[1]刘丽霞,李玉琳.寿胎丸加减联合黄体酮治疗肾虚型先兆流产的疗效及对血清HCG水平的影响[J].医学信息,2026,39(01):123-126.[doi:10.3969/j.issn.1006-1959.2026.01.022]
　LIU Lixia,LI Yulin.Curative Effect of Modified Shoutai Pills Combined with Progesterone in the Treatment of Threatened Abortion of Kidney Deficiency Type and its Effect on Serum HCG Level[J].Journal of Medical Information,2026,39(01):123-126.[doi:10.3969/j.issn.1006-1959.2026.01.022]
点击复制

寿胎丸加减联合黄体酮治疗肾虚型先兆流产的疗效及对血清HCG水平的影响()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
39卷
期数:
2026年01期
页码:
123-126
栏目:
临床证据信息
出版日期:
2026-01-01

文章信息/Info

Title:
Curative Effect of Modified Shoutai Pills Combined with Progesterone in the Treatment of Threatened Abortion of Kidney Deficiency Type and its Effect on Serum HCG Level
文章编号:
1006-1959（2026）01-0123-04
作者:
刘丽霞; 李玉琳
广昌县人民医院妇产科，江西 广昌 344900
Author(s):
LIU Lixia;  LI Yulin
Department of Obstetrics and Gynecology, Guangchang County People′s Hospital, Guangchang 344900, Jiangxi, China
关键词:
肾虚型先兆流产; 寿胎丸; 黄体酮; 人绒毛膜促性腺激素; 早产
Keywords:
Threatened abortion of kidney deficiency type;  Shoutai pills;  Progesterone;  Human chorionic gonadotropin;  Premature birth
分类号:
R714.21
DOI:
10.3969/j.issn.1006-1959.2026.01.022
文献标志码:
A
摘要:
目的 探究肾虚型先兆流产（TA）应用寿胎丸加减联合黄体酮治疗的效果。方法 以随机数字表法将2021年7月-2024年7月广昌县人民医院妇产科治疗的60例肾虚型TA患者进行分组对照研究，分为对照组（30例）与观察组（30例）。对照组给予黄体酮治疗，观察组应用寿胎丸加减联合黄体酮治疗，比较两组临床疗效、中医症状积分、人绒毛膜促性腺激素（HCG）、孕酮（P）、不良反应、妊娠结局（早产、胎膜早破、产后出血）。结果 观察组保胎成功率（96.67%）高于对照组（80.00%）（P＜0.05）；两组治疗后中医症状积分（阴道出血、下腹坠痛、腰膝酸软）低于治疗前，且观察组以上中医症状积分低于对照组（P＜0.05）；两组治疗后HCG、P指标高于治疗前，且观察组HCG、P指标高于对照组（P＜0.05）；观察组不良反应发生率与对照组比较，差异无统计学意义（P＞0.05）；观察组早产发生率低于对照组（P＜0.05），而两组胎膜早破、产后出血发生率比较，差异无统计学意义（P＞0.05）。结论 寿胎丸加减联合黄体酮治疗肾虚型TA效果确切，可提高患者保胎成功率，缓解其中医症状，对患者HCG、P水平具有良好调节作用，有助于降低早产风险，安全性佳。
Abstract:
Objective To explore the effect of modified Shoutai pills combined with progesterone in the treatment of threatened abortion (TA) with kidney deficiency type. Methods In this controlled study, 60 TA patients with kidney deficiency type from the Department of Obstetrics and Gynecology, Guangchang County People′s Hospital (July 2021 to July 2024) were randomized using a random number table into two groups: a control group (n=30) and an observation group (n=30). The control group was treated with progesterone, and the observation group was treated with modified Shoutai pills combined with progesterone. The clinical efficacy, TCM symptom score, human chorionic gonadotropin (HCG), progesterone (P), adverse reactions and pregnancy outcomes (premature delivery, premature rupture of membranes, postpartum hemorrhage) were compared between the two groups. Results The success rate of miscarriage in the observation group (96.67%) was higher than that in the control group (80.00%) (P<0.05). After treatment, the scores of TCM symptoms (vaginal bleeding, lower abdominal pain, lumbar debility) in the two groups were lower than those before treatment, and the scores of TCM symptoms in the observation group were lower than those in the control group (P<0.05). The HCG and P indexes of the two groups after treatment were higher than those before treatment, and the HCG and P indexes of the observation group were higher than those of the control group (P<0.05). No significant difference was observed in the incidence of adverse reactions between the observation group and the control group (P>0.05). The incidence of preterm birth in the observation group was lower than that in the control group (P<0.05), but no significant difference was observed in the incidence of premature rupture of membranes and postpartum hemorrhage between the two groups (P>0.05). Conclusion Modified Shoutai pills combined with progesterone is effective in the treatment of TA with kidney deficiency, which can improve the success rate of fetal protection, relieve the symptoms of traditional Chinese medicine, and has a good regulatory effect on the levels of HCG and P. Meanwhile, it is helpful to reduce the risk of premature delivery and has good safety.

