[1]徐小波.无创呼吸机联合氧气驱动雾化吸入治疗慢阻肺的临床效果及对患者肺功能指标的影响[J].医学信息,2026,39(01):114-118.[doi:10.3969/j.issn.1006-1959.2026.01.020]
　XU Xiaobo.Clinical Effect of Noninvasive Ventilator Combined with Oxygen-driven Atomizing Inhalationin the Treatment of Chronic Obstructive Pulmonary Diseaseand its Effect on Pulmonary Function Indexes[J].Journal of Medical Information,2026,39(01):114-118.[doi:10.3969/j.issn.1006-1959.2026.01.020]
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无创呼吸机联合氧气驱动雾化吸入治疗慢阻肺的临床效果及对患者肺功能指标的影响()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
39卷
期数:
2026年01期
页码:
114-118
栏目:
临床证据信息
出版日期:
2026-01-01

文章信息/Info

Title:
Clinical Effect of Noninvasive Ventilator Combined with Oxygen-driven Atomizing Inhalationin the Treatment of Chronic Obstructive Pulmonary Diseaseand its Effect on Pulmonary Function Indexes
文章编号:
1006-1959（2026）01-0114-05
作者:
徐小波
玉山县黄家驷医院/玉山县人民医院呼吸与危重症学科，江西 玉山 334700
Author(s):
XU Xiaobo
Department of Respiratory and Critical Care, Huangjiasi Hospital/Yushan County People′s Hospital, Yushan 334700, Jiangxi, China
关键词:
无创呼吸机; 氧气驱动雾化吸入; 慢阻肺; 肺功能
Keywords:
Noninvasive ventilator;  Oxygen-driven atomizing inhalation;  Chronic obstructive pulmonary disease;  Pulmonary function
分类号:
R563.4
DOI:
10.3969/j.issn.1006-1959.2026.01.020
文献标志码:
A
摘要:
目的 探讨无创呼吸机联合氧气驱动雾化吸入治疗慢阻肺的临床效果及对患者肺功能指标的影响。方法 选取2021年1月-2024年8月玉山县黄家驷医院/玉山县人民医院收治的慢阻肺患者64例为研究对象，根据随机数字表法分为对照组与研究组，各32例。对照组使用无创呼吸机治疗，研究组在对照组基础上使用氧气驱动进行雾化治疗。比较两组治疗效果、症状（咳嗽、呼吸困难、咳痰）缓解时间、肺功能[用力肺活量（FVC）、第1秒用力呼气容积（FEV1）、FEV1/FVC、肺总量（TLC）、残气量（RV）、RV/TLC、峰值呼气流速（PEF）]、动脉血气指标[心率（HR）、呼吸频率（RR）、血二氧化碳分压（PaCO2）、动脉血氧分压（PaO2）、血氧饱和度（SaO2）]。结果 研究组治疗总有效率高于对照组（P＜0.05）；研究组症状缓解时间均短于对照组（P＜0.05）；治疗后，研究组FEV1、FVC、FEV1/FVC、PEF水平均高于对照组，而TLC、RV、RV/TLC水平均低于对照组（P＜0.05）；研究组HR、RR、PaCO2水平均低于对照组，而PaO2、SaO2水平均高于对照组（P＜0.05）。结论 无创呼吸机联合氧气驱动雾化吸入治疗慢阻肺的临床效果确切，能够加快患者症状缓解，改善患者肺功能以及血气指标水平，值得临床应用。
Abstract:
Objective To investigate the clinical effect of noninvasive ventilator combined with oxygen-driven atomizing inhalation in the treatment of chronic obstructive pulmonary disease and its influence on pulmonary function indexes. Methods A total of 64 patients with chronic obstructive pulmonary disease admitted to Huangjiasi Hospital/Yushan County People′s Hospital from January 2021 to August 2024 were selected as the research objects. According to the random number table method, they were divided into control group and study group, with 32 patients in each group. The control group was treated with noninvasive ventilator, and the study group was treated with oxygen-driven atomizing inhalation on the basis of the control group. The therapeutic effect, remission time of symptoms (cough, dyspnea, expectoration), pulmonary function [forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FEV1/FVC, total lung capacity (TLC), residual volume (RV), RV/TLC, peak expiratory flow rate (PEF)], arterial blood gas indexes [heart rate (HR), respiratory rate (RR), partial pressure of carbon dioxide (PaCO2), partial pressure of oxygen (PaO2), oxygen saturation (SaO2)] were compared between the two groups. Results The total effective rate of treatment in the study group was higher than that in the control group (P<0.05). The symptom relief time of the study group was shorter than that of the control group (P<0.05). After treatment, the levels of FEV1, FVC, FEV1/FVC and PEF in the study group were higher than those in the control group, while the levels of TLC, RV and RV/TLC were lower than those in the control group (P<0.05). The levels of HR, RR and PaCO2 in the study group were lower than those in the control group, while the levels of PaO2 and SaO2 were higher than those in the control group (P<0.05). Conclusion Noninvasive ventilator combined with oxygen-driven atomizing inhalation has a definite clinical effect in the treatment of chronic obstructive pulmonary disease, which can accelerate the relief of symptoms and improve the pulmonary function and blood gas index of patients. It is worthy of clinical application.

