[1]张阳慧.不同高压氧治疗时间窗对脑梗死患者脑能量代谢及血流动力学的影响[J].医学信息,2026,39(01):119-122.[doi:10.3969/j.issn.1006-1959.2026.01.021]
　ZHANG Yanghui.Effects of Different Time Windows of Hyperbaric Oxygen Therapy on Brain Energy Metabolismand Hemodynamics in Patients with Cerebral Infarction[J].Journal of Medical Information,2026,39(01):119-122.[doi:10.3969/j.issn.1006-1959.2026.01.021]
点击复制

不同高压氧治疗时间窗对脑梗死患者脑能量代谢及血流动力学的影响()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
39卷
期数:
2026年01期
页码:
119-122
栏目:
临床证据信息
出版日期:
2026-01-01

文章信息/Info

Title:
Effects of Different Time Windows of Hyperbaric Oxygen Therapy on Brain Energy Metabolismand Hemodynamics in Patients with Cerebral Infarction
文章编号:
1006-1959（2026）01-0119-04
作者:
张阳慧
天津北大医疗海洋石油医院神经内科，天津 300452
Author(s):
ZHANG Yanghui
Department of Neurology, Tianjin PKUCare CNOOC Hospital, Tianjin 300452, China
关键词:
高压氧; 时间窗; 脑梗死; 脑能量代谢; 血流动力学
Keywords:
Hyperbaric oxygen;  Time window;  Cerebral infarction;  Brain energy metabolism;  Hemodynamics
分类号:
R743.33
DOI:
10.3969/j.issn.1006-1959.2026.01.021
文献标志码:
A
摘要:
目的 探讨不同高压氧治疗时间窗对脑梗死患者脑能量代谢及血流动力学的影响。方法 选取2021年6月-2024年5月天津北大医疗海洋石油医院收治的80例脑梗死患者作为研究对象，按照随机数字表法将其分为对照组和研究组，每组40例。研究组于发病12 h内施以高压氧治疗。对照组于发病3 d内施以高压氧治疗。比较两组治疗有效率、肢体功能、脑能量代谢水平（血糖、乳酸、血氧饱和度）、脑血流动力学指标[双侧大脑中动脉收缩期峰值速度（PSV）、舒张末期速度（EDV）、平均血流速度（Vm）及搏动指数（PI）]。结果 研究组治疗总有效率高于对照组（P＜0.05）。治疗后，研究组肢体功能优于对照组（P＜0.05）。研究组血糖、乳酸水平均低于对照组，而血氧饱和度高于对照组（P＜0.05）。研究组PSV、EDV、Vm水平均高于对照组，而PI水平均低于对照组（P＜0.05）。结论 发病12 h内施以高压氧治疗在脑梗死患者中的应用效果确切，能够改善患者肢体功能以及脑能量代谢水平，提高患者脑血流速度。
Abstract:
Objective To investigate the effects of different time windows of hyperbaric oxygen therapy on brain energy metabolism and hemodynamics in patients with cerebral infarction. Methods From June 2021 to May 2024, 80 patients with cerebral infarction admitted to Tianjin PKUCare CNOOC Hospital were selected as the research objects. Using the random number table method, the patients were assigned to control group and study group, with 40 patients in each group. The study group was treated with hyperbaric oxygen within 12 h of onset. The control group was treated with hyperbaric oxygen within 3 days of onset. The effective rate of treatment, limb function, brain energy metabolism level (blood glucose, lactic acid, blood oxygen saturation), cerebral hemodynamic indexes [bilateral middle cerebral artery peak systolic velocity (PSV), end diastolic velocity (EDV), mean blood flow velocity (Vm) and pulsatility index (PI)] were compared between the two groups. Results The total effective rate of treatment in the study group was higher than that in the control group (P<0.05). After treatment, the limb function of the study group was better than that of the control group (P<0.05). The levels of blood glucose and lactic acid in the study group were lower than those in the control group, while the oxygen saturation was higher than that in the control group (P<0.05). The levels of PSV, EDV and Vm in the study group were higher than those in the control group, while the level of PI were lower than that in the control group (P<0.05). Conclusion The application of hyperbaric oxygen therapy within 12 h of onset in patients with cerebral infarction is effective, which can improve their limb function and brain energy metabolism level, as well as improve the cerebral blood flow velocity.