参考文献/References:

[1]张燕,邵岚,范红芳,等.寿胎丸加减治疗复发性流产的疗效及对患者凝血功能、Th17细胞相关因子的影响[J].中医药学报,2024,52(8):61-66.[2]刘玉姣,王超,刘菲.寿胎丸合加味圣愈汤加减联合低剂量阿司匹林治疗肾虚血瘀型复发性流产血栓前状态的疗效观察[J].中国妇幼保健,2024,39(14):2668-2672.[3]马飞,罗颂平,郜洁,等.安子调冲汤联合低分子肝素钙治疗肾虚血瘀型复发性流产合并抗磷脂综合征的临床效果[J].中国医药导报,2021,18(27):88-92,109.[4]杨琳,左文婷.益肾安胎化瘀方对肾虚血瘀型早期先兆流产合并绒毛膜下血肿患者凝血指标及妊娠结局的影响[J].中国中西医结合杂志,2024,44(1):31-36.[5]宋亚静,李丹丹,吕竞芳,等.寿胎丸对先兆流产肾虚证模型小鼠母胎界面糖酵解关键蛋白和凋亡相关因子表达的影响[J].中国中药杂志,2024,49(8):2169-2177.[6]徐晓英,牛建丽,陈丽珍.补肾益气止痛安胎方辅助黄体酮注射液治疗先兆性流产对PAPP-A、血β-HCG的变化研究[J].中华中医药学刊,2021,39(7):78-80.[7]戴凌虹,孙云,颜晓钏.补肾固胎方联合黄体酮注射液治疗肾虚型早期先兆流产疗效及对妊娠激素水平和Th1/Th2细胞因子的影响[J].中华中医药学刊,2024,42(3):221-224.[8]丁瑰玲,曾佩.寿胎丸加减内服联合保胎膏外敷治疗早期先兆流产临床疗效[J].辽宁中医杂志,2024,51(1):129-132.[9]董利利,任二女.调冲汤加减联合低分子肝素钙治疗肾虚血瘀型复发性流产合并抗磷脂综合征的临床效果及安全性观察[J].贵州医药,2023,47(4):567-568.[10]夏如意,李艳青,宋艳丽.寿胎丸加味联合黄体酮及低分子肝素治疗复发性流产的临床观察[J].世界中西医结合杂志,2023,18(4):796-800,805.[11]周月希,杜鑫,吕孝丽,等.减味寿胎丸介导妊娠特异性糖蛋白1治疗自然流产的机制[J].中华中医药杂志,2023,38(4):1844-1848.[12]顾姣,史琳茜.“加味补肾安胎饮”对肾虚型早期先兆流产患者性激素水平及免疫功能的影响——附46例临床资料[J].江苏中医药,2023,55(3):27-30.[13]孙六娜,卢如玲,张淑婷,等.寿胎丸对肾虚型多囊卵巢综合征不孕患者子宫内膜容受性及相关因子的影响[J].实用医学杂志,2023,39(3):355-359.[14]丁超,左婧,史话跃.胶艾汤合寿胎丸加减治疗肾虚血瘀型先兆流产临床疗效[J].中国计划生育学杂志,2022,30(12):2744-2748.[15]陈思韵,郜洁,邓咏诗,等.助孕丸干预肾虚、脾肾两虚型早期先兆流产患者妊娠结局的临床研究[J].中华中医药杂志,2022,37(12):6940-6943.[16]王培培.益气补肾方联合黄体酮对肾虚型先兆流产保胎率及对血绒毛膜促性腺激素、孕酮、雌二醇的影响[J].四川中医,2022,40(3):176-178.[17]刘婉利,姜家英.滋肾养胎方辅治对妊娠早期肾虚型高龄先兆流产孕妇症状积分、性激素水平和妊娠结局的影响[J].海南医学,2022,33(4):459-463.[18]张曼俐,杨自力.寿胎丸对先兆流产患者孕酮与雌二醇的影响及保胎效果[J].西北药学杂志,2022,37(1):121-124.[19]谢虹云梦,高晓红,谢波,等.蒲黄炭联合寿胎丸对肾虚型先兆流产合并绒毛膜下血肿患者的影响[J].实用临床医药杂志,2021,25(20):13-17.[20]刁玉芳,宋香金,刘芬,等.寿胎丸加减联合黄体酮注射液对早期肾虚型先兆流产患者疗效、性激素及血清IL-2、IL-6、CRP水平的影响[J].中国性科学,2024,33(4):140-144.[21]曹坤,颜廷卿.中西医结合治疗对早期先兆流产患者的影响[J].中国医药导报,2021,18(18):107-110.[22]曾薇薇,周华,陆齐天,等.补肾活血方联合地屈孕酮片治疗先兆流产合并宫腔积血的临床观察[J].上海中医药大学学报,2020,34(3):26-30.[23]朱海波.地屈孕酮协同黄体酮用于黄体功能不全型先兆流产的疗效分析[J].中国药物与临床,2020,20(9):1525-1527.[24]凌爱华,赵维英.黄体酮联合加味寿胎丸治疗肾虚型早期先兆流产及对炎症因子影响[J].中国计划生育学杂志,2020,28(1):98-101.[25]沈丽梦,李娜,陆子红,等.固肾安胎丸联合黄体酮对先兆流产者的保胎效果及作用机制[J].西北药学杂志,2020,35(1):109-112.

更新日期/Last Update: 1900-01-01