[1]代金山.早期肠内营养联合清胰承气汤对重症急性胰腺炎患者免疫功能、肠黏膜屏障的影响[J].医学信息,2026,39(01):100-104.[doi:10.3969/j.issn.1006-1959.2026.01.017]
　DAI Jinshan.Effect of Early Enteral Nutrition Combined with Qingyi Chengqi Decoction on Immune Functionand Intestinal Mucosal Barrier in Patients with Severe Acute Pancreatitis[J].Journal of Medical Information,2026,39(01):100-104.[doi:10.3969/j.issn.1006-1959.2026.01.017]
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早期肠内营养联合清胰承气汤对重症急性胰腺炎患者免疫功能、肠黏膜屏障的影响()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
39卷
期数:
2026年01期
页码:
100-104
栏目:
临床证据信息
出版日期:
2026-01-01

文章信息/Info

Title:
Effect of Early Enteral Nutrition Combined with Qingyi Chengqi Decoction on Immune Functionand Intestinal Mucosal Barrier in Patients with Severe Acute Pancreatitis
文章编号:
1006-1959（2026）01-0100-05
作者:
代金山
北京朝阳中西医结合急诊抢救医院急诊科，北京 100010
Author(s):
DAI Jinshan
Emergency Department, Beijing Chaoyang Integrative Medicine Rescue and First Aid Hospital, Beijing 100010, China
关键词:
早期肠内营养; 清胰承气汤; 重症急性胰腺炎; 免疫功能; 肠黏膜屏障
Keywords:
Early enteral nutrition;  Qingyi Chengqi decoction;  Severe acute pancreatitis;  Immune function;  Intestinal mucosal barrier
分类号:
R576
DOI:
10.3969/j.issn.1006-1959.2026.01.017
文献标志码:
A
摘要:
目的 探讨早期肠内营养联合清胰承气汤对重症急性胰腺炎患者免疫功能、肠黏膜屏障的影响。方法 选取2022年9月-2024年9月北京朝阳中西医结合急诊抢救医院收治的100例重症急性胰腺炎患者为研究对象，按照随机数字表法将其分为对照组和研究组，每组50例。对照组应用早期肠内营养治疗，研究组应用早期肠内营养联合清胰承气汤治疗。比较两组临床疗效、免疫功能[白细胞分化簇4（CD4+）、分化簇8（CD8+）、CD4+/CD8+、免疫球蛋白A（IgA）、免疫球蛋白G（IgG）、免疫球蛋白M（IgM）]、炎症因子水平[白细胞计数（WBC）、C反应蛋白（CRP）、降钙素原（PCT）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）]、肠黏膜屏障[内毒素、D-乳酸、二胺氧化酶、血清肠脂肪酸结合蛋白（IFABP）]。结果 研究组治疗总有效率为96.00%，高于对照组的74.00%（P＜0.05）；研究组治疗后免疫功能指标、炎症因子指标及肠黏膜屏障均优于对照组（P＜0.05）。结论 早期肠内营养联合清胰承气汤治疗重症急性胰腺炎患者的临床疗效确切，能够提高患者免疫功能，减轻炎症反应，改善肠黏膜屏障，值得临床应用。
Abstract:
Objective To investigate the effect of early enteral nutrition combined with Qingyi Chengqi decoction on immune function and intestinal mucosal barrier in patients with severe acute pancreatitis. Methods A total of 100 patients with severe acute pancreatitis admitted to Beijing Chaoyang Integrative Medicine Rescue and First Aid Hospital from September 2022 to September 2024 were selected as the research objects. According to the random number table method, they were divided into control group and study group, with 50 patients in each group. The control group was treated with early enteral nutrition, and the study group was treated with early enteral nutrition combined with Qingyi Chengqi decoction. The clinical efficacy, immune function [leukocyte cluster of differentiation 4 (CD4+), cluster of differentiation 8 (CD8+), CD4+/CD8+, immunoglobulin A (IgA), immunoglobulin G (IgG), immunoglobulin M (IgM)], inflammatory factor levels [white blood cell count (WBC), C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α)], intestinal mucosal barrier [endotoxin, D-lactic acid, diamine oxidase, serum intestinal fatty acid binding protein (IFABP)] were compared between the two groups. Results The total effective rate of treatment in the study group was 96.00%, which was higher than 74.00% in the control group (P<0.05). After treatment, the immune function indexes, inflammatory factor indexes and intestinal mucosal barrier of the study group were better than those of the control group (P<0.05). Conclusion Early enteral nutrition combined with Qingyi Chengqi decoction has a definite clinical effect in the treatment of patients with severe acute pancreatitis. It can improve the immune function of patients, reduce the inflammatory response and improve the intestinal mucosal barrier, which is worthy of clinical application.