参考文献/References:

[1]周艳华,郑颖妮.无创呼吸机联合氧气驱动雾化吸入治疗慢阻肺合并呼吸衰竭患者的临床效果及安全性观察[J].贵州医药,2021,45(3):376-378.[2]孟浩,杜永亮,赵杰,等.BiPAP呼吸机无创通气联合氧气驱动雾化吸入对慢阻肺合并呼吸衰竭的疗效[J].现代生物医学进展,2020,20(20):3915-3918.[3]杨燕,姚莉,万文霞,等.不同雾化吸入方法对慢性阻塞性肺疾病急性加重无创通气治疗的效果评价[J].中国呼吸与危重监护杂志,2023,22(9):615-623.[4]黄柳焕.慢阻肺急性加重期并Ⅱ型呼吸衰竭无创机械通气单日治疗时长的前瞻性研究[D].百色:右江民族医学院,2023.[5]张宁.无创呼吸机标准化治疗慢阻肺合并呼吸衰竭的价值分析[J].中国标准化,2023(14):239-242.[6]邓波,吴仕平,杨兴,等.无创呼吸机联合高流量氧疗治疗慢阻肺急性加重期合并呼吸衰竭患者疗效及对血清乳酸hs-CRP水平和血气指标的影响[J].河北医学,2022,28(11):1845-1850.[7]朱梦莉,张婧,曾琼莉,等.BiPAP无创呼吸机在急诊慢阻肺合并Ⅱ型呼吸衰竭的应用及护理[J].现代科学仪器,2020(3):106-108.[8]赵妍,蒋亚林,瞿香坤.无创呼吸机在慢阻肺急性加重并发Ⅱ型呼吸衰竭中的应用研究[J].临床肺科杂志,2022,27(11):1687-1691.[9]王永,刘亚玲,刘大凤,等.双水平气道正压无创呼吸机联合尼可刹米治疗急性加重期慢性阻塞性肺病合并Ⅱ型呼吸衰竭患者的临床疗效[J].实用医院临床杂志,2020,17(4):31-34.[10]卞锋全.经鼻高流量氧疗与无创呼吸机在老年慢性阻塞性肺疾病急性加重期合并Ⅱ型呼吸衰竭治疗中的应用效果[J].中国老年学杂志,2022,42(21):5223-5226.[11]孙丽娟,李珠.噻托溴铵联合无创呼吸机治疗慢阻肺并慢性呼吸衰竭的效果观察及对肺功能、T细胞免疫功能的影响[J].临床误诊误治,2020,33(10):31-35.[12]杨敏,王建华.噻托溴铵联合无创呼吸机治疗慢性阻塞性肺疾病急性加重合并Ⅱ型呼吸衰竭的疗效及安全性观察[J].贵州医药,2020,44(12):1933-1934.[13]胡慧芳,程炜炜,郭传辉.电子支气管镜辅助无创机械正压通气治疗老年慢阻肺合并呼吸衰竭的临床及疗效观察[J].中华保健医学杂志,2021,23(1):93-94,100.[14]王洪武,黄琳惠,蔡兴俊,等.有创-无创序贯机械通气治疗AECOPD合并Ⅱ型呼吸衰竭患者的临床疗效及影响因素[J].山东医药,2020,60(13):79-82.[15]王燕,张传名.氧气驱动雾化吸入联合体外振动排痰护理应用于慢阻肺急性期的效果评价[J].徐州医科大学学报,2018,38(6):412-415.[16]郭家瑶,刘燕秀.有创-无创序贯通气联合免疫肠内营养治疗慢阻肺合并Ⅱ型呼吸衰竭的研究[J].实用中西医结合临床,2023,23(3):52-55.[17]蔡国玲,李欣,陈莹莹.慢性阻塞性肺疾病合并呼吸衰竭患者行不同序贯通气转换标准下机械通气的效果[J].临床医学,2024,44(6):49-51.[18]常瑞.有创呼吸机无创呼吸机序贯治疗重症慢性阻塞性肺疾病Ⅱ型呼吸衰竭的临床疗效评价[J].山西医药杂志,2021,50(9):1460-1462.[19]王润丰,王瑛,徐婷,等.Narcotrend指导下右美托咪定在老年慢性阻塞性肺疾病急性加重并发呼吸衰竭患者无创通气中的应用[J].临床肺科杂志,2023,28(2):183-188.[20]粟玲,沈瑶,杨叶梦,等.无创机械通气串联雾化吸入治疗老年慢性阻塞性肺疾病急性加重期合并Ⅱ型呼吸衰竭的临床观察[J].老年医学与保健,2020,26(2):245-249.

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更新日期/Last Update: 1900-01-01