[1]谢仁华,蒲 军,张威武,等.H型高血压与脑小血管疾病的相关性分析[J].医学信息,2026,39(01):84-89109.[doi:10.3969/j.issn.1006-1959.2026.01.014]
 XIE Renhua,PU Jun,ZHANG Weiwu,et al.Correlation Analysis of H-type Hypertension and Cerebral Small Vessel Disease[J].Journal of Medical Information,2026,39(01):84-89109.[doi:10.3969/j.issn.1006-1959.2026.01.014]
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H型高血压与脑小血管疾病的相关性分析()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
39卷
期数:
2026年01期
页码:
84-89109
栏目:
临床证据信息
出版日期:
2026-01-01

文章信息/Info

Title:
Correlation Analysis of H-type Hypertension and Cerebral Small Vessel Disease
文章编号:
1006-1959(2026)01-0084-07
作者:
谢仁华1蒲 军2张威武1王启敏1周 旋1李孝天1陈玉婷1
1.昭通市第一人民医院脑血管科,云南 昭通 657000;2.昆明医科大学第二附属医院神经外科一病区,云南 昆明 650100
Author(s):
XIE Renhua1 PU Jun2 ZHANG Weiwu1 WANG Qimin1 ZHOU Xuan1 LI Xiaotian1 CHEN Yuting1
1.Department of Cerebrovascular Disease, the First People′s Hospital of Zhaotong, Zhaotong 657000, Yunnan, China;2.The First Ward of Neurosurgery Department, the Second Affiliated Hospital of Kunming Medical University, Kunming 650100, Yunnan, China
关键词:
脑小血管病总体负担磁共振成像H型高血压同型半胱氨酸
Keywords:
Cerebral small vessel disease Total burden Magnetic resonance imaging H-type hypertension Homocysteine
分类号:
R544.1; R743.3
DOI:
10.3969/j.issn.1006-1959.2026.01.014
文献标志码:
A
摘要:
目的 探讨H型高血压与脑小血管疾病(CSVD)的相关性。方法 回顾性纳入2021年1月-2023年6月昭通市第一人民医院脑血管科急性缺血性脑卒中患者323例。根据是否合并高血压和高同型半胱氨酸分为4组:对照组(n=103)、单纯高同型半胱氨酸血症组(n=35)、H型高血压组(n=69)和单纯高血压组(n=116)。对CSVD总负担进行评级,探讨H型高血压与CSVD频谱的相关性,采用单因素分析及多因素Logistic回归分析探讨CSVD总负担的影响因素。结果 4组性别、年龄、吸烟、饮酒、收缩压、舒张压、糖尿病、甘油三酯、总胆固醇、低密度脂蛋白、血肌酐和同型半胱氨酸比较,差异有统计学意义(P<0.05);H型高血压与脑微出血(CMBs)、脑白质高强度(WMHs)、血管周围间隙扩大(ePVS)的严重程度有关(P<0.05);单因素分析结果显示,年龄、收缩压、舒张压、脑卒中病史、甘油三酯、低密度脂蛋白、单纯高同型半胱氨酸血症、H型高血压和单纯高血压是CSVD总负担的危险因素(P<0.05);多因素Logistic回归分析结果显示,年龄、收缩压、低密度脂蛋白、单纯高同型半胱氨酸血症、H型高血压和单纯高血压是CSVD总负担的独立危险因素(P<0.05)。结论 H型高血压与CSVD总负担和CSVD频谱有关,需要进一步采取预防措施。此外,高血压和高同型半胱氨酸血症对CSVD总负担有协同作用。
Abstract:
Objective To investigate the correlation between H-type hypertension and cerebral small vessel disease (CSVD). Methods A total of 323 patients with acute ischemic stroke in the Department of Cerebrovascular Disease, the First People′s Hospital of Zhaotong from January 2021 to June 2023 were retrospectively included. The patients were divided into 4 groups according to the presence or absence of hypertension and hyperhomocysteinemia: control group (n=103), simple hyperhomocysteinemia group (n=35), H-type hypertension group (n=69) and simple hypertension group (n=116). The total burden of CSVD was graded to explore the correlation between H-type hypertension and CSVD spectrum. Univariate analysis and multivariate logistic regression analysis were used to explore the influencing factors of the total burden of CSVD. Results There were significant differences in gender, age, smoking, drinking, systolic blood pressure, diastolic blood pressure, diabetes mellitus, triglyceride, total cholesterol, low density lipoprotein, serum creatinine and homocysteine among the four groups (P<0.05). H-type hypertension was related to the severity of cerebral microbleeds (CMBs), white matter hyperintense (WMHs) and enlarged perivascular spaces (ePVS) (P<0.05). Univariate analysis showed that age, systolic blood pressure, diastolic blood pressure, stroke history, triglyceride, low density lipoprotein, simple hyperhomocysteinemia, H-type hypertension and simple hypertension were risk factors for the total burden of CSVD (P<0.05). Multivariate logistic regression analysis showed that age, systolic blood pressure, low density lipoprotein, simple hyperhomocysteinemia, H-type hypertension and simple hypertension were independent risk factors for the total burden of CSVD (P<0.05). Conclusion H-type hypertension is related to the total burden of CSVD and the spectrum of CSVD, and further preventive measures are needed. In addition, hypertension and hyperhomocysteinemia have a synergistic effect on the total burden of CSVD.

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更新日期/Last Update: 1900-01-01