[1]胡平华,黄 勤,李志华.含卡培他滨方案一线或后线治疗晚期乳腺癌的效果对比[J].医学信息,2018,31(22):142-144.[doi:10.3969/j.issn.1006-1959.2018.22.041]
　HU Ping-hua,HUANG Qin,LI Zhi-hua.Comparison of the Efficacy of Capecitabine Regimen in the Treatment of Advanced Breast Cancer with First-line or Posterior Line Therapy[J].Journal of Medical Information,2018,31(22):142-144.[doi:10.3969/j.issn.1006-1959.2018.22.041]
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含卡培他滨方案一线或后线治疗晚期乳腺癌的效果对比()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年22期
页码:
142-144
栏目:
药物与临床
出版日期:
2018-11-15

文章信息/Info

Title:
Comparison of the Efficacy of Capecitabine Regimen in the Treatment of Advanced Breast Cancer with First-line or Posterior Line Therapy
文章编号:
1006-1959（2018）22-0142-03
作者:
胡平华; 黄 勤; 李志华
（南昌市第三医院乳腺肿瘤科，江西 南昌 330000）
Author(s):
HU Ping-hua; HUANG Qin; LI Zhi-hua
(Department of Breast Cancer,the Third Hospital of Nanchang,Nanchang 330000,Jiangxi,China)
关键词:
卡培他滨; 乳腺癌; 治疗方案; 晚期
Keywords:
Capecitabine; Breast cancer; Treatment regimen; Advanced stage
分类号:
R737.9
DOI:
10.3969/j.issn.1006-1959.2018.22.041
文献标志码:
A
摘要:
目的 对比观察含卡培他滨方案一线或后线治疗晚期乳腺癌的效果。方法 选取2013年1月~2016年2月我院收治的95例晚期乳腺癌患者作为研究对象，按照卡培他滨出现方案分为一线组（27例）、二线组（35例）、三线组（33例）,观察其疗效和安全性。结果 治疗效果方面，一线组的完全缓解（CR）、客观有效率（ORR）、临床获益率（CBR）均高于三线组（P＜0.05），疾病进展（PD）低于三线组（P＜0.05）；二线组的PD低于三线组（P＜0.05），CBR上高于三线组（P＜0.05）。三组安全性比较，差异无统计学意义（P＞0.05）。结论 相较于三线方案，一线或二线方案含卡培他滨治疗晚期乳腺癌患者，在控制和缓解患者癌细胞方面具有较好作用；而卡培他滨出现何种方案中并不会增加安全性事件；推荐临床应用一线或二线方案含卡培他滨。
Abstract:
Objective To compare the efficacy of capecitabine regimen in the treatment of advanced breast cancer with first-line or posterior line therapy.Methods 95 patients with advanced breast cancer admitted in our hospital from January 2013 to February 2016 were selected as study subjects.According to capecitabine regimen, the patients were divided into first line group(27 cases), second line group(35 cases) and third line group(33 cases). The efficacy and safety of capecitabine were observed.Results In terms of therapeutic effect,the complete remission (CR),objective efficiency rate (ORR),clinical benefit rate(CBR) of the first group was higher than that in the third line group (P<0.05).The progression of disease (PD) was lower than that of the third line group(P<0.05).The PD of the second line group was lower than that of the third line group(P<0.05) and its CBR was higher than that in the third line group (P<0.05).There was no significant difference in safety among the three groups(P>0.05).Conclusion Compared with the three-line regimen, the first-line or second-line regimen with capecitabine in the treatment of patients with advanced breast cancer,it has a good effect in controlling and relieving cancer cells in patients.And it does not increase security events that which kind of regimen capecitabine was in.It is recommended that the first or second line regimen include capecitabine.

参考文献/References:


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更新日期/Last Update: 2018-12-03