[1]张小艳,赵 红,郑穗生,等.食管癌患者放射性肺损伤预测因素分析及其与 COPD的相关性研究[J].医学信息,2019,32(14):68-71.[doi:10.3969/j.issn.1006-1959.2019.14.022]
　ZHANG Xiao-yan,ZHAO Hong,ZHENG Sui-sheng,et al.Predictive Factors Analysis of Radiation-Induced Lung Injury in Patients with Esophageal Cancer and Its Correlation with COPD[J].Journal of Medical Information,2019,32(14):68-71.[doi:10.3969/j.issn.1006-1959.2019.14.022]
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食管癌患者放射性肺损伤预测因素分析及其与 COPD的相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年14期
页码:
68-71
栏目:
论著
出版日期:
2019-07-15

文章信息/Info

Title:
Predictive Factors Analysis of Radiation-Induced Lung Injury in Patients with Esophageal Cancer and Its Correlation with COPD
文章编号:
1006-1959（2019）14-0068-04
作者:
张小艳1; 赵 红1; 郑穗生1; 祁 闻1; 李春阳2; 杨 进3
安徽医科大学第二附属医院放射科1，放疗科2，呼吸科3，安徽 合肥 230601
Author(s):
ZHANG Xiao-yan1; ZHAO Hong1; ZHENG Sui-sheng1;  QI Wen1; LI Chun-yang2; YANG Jin3
Department of Radiology1,Department of Radiotherapy2,Department of Respiratory Diseases3, the Second Affiliated Hospital of Anhui Medical University,Hefei 230601,Anhui,China
关键词:
食管癌; 放射性肺损伤; 慢性阻塞性肺疾病; 立体定向放射治疗
Keywords:
Key words：Esophageal cancer; Radiation-induced lung injury; Chronic obstructive pulmonary disease; Stereotactic body radiotherapy therapy
分类号:
R735.1；R730.55
DOI:
10.3969/j.issn.1006-1959.2019.14.022
文献标志码:
A
摘要:
目的 分析食管癌患者放射性肺损伤（RILI）预测因素，以及其与慢性阻塞性肺疾病（COPD）的相关性。方法 选取2014年1月~2017年12月我院收治的食管癌患者265例为研究对象，均行立体定向放射治疗（SBRT）治疗，治疗前均行肺功能检查，治疗后均行HRCT检查随访RILI的发生情况，回顾性分析RILI的预测因素及其与COPD是否存在相关性。结果 0、1、2、3、4、5级RP发生率分别为38.49%、38.11%、17.74%、5.28%、0.38%、0，其中12例患有间质性肺疾病的患者，9例（75.00%）发生例3级以上的RILI；发生RILI≥1级的相关因素有年龄、总剂量、V20、GOLD分级；重度及极重度COPD组患者的0级RILI的发生率为54.17%，高于轻中度COPD组（42.31%）及无COPD组（30.22%）。结论 年龄、总剂量、V20、GOLD分级与1级以上（有影像学变化）的RILI有相关性，重度COPD的RILI较正常或轻度COPD患者相对较轻，患有间质性肺疾病的患者多发生3级以上的RILI。
Abstract:
Abstract：Objective To analyze the predictive factors of radiation-induced lung injury (RILI) in patients with esophageal cancer and its correlation with chronic obstructive pulmonary disease (COPD). Methods A total of 265 patients with esophageal cancer admitted to our hospital from January 2014 to December 2017 were enrolled in the study. All patients underwent stereotactic radiotherapy (SBRT). All patients underwent pulmonary function tests before treatment. All patients underwent HRCT follow-up after treatment. The incidence of radiation-induced lung injury,retrospective analysis of predictors of radiation-induced lung injury and its association with COPD.Results The incidence rates of 0, 1, 2, 3, 4, and 5 RP were 38.49%, 38.11%, 17.74%, 5.28%, 0.38%, and 0, of which 12 patients with interstitial lung disease and 9 patients (75.00%) Radioactive lung injury occurred in grade 3 or higher; age-related, total-dose, V20, and GOLD grades were associated with RILI ≥ 1 grade; grade 5 RILI was 54.17% in patients with severe and very severe COPD,higher than mild to moderate COPD group (42.31%) and no COPD group (30.22%).Conclusion The age, total dose,V20, and GOLD grades are related to RILI of grade 1 or above (with imaging changes). Severe chronic obstructive pulmonary disease (RILI) is relatively mild compared with normal or mild chronic obstructive pulmonary disease. More than grade 3 radiation-induced lung injury occurs in patients with pulmonary disease.

参考文献/References:

[1]鲁之中,李军民,胡云芝,等.食管癌患者miR-182表达水平及其对预后的影响[J].中国现代医学杂志,2017,27(24):39-43. [2]秦福双.MRI对食管癌T分期诊断及手术切除中的评估价值分析[J].中国CT和MRI杂志,2018,16(1):94-97. [3]周凯,王伟,相加庆.新辅助化放疗联合手术治疗局部晚期食管癌30例[J].中国临床研究,2018,31(10):85-88. [4]王绿化,傅小龙,陈明,等.放射性肺损伤的诊断及治疗[J].中华放射肿瘤学杂志,2015,24(1):4-9. [5]郑苗丽,冯勤付.放射性肺损伤的研究进展[J].中华放射肿瘤学杂志,2018,27(7):692-695. [6]Rabe KF,Hurd S,Anzueto A,et al.Global Initiative forChronic Obstructive Lung Disease.Global strategy for the diagnosis,management,and prevention of chronic obstructive pulmonary disease: GOLD executive summary[J].Am J Respir Crit Care Med,2007,176(6):532-555. [7]闵茜,胡伟国,宋启斌.放射性肺损伤发生机制的研究进展[J].肿瘤学杂志,2016,22(2):88-92. [8]林佳.胸部肿瘤放疗后致急性放射性肺损伤的相关因素分析[J].现代诊断与治疗,2017,28(17):3242-3244. [9]Kimura T,Togami T,Takashima H,et al.Radiation pneumonitisin patients with lung and mediastinal tumours:a retrospective study of risk factors focused on pulmonary emphysema[J].Br J Radiol,2012(85):135-141. [10]Takeda A,Kunieda E,OhasPhi T,et al.Severe COPD is correlated with mild radiation pneumonitis following stereotactic body radiotherapy[J].Chest,2012,141(4):858-866. [11]张毅,任秦有,郑瑾,等.放射性肺损伤的研究进展[J].现代肿瘤医学,2015,28(5):712-715. [12]常晓龙,王明臣,刘雪,等.盐酸氨溴索在放射性肺损伤中的保护作用及对血浆TGF-β1和TNF-α水平的影响[J].广州医药,2015,46(1):8-10. [13]Takeda A,Ohashi T,Kunieda E,et al.Early graphical appearance of radiation pneumonitis correlates with the severity of radiation pneumonitis after stereo tactic body radiotherapy(SBRT) in patients with lung tumors[J].Int J Radiat Oncol Biolhys,2010,77(3):685-690. [14]Yamashita H,Kobayashi-Shibata S,Terahara A,et al.Prescreening based on the presence of CT-scan abnormalities and biomarkers(KL-6 and SP-D)may reduce severe radiation pneumonitis after stereotactic radiotherapy[J].Radiat Oncol,2010(5):32. [15]杨志勇,陈传喜.非小细胞肺癌患者放射性肺损伤的临床特点分析[J].中国肿瘤临床与康复,2015,21(1):7-8. [16]王志勇.三维适形放疗并发放射性肺炎的CT影像特点[J].中国医药指南,2017,15(19):159-160.

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更新日期/Last Update: 2019-07-15