[1]廖荣琳.阿司匹林联合氯吡格雷双抗血小板治疗脑梗死患者的效果及对炎性因子水平、凝血功能的影响[J].医学信息,2026,39(01):105-109.[doi:10.3969/j.issn.1006-1959.2026.01.018]
　LIAO Ronglin.Effect of Aspirin Combined with Clopidogrel Dual Antiplatelet Therapy on Patients with Cerebral Infarction and its Effect on Inflammatory Factor Levels and Coagulation Function[J].Journal of Medical Information,2026,39(01):105-109.[doi:10.3969/j.issn.1006-1959.2026.01.018]
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阿司匹林联合氯吡格雷双抗血小板治疗脑梗死患者的效果及对炎性因子水平、凝血功能的影响()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
39卷
期数:
2026年01期
页码:
105-109
栏目:
临床证据信息
出版日期:
2026-01-01

文章信息/Info

Title:
Effect of Aspirin Combined with Clopidogrel Dual Antiplatelet Therapy on Patients with Cerebral Infarction and its Effect on Inflammatory Factor Levels and Coagulation Function
文章编号:
1006-1959（2026）01-0105-05
作者:
廖荣琳
广昌县人民医院内二科，江西 广昌 344900
Author(s):
LIAO Ronglin
The Second Department of Internal Medicine, Guangchang County People′s Hospital, Guangchang 344900, Jiangxi, China
关键词:
阿司匹林; 氯吡格雷; 双抗血小板治疗; 脑梗死; 炎性因子; 凝血功能
Keywords:
Aspirin;  Clopidogrel;  Dual antiplatelet therapy;  Cerebral infarction;  Inflammatory factor;  Coagulation function
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2026.01.018
文献标志码:
A
摘要:
目的 分析阿司匹林联合氯吡格雷双抗血小板治疗脑梗死患者的效果及对炎性因子水平、凝血功能的影响。方法 采用随机数字表法将2022年1月-2024年5月广昌县人民医院收治的60例脑梗死患者分为研究组和对照组，每组30例。对照组给予口服阿司匹林治疗，研究组在对照组治疗方案基础上予以硫酸氢氯吡格雷口服治疗。比较两组临床疗效、炎性因子水平[肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、白细胞介素-1β（IL-1β）、C反应蛋白（CRP）]、各量表评分（FMA评分、Barthel指数、NIHSS评分）、凝血功能[D-二聚体（D-D）、纤维蛋白原（FIB）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）]。结果 研究组治疗总有效率（96.67%）高于对照组（73.33%）（P＜0.05）；两组治疗后TNF-α、IL-1β、IL-6、CRP水平均低于治疗前，且研究组治疗后以上炎性因子水平均低于对照组（P＜0.05）；两组治疗后NIHSS评分均低于治疗前，而Barthel指数、上肢功能评分、下肢功能评分均高于治疗前，且研究组治疗后NIHSS评分低于对照组，而Barthel指数、上肢FMA评分、下肢FMA评分均高于对照组（P＜0.05）；两组治疗后D-D、FIB水平均低于治疗前，而APTT、PT水平均高于治疗前，且研究组治疗后D-D、FIB水平均低于对照组，而APTT、PT水平均高于对照组（P＜0.05）。结论 在脑梗死患者临床治疗中，阿司匹林联合氯吡格雷双抗血小板治疗可提升其临床疗效，对抑制炎症反应、改善神经功能和凝血功能、提高运动功能和日常生活活动能力方面具有积极作用。
Abstract:
Objective To analyze the effect of aspirin combined with clopidogrel dual antiplatelet therapy on patients with cerebral infarction and its effect on inflammatory factor levels and coagulation function. Methods In this study, 60 patients with cerebral infarction admitted to Guangchang County People′s Hospital between January 2022 and May 2024 were enrolled and underwent randomization into a study group and a control group using a random number table, each group had 30 patients. The control group was treated with aspirin orally, and the study group was treated with clopidogrel hydrogen sulfate orally on the basis of the treatment plan of the control group. The clinical efficacy, inflammatory factor levels [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), C-reactive protein (CRP)], scores of each scale (FMA score, Barthel index, NIHSS score), coagulation function [D-dimer (D-D), fibrinogen (FIB), prothrombin time (PT), activated partial thromboplastin time (APTT)] were compared between the two groups. Results The total effective rate of treatment in the study group (96.67%) was higher than that in the control group (73.33%) (P<0.05). After treatment, the levels of TNF-α, IL-1β, IL-6 and CRP in the two groups were lower than those before treatment, and the levels of the above inflammatory factors in the study group were lower than those in the control group (P<0.05). The NIHSS score of the two groups after treatment was lower than that before treatment, while the Barthel index, upper limb function score and lower limb function score were higher than those before treatment, and the NIHSS score of the study group after treatment was lower than that of the control group, while the Barthel index, upper limb FMA score and lower limb FMA score were higher than those of the control group (P<0.05). After treatment, the levels of D-D and FIB in the two groups were lower than those before treatment, while the levels of APTT and PT were higher than those before treatment, and the levels of D-D and FIB in the study group were lower than those in the control group, while the levels of APTT and PT were higher than those in the control group (P<0.05). Conclusion In the clinical treatment of patients with cerebral infarction, aspirin combined with clopidogrel dual antiplatelet therapy can improve its clinical efficacy, and has a positive effect on inhibiting inflammatory response, improving neurological function, coagulation function, motor function and activities of daily living.

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更新日期/Last Update: 1900-01-01