S,Pan JR,Gong Z,et al.Hypochlorous acid derived from microglial myeloperoxidase could mediate high-mobility group box 1 release from neurons to amplify brain damage in cerebral ischemia-reperfusion injury[J].J Neuroinflammation,2024,21(1):70.[26]Xu BT,Qin YY,Li D,et al.Inhibition of PDE4 protects neurons against oxygen-glucose deprivation-induced endoplasmic reticulum stress through activation of the Nrf-2/HO-1 pathway[J].Redox Biology,2020,28:101342.[27]Tang L,Yin Y,Liu HN,et al.Blood-Brain Barrier-Penetrating and Lesion-Targeting Nanoplatforms Inspired by the Pathophysiological Features for Synergistic Ischemic Stroke Therapy[J].Adv Mater,2024,36(21):e2312897.[28]陈宏涛.小剂量秋水仙碱对急性脑梗死患者的疗效及炎症因子水平的影响[J].中国合理用药探索,2022,19(1):68-72.[29]Li J,Meng X,Shi FD,et al.Colchicine in patients with acute ischaemic stroke or transient ischaemic attack (CHANCE-3): multicentre, double blind, randomised, placebo controlled trial[J].BMJ,2024,385:e079061.[30]Zhao TK,He FJ,Zhao KQ,et al.A Triple-Targeted Rutin-Based Self-Assembled Delivery Vector for Treating Ischemic Stroke by Vascular Normalization and Anti-Inflammation via ACE2/Ang1-7 Signaling[J].ACS Central Science,2023,9(6):1180-1199.

相似文献/References:

[1]尹美丽.早期康复护理对脑卒中临床疗效及偏瘫肢体功能的影响分析[J].医学信息,2018,31(05):167.[doi:10.3969/j.issn.1006-1959.2018.05.061]
 YIN Mei-li.Effect of Early Rehabilitation Nursing on Clinical Effect of Stroke and Limb Function of Hemiplegia[J].Journal of Medical Information,2018,31(01):167.[doi:10.3969/j.issn.1006-1959.2018.05.061]
[2]杨立丹,吴 敬,王学军.调神益髓针刺法结合康复训练治疗脑卒中后 平衡功能障碍的临床分析[J].医学信息,2018,31(07):143.[doi:10.3969/j.issn.1006-1959.2018.07.049]
 YANG Li-dan,WU Jing,WANG Xue-jun.Clinical Analysis of Treatment of Balance Dysfunction after Stroke by Acupuncture of Regulating Spirit and Supplementing Pulp Combined with Rehabilitation Training[J].Journal of Medical Information,2018,31(01):143.[doi:10.3969/j.issn.1006-1959.2018.07.049]
[3]王晓强,张艳军,贾 琎,等.早期康复介入与脑卒中合并代谢综合征患者并发症的关系[J].医学信息,2018,31(08):96.[doi:10.3969/j.issn.1006-1959.2018.08.030]
 WANG Xiao-qiang,ZHANG Yan-jun,JIA Jin,et al.Relationship between Early Rehabilitation Intervention and Complications in Stroke Patients with Metabolic Syndrome[J].Journal of Medical Information,2018,31(01):96.[doi:10.3969/j.issn.1006-1959.2018.08.030]
[4]侯艳雁,王 杰,邓丛磊.重复经颅磁刺激联合步态适应性训练对脑卒中患者运动康复及生活质量的影响[J].医学信息,2022,35(09):157.[doi:10.3969/j.issn.1006-1959.2022.09.040]
 HOU Yan-yan,WANG Jie,DENG Cong-lei.Effects of Repetitive Transcranial Magnetic Stimulation Combined with Gait Adaptive Training on Motor Rehabilitation and Quality of Life in Patients with Stroke[J].Journal of Medical Information,2022,35(01):157.[doi:10.3969/j.issn.1006-1959.2022.09.040]
[5]李娅娜,曹 岚,徐 影,等.四肢联动联合虚拟现实训练对脑卒中恢复期患者 下肢功能与平衡功能的影响[J].医学信息,2018,31(14):107.[doi:10.3969/j.issn.1006-1959.2018.14.031]
 LI Ya-na,CAO Lan,XU Ying,et al.Effects of Limb Linkage and Virtual Reality Training on Lower Limb Function and Balance Function in Stroke Patients during Convalescence[J].Journal of Medical Information,2018,31(01):107.[doi:10.3969/j.issn.1006-1959.2018.14.031]
[6]邵俊丽.静息心率与脑卒中关系的研究[J].医学信息,2018,31(16):16.[doi:10.3969/j.issn.1006-1959.2018.16.006]
 SHAO Jun-li.Research on Relationship between Resting Heart Rate and Stroke[J].Journal of Medical Information,2018,31(01):16.[doi:10.3969/j.issn.1006-1959.2018.16.006]
[7]张怀祥,段晓宇.脑梗死后认知障碍的病理学机制、相关危险因素及治疗[J].医学信息,2018,31(16):21.[doi:10.3969/j.issn.1006-1959.2018.16.007]
 ZHANG Huai-xiang,DUAN Xiao-yu.Pathological Mechanism,Related Risk Factors and Treatment of Cognitive Impairment after Cerebral Infarction[J].Journal of Medical Information,2018,31(01):21.[doi:10.3969/j.issn.1006-1959.2018.16.007]
[8]平兴团,赵富强,杨 飞,等.家庭康复管理对卒中患者运动功能恢复的远期影响[J].医学信息,2018,31(16):66.[doi:10.3969/j.issn.1006-1959.2018.16.018]
 PING Xing-tuan,ZHAO Fu-qiang,YANG Fei,et al.Long-term Effects of Family Rehabilitation Management on Recovery of Motor Function in Stroke Patients[J].Journal of Medical Information,2018,31(01):66.[doi:10.3969/j.issn.1006-1959.2018.16.018]
[9]刘 萍,傅继红.30°斜坡式自动充气枕在鼻饲脑卒中 患者体位管理的可行性研究[J].医学信息,2018,31(17):170.[doi:10.3969/j.issn.1006-1959.2018.17.054]
 LIU Ping,FU Ji-hong.Feasibility Study on the Position Management of 30°Slope Automatic Inflatable Pillow in Patients with Nasal Feeding Stroke[J].Journal of Medical Information,2018,31(01):170.[doi:10.3969/j.issn.1006-1959.2018.17.054]
[10]马 超.大鼠背阔肌肌皮瓣缺血再灌注损伤局部缺血预处理及 肢体远程缺血预处理的影响对比[J].医学信息,2018,31(18):86.[doi:10.3969/j.issn.1006-1959.2018.18.026]
 MA Chao.Comparison of Effects of Ischemic Preconditioning and Remote Ischemic Preconditioning on Rat Latissimus Dorsi Musculocutaneous Flap Ischemia-reperfusion Injury[J].Journal of Medical Information,2018,31(01):86.[doi:10.3969/j.issn.1006-1959.2018.18.026]

更新日期/Last Update: 1900-01-01