参考文献/References:

[1]杨晓丽,曹建.多导睡眠监测仪分析不同阶段高压氧对急性脑梗死后睡眠障碍的治疗效果[J].贵州医科大学学报,2024,49(6):925-930.[2]韩娟,钟莲梅,雷春艳,等.不同时间窗高压氧治疗对急性脑梗死患者颈动脉血流动力学及血清Hcy、sICAM-1、IL-1β水平的影响[J].脑与神经疾病杂志,2024,32(9):576-580.[3]梁慧.高压氧介入时间对ACI患者神经功能缺损、血清VEGF、Ang-2、NSE水平的影响[J].医药论坛杂志,2019,40(4):113-115.[4]赵波,张斌.高压氧对急性缺血性脑卒中患者血清TNF-α、ET及NPY的影响[J].西北国防医学杂志,2018,39(6):370-374.[5]段雪梅,卢明,张娟,等.不同疗程高压氧治疗对急性脑梗死患者神经功能恢复及相关炎症因子的影响[J].保健医学研究与实践,2023,20(3):61-64.[6]刘洁,王泳,刘素娟,等.高压氧联合前列地尔注射液对颅内动脉瘤夹闭术后患者脑灌注、神经功能的影响以及对脑梗死的预防作用[J].中国医刊,2023,58(4):435-439.[7]解益宁,姜素兰,张晶晶.介入溶栓联合高压氧对急性闭塞性脑梗死患者NHISS评分和生活质量的影响[J].中风与神经疾病杂志,2022,39(11):982-985.[8]李素丹,赖东建,李亮雄,等.通元针法联合高压氧治疗脑梗死昏迷的疗效及对患者脑电图和血液流变学指标的影响[J].中国老年学杂志,2023,43(15):3613-3616.[9]王梅,叶玲,韩肖晓.高压氧联合rTMS改善脑梗死后认知功能障碍患者神经功能及认知功能的效果观察[J].临床和实验医学杂志,2023,22(9):972-975.[10]李娜,王圣元,孟祥恩.高压氧联合丁苯酞对急性脑梗死患者神经功能及血清Ang-1THBS-1和Bcl-2水平的影响[J].河北医学,2023,29(12):2011-2016.[11]王国堰,崔芝红.四藤通脉汤配合高压氧治疗颅内动脉瘤栓塞术后脑血管痉挛疗效及对患者大脑中动脉血流速度和神经功能的影响[J].现代中西医结合杂志,2018,27(28):3147-3150.[12]任鲜卉,李敏,刘丽娟,等.不同时间窗高压氧治疗对急性脑梗死患者血清ZO-1、Caveolin-1和TLR4/NF-κB信号通路的影响[J].现代生物医学进展,2024,24(6):1082-1085,1104.[13]郝苗清,孔立.补阳还五汤联合高压氧对急性脑梗死患者血液流变学的影响及疗效[J].武汉大学学报（医学版）,2019,40(3):484-487.[14]车永红.高压氧联合依折麦布对肥胖急性脑梗死患者神经功能及血清相关指标的影响[J].中国药物与临床,2020,20(23):3987-3989.[15]许迎春,丁晶,田珍,等.头皮针联合高压氧治疗对急性脑梗死患者功能恢复及血清同型半胱氨酸、超敏C反应蛋白的影响[J].中华物理医学与康复杂志,2021,43(11):996-1000.[16]齐飞,苏延玲,张慧.高压氧联合重复经颅磁刺激治疗脑梗死后认知功能障碍患者的疗效及对血流动力学的影响[J].中华航海医学与高气压医学杂志,2021,28(3):383-388.[17]都丽丽,于群涛,王英,等.不同疗程高压氧治疗对急性脑梗死患者颈动脉粥样硬化易损斑块及相关炎性因子的影响[J].中华航海医学与高气压医学杂志,2021,28(6):732-737.[18]刘丽,牛亚妹,张世平.高压氧的治疗时机对急性脑梗死伴糖尿病患者的疗效及对其簇集蛋白、抵抗素及可溶性细胞间黏附分子-1等指标的影响分析[J].中国急救复苏与灾害医学杂志,2021,16(5):529-532.[19]邵帅,滕跃华,王倩.高压氧治疗对急性脑梗死患者神经功能恢复及血清VEGF、Ang-2、NSE水平的影响[J].中国医师杂志,2022,24(3):436-439.

