[1]华 琳,陈元旺,唐 静,等.溃疡性结肠炎患者外周血Tim-4 mRNA表达水平的变化及意义[J].医学信息,2019,32(21):161-163.[doi:10.3969/j.issn.1006-1959.2019.21.054]
　HUA Lin,CHEN Yuan-wang,TANG Jing,et al.Changes and Significance of Tim-4 mRNA Expression in Peripheral Blood of Patients with Ulcerative Colitis[J].Journal of Medical Information,2019,32(21):161-163.[doi:10.3969/j.issn.1006-1959.2019.21.054]
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溃疡性结肠炎患者外周血Tim-4 mRNA表达水平的变化及意义()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年21期
页码:
161-163
栏目:
诊疗技术
出版日期:
2019-11-01

文章信息/Info

Title:
Changes and Significance of Tim-4 mRNA Expression in Peripheral Blood of Patients with Ulcerative Colitis
文章编号:
1006-1959（2019）21-0161-03
作者:
华 琳1; 陈元旺2; 唐 静1; 刘晓峰1; 薛国辉1
（九江市第一人民医院检验科1，消化内科2，江西 九江 332000）
Author(s):
HUA Lin1; CHEN Yuan-wang2; TANG Jing1; LIU Xiao-feng1; XUE Guo-hui1
(Department of Clinical Laboratory1,Department of Gastroenterology2,Jiujiang First People's Hospital,Jiujiang332000,Jiangxi,China)
关键词:
溃疡性结肠炎; Tim-4; C反应蛋白; 红细胞沉降率
Keywords:
Ulcerative colitis; Tim-4; C-reactive protein; Erythrocyte sedimentation rate
分类号:
R574.62
DOI:
10.3969/j.issn.1006-1959.2019.21.054
文献标志码:
A
摘要:
目的 探究溃疡性结肠炎患者外周血Tim-4 mRNA的表达变化及临床意义。方法 选取2015年2月~2019年4月我院收治的溃疡性结肠炎患者38例作为观察组，另选取同期来我院体检的健康者30名作为对照组，采用荧光定量PCR测定外周血Tim-4 mRNA表达水平，比较两组Tim-4 mRNA、C反应蛋白（CRP）、红细胞沉降率（ESR）表达水平及观察组Tim-4 mRNA与CRP和ESR的相关性。结果 观察组Tim-4 mRNA、CRP、ESR表达均高于对照组[（0.79±0.37）vs（0.33±0.20）]、[（6.08±3.21）mg/L vs（0.99±0.87）mg/L]、[（19.12±12.13）mm/h vs（5.58±4.10）mm/h]，差异有统计学意义（P＜0.05）。观察组外周血单个核细胞Tim-4 mRNA表达水平与CRP呈正相关（r=0.376，P＜0.05），而与ESR无相关性（r=0.077，P＞0.05）。结论 溃疡性结肠炎患者Tim-4 mRNA异常上调，并与CRP密切相关，可能参与溃疡性结肠炎的致病过程。
Abstract:
Objective To investigate the expression and clinical significance of Tim-4 mRNA expression in peripheral blood of patients with ulcerative colitis.Methods A total of 38 patients with ulcerative colitis admitted to our hospital from February 2015 to April 2019 were enrolled as the observation group. 30 healthy subjects from our hospital for the same period were selected as the control group. The expression of Tim-4 mRNA in peripheral blood was determined by real-time PCR. The expressions of Tim-4 mRNA, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) in the two groups and the correlation between Tim-4 mRNA and CRP and ESR in the observation group were compared.Results The expressions of Tim-4 mRNA, CRP and ESR in the observation group were higher than those in the control group [(0.79±0.37) vs (0.33±0.20)], [(6.08±3.21) mg/L vs (0.99±0.87) mg/L], [(19.12±12.13) mm/h vs (5.58±4.10) mm/h], the difference was statistically significant (P<0.05). The expression of Tim-4 mRNA in peripheral blood mononuclear cells of the observation group was positively correlated with CRP (r=0.376, P<0.05), but not correlated with ESR (r=0.077, P>0.05). Conclusion The abnormal expression of Tim-4 mRNA in patients with ulcerative colitis is closely related to CRP and may be involved in the pathogenesis of ulcerative colitis.

参考文献/References:

[1]孙健,文艳,林一帆.溃疡性结肠炎病因和发病机制研究进展[J].辽宁中医药大学学报,2017(4):94-97. [2]刘笃佳,王媛媛,马旭.溃疡性结肠炎的流行病学研究进展[J].中国烧伤创疡杂志,2017,29(3):214-217. [3]Zhang SL,Wang SN,Miao CY.Influence of Microbiota on Intestinal Immune System in Ulcerative Colitis and Its Intervention[J].Frontiers in Immunology,2017(8):1674. [4]吴昊,夏盛隆,夏宣平,等.结肠组织中Th1/Th2和Th17细胞失衡与溃疡性结肠炎的关系[J].解放军医学杂志,2017,42(9):49-54. [5]中华医学会消化病学分会炎症性肠病学组.炎症性肠病诊断与治疗的共识意见(2012年·广州)[J].胃肠病学,2012,51(12):818-831. [6]Miyanishi M,Tada K,Koike M,et al.Identification of Tim4 as a phosphatidylserine receptor[J].Nature,2007,450(7168):435-439. [7]Zhang X,Liu Q,Wang J,et al.TIM-4 is differentially expressed in the distinct subsets of dendritic cells in skin and skin-draining lymph nodes and controls skin Langerhans cell homeostasis[J].Oncotarget,2016,7(25):37498-37512. [8]Fang XY,Xu WD,Pan HF,et al.Novel insights into Tim-4 function in autoimmune diseases[J].Autoimmunity,2015,48(4):189-195.

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更新日期/Last Update: 2019-11-01