[1]王 楠,刘 伟.环状RNA在急性呼吸窘迫综合征中的研究进展[J].医学信息,2026,39(01):186-192.[doi:10.3969/j.issn.1006-1959.2026.01.036]
 WANG Nan,LIU Wei.Research Progress on Circular RNA in Acute Respiratory Distress Syndrome[J].Journal of Medical Information,2026,39(01):186-192.[doi:10.3969/j.issn.1006-1959.2026.01.036]
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环状RNA在急性呼吸窘迫综合征中的研究进展()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
39卷
期数:
2026年01期
页码:
186-192
栏目:
综述
出版日期:
2026-01-01

文章信息/Info

Title:
Research Progress on Circular RNA in Acute Respiratory Distress Syndrome
文章编号:
1006-1959(2026)01-0186-07
作者:
王 楠12刘 伟2
1.西安医学院研究生院,陕西 西安 710021;2.空军军医大学唐都医院呼吸与危重症医学科,陕西 西安 710038
Author(s):
WANG Nan12 LIU Wei2
1.Graduate School of Xi′an Medical University, Xi′an 710021, Shaanxi, China;2.Department of Pulmonary and Critical Care Medicine, Tangdu Hospital, Fourth Military Medical University,Xi′an 710038, Shaanxi, China
关键词:
环状RNA急性呼吸窘迫综合征生物标志物
Keywords:
Circular RNAs Acute respiratory distress syndrome Biomarker
分类号:
R563
DOI:
10.3969/j.issn.1006-1959.2026.01.036
文献标志码:
A
摘要:
急性呼吸窘迫综合征(ARDS)是一种由肺泡-毛细血管屏障损伤导致非心源性肺水肿的临床综合征,其死亡率高。当前缺乏早期诊断标志物且治疗手段有限。环状RNA(circRNA)作为新型共价闭合非编码RNA,近年来被发现参与了ARDS的进展过程。深入讨论circRNA在ARDS中的作用机制,对于阐明ARDS病理过程及发现新型治疗靶点具有重要意义。本文旨在通过综述现有研究成果,系统总结并探讨circRNA的特性、生物学功能及其在不同病因导致的ARDS中的调控作用,从而为circRNA作为ARDS诊断标志物和治疗靶点提供理论依据。
Abstract:
Acute respiratory distress syndrome (ARDS) is a clinical syndrome characterized by injury to the alveolar-capillary barrier resulting in non-cardiogenic pulmonary edema, and it carries a high mortality rate. Currently, there is a lack of early diagnostic biomarkers and limited therapeutic options. Circular RNAs (circRNAs), a novel class of covalently closed non-coding RNAs, have recently been found to participate in the progression of ARDS. An in-depth discussion of the mechanistic roles of circRNAs in ARDS is crucial for elucidating the pathological processes of ARDS and identifying novel therapeutic targets. This review aims to systematically summarize and explore the characteristics, biological functions, and regulatory roles of circRNAs in ARDS induced by various etiologies, based on current research findings, thereby providing a theoretical foundation for circRNAs as diagnostic biomarkers and therapeutic targets for ARDS.

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更新日期/Last Update: 1900-01-01