[1]阮泓寅,孙 斌.唾液腺癌靶向治疗的研究[J].医学信息,2020,33(13):38-42.[doi:10.3969/j.issn.1006-1959.2020.13.011]
 RUAN Hong-yin,SUN Bin.Study on Targeted Therapy of Salivary-gland Carcinoma[J].Medical Information,2020,33(13):38-42.[doi:10.3969/j.issn.1006-1959.2020.13.011]
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唾液腺癌