相似文献/References:

[1]蒋娜娜,王文学,郑 伟,等.创伤性脊髓损伤康复治疗最佳介入时间窗观察[J].医学信息,2018,31(07):85.[doi:10.3969/j.issn.1006-1959.2018.07.027]
　JIANG Na-na,WANG Wen-xue,ZHENG Wei,et al.Observation on the Best Interventional Time Window for Rehabilitation of Traumatic Spinal Cord Injury[J].Journal of Medical Information,2018,31(01):85.[doi:10.3969/j.issn.1006-1959.2018.07.027]
[2]陆 晚,黄宗国,廖 胜,等.高压氧治疗胸段脊髓损伤的临床分析[J].医学信息,2018,31(10):84.[doi:10.3969/j.issn.1006-1959.2018.10.025]
　LU Wan,HUANG Zong-guo,LIAO Sheng,et al.Clinical Analysis of Hyperbaric Oxygen Therapy for Thoracic Spinal Injury[J].Journal of Medical Information,2018,31(01):84.[doi:10.3969/j.issn.1006-1959.2018.10.025]
[3]李晓兴,王学军,吴继伟,等.补阳还五汤联合高压氧治疗脑外伤后综合征的疗效观察[J].医学信息,2018,31(23):145.[doi:10.3969/j.issn.1006-1959.2018.23.042]
　LI Xiao-xing,WANG Xue-jun,WU Ji-wei,et al.Efficacy of BuyangHuanwu Decoction Combined with Hyperbaric Oxygen in Treating Post Traumatic Brain Syndrome[J].Journal of Medical Information,2018,31(01):145.[doi:10.3969/j.issn.1006-1959.2018.23.042]
[4]王 璇.高压氧综合治疗脑卒中并发吞咽障碍的疗效[J].医学信息,2019,32(15):92.[doi:10.3969/j.issn.1006-1959.2019.15.028]
　WANG Xuan.Therapeutic Effect of Hyperbaric Oxygen Therapy on Cerebral Stroke Complicated with Dysphagia[J].Journal of Medical Information,2019,32(01):92.[doi:10.3969/j.issn.1006-1959.2019.15.028]
[5]李 燕,杨 柳,朱诗苗.有氧运动联合高压氧治疗脑卒中后认知功能障碍的疗效及对氧化应激的影响[J].医学信息,2022,35(17):114.[doi:10.3969/j.issn.1006-1959.2022.17.030]
　LI Yan,YANG Liu,ZHU Shi-miao.Effect of Aerobic Exercise Combined with Hyperbaric Oxygen on Cognitive Dysfunction After Stroke and its Effect on Oxidative Stress[J].Journal of Medical Information,2022,35(01):114.[doi:10.3969/j.issn.1006-1959.2022.17.030]
[6]袁秀萍.高压氧联合尼莫地平治疗脑小血管病所致 认知功能障碍的疗效评价[J].医学信息,2019,32(17):79.[doi:10.3969/j.issn.1006-1959.2019.17.024]
　YUAN Xiu-ping.Efficacy Evaluation of Hyperbaric Oxygen Combined with Nimodipine in the Treatment of Cognitive Dysfunction Caused by Cerebral Small Vessel Disease[J].Journal of Medical Information,2019,32(01):79.[doi:10.3969/j.issn.1006-1959.2019.17.024]
[7]袁 鹏.HBO联合Valpar职业评估训练对脑外伤后认知功能障碍患者的影响[J].医学信息,2020,33(18):89.[doi:10.3969/j.issn.1006-1959.2020.18.028]
　YUAN Peng.The Effect of HBO Combined with Valpar Occupational Assessment Training on Patients with Cognitive Dysfunction After Brain Injury[J].Journal of Medical Information,2020,33(01):89.[doi:10.3969/j.issn.1006-1959.2020.18.028]
[8]王 瑶.高压氧辅助治疗脑动脉硬化症患者的疗效[J].医学信息,2021,34(06):139.[doi:10.3969/j.issn.1006-1959.2021.06.036]
　WANG Yao.Efficacy of Hyperbaric Oxygen in the Treatment of Cerebral Arteriosclerosis Patients[J].Journal of Medical Information,2021,34(01):139.[doi:10.3969/j.issn.1006-1959.2021.06.036]
[9]袁 鹏,杜 斌,刘 锌,等.高压氧治疗股骨头坏死短期疗效的Meta分析[J].医学信息,2021,34(12):87.[doi:10.3969/j.issn.1006-1959.2021.12.023]
　YUAN Peng,DU Bin,LIU Xin,et al.Meta-analysis of the Short-term Curative Effect of Hyperbaric Oxygen in the Treatment of Femoral Head Necrosis[J].Journal of Medical Information,2021,34(01):87.[doi:10.3969/j.issn.1006-1959.2021.12.023]
[10]吕艳丽.联合高压氧治疗在创面修复中的应用研究[J].医学信息,2021,34(14):32.[doi:10.3969/j.issn.1006-1959.2021.14.009]
　LYU Yan-li.Study on the Application of Combined Hyperbaric Oxygen Therapy in Wound Healing[J].Journal of Medical Information,2021,34(01):32.[doi:10.3969/j.issn.1006-1959.2021.14.009]

更新日期/Last Update: 1900-01-01