参考文献/References:

[1]柴薪,张西京,方宗平.厚朴排气合剂联合早期肠内营养治疗重症急性胰腺炎的疗效观察[J].空军军医大学学报,2024,45(6):695-698.[2]诸小飞,傅恺,曹婷婷.奥曲肽联合早期肠内营养对老年重症急性胰腺炎患者肠黏膜屏障功能、肠道菌群和细胞因子的影响[J].中国老年学杂志,2022,42(3):588-590.[3]逄泽辉,王庆华.联合早期肠内营养和生态免疫肠内营养对重症急性胰腺炎大鼠肾功能保护作用[J].中国老年学杂志,2022,42(7):1718-1722.[4]艾晨阳,谭玉惠,李金亭.耳穴贴压对重症急性胰腺炎患者早期肠内营养喂养耐受性的临床研究[J].中国中西医结合外科杂志,2024,30(3):401-404.[5]曹洁,姚隆.早期肠内营养治疗对重症急性胰腺炎患者临床结局的影响[J].中国临床医生杂志,2021,49(9):1063-1066.[6]洪伟煊,王梅平,肖春红,等.合生元联合谷氨酰胺对重症急性胰腺炎病人行早期肠内营养耐受性及营养状况的影响[J].肠外与肠内营养,2022,29(2):85-88.[7]梁伟,曾志伟,周彩燕,等.超早期肠内营养联合前列地尔治疗重症急性胰腺炎的临床价值[J].中国临床医生杂志,2021,49(3):285-288.[8]何建伟,夏小丽,田巍巍,等.早期经鼻空肠管肠内营养支持联合益生菌对重症急性胰腺炎患者营养状况和肠道黏膜损伤程度的影响[J].临床与病理杂志,2020,40(11):2925-2931.[9]邓宝群,代高英.腹内压对重症急性胰腺炎病人早期肠内营养喂养不耐受的预测价值[J].护理研究,2020,34(8):1378-1382.[10]乔德峰,赵刘乐,刘海凤.柴芩承气汤配合奥曲肽对重症急性胰腺炎并发肠梗阻患者血清肿瘤坏死因子-α、白细胞介素-1β和C反应蛋白的影响[J].中国中医急症,2018,27(8):1362-1365.[11]黄秀芹,诸葛玮玮,孙学成,等.清胰化瘀汤保留灌肠配合早期肠内营养治疗重症急性胰腺炎的疗效观察[J].中国中医药科技,2022,29(5):795-797.[12]于亮亮,杨云琳.大黄附子汤联合早期肠内营养对重症急性胰腺炎大鼠肝损伤保护的实验研究[J].中国现代普通外科进展,2019,22(5):350-353.[13]甄春山.早期肠内营养应用于86例急性胰腺炎患者临床治疗的治疗情况观察[J].黑龙江医药,2017,30(4):910-911.[14]许文捷,朱培庭,钮宏文.早期肠内营养联合锦红汤对急性重症胰腺炎患者免疫功能影响[J].中国中西医结合外科杂志,2020,26(2):259-263.[15]唐莉,李丹丹.大承气汤联合清热通腑灌肠方治疗急性胰腺炎疗效研究[J].陕西中医,2023,44(3):333-336.[16]张何为,傅强,巩传勇,等.清肺承气汤对重症胰腺炎所致ARDS患者肺的局部免疫干预作用[J].中国中西医结合急救杂志,2022,29(1):49-52.[17]朱锋,瞿昌晶,陈慧丽,等.柴芩承气汤对重症急性胰腺炎并发肠梗阻患者免疫功能及血清血管活性肠肽胃动素胃泌素水平的影响[J].中国药物与临床,2022,22(2):165-168.[18]刘鸿雁,王敏,古玉兰.柴芩承气汤保留灌肠治疗腑实热结型急性胰腺炎疗效及对患者中医症候积分、血清淀粉酶的影响[J].陕西中医,2022,43(11):1551-1555.[19]黄梅,郑惠之,赵荣.大承气汤合大柴胡汤加芒硝外敷联合乌司他丁对重症急性胰腺炎患者腹内压及血清炎性因子的影响[J].中国中医急症,2018,27(11):2011-2014.[20]王克儒,王先安,陈丽春.清胰承气汤联合免疫肠内营养对重症急性胰腺炎患者肠黏膜屏障和细胞因子的影响[J].四川中医,2018,36(9):95-98.

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更新日期/Last Update: 1900-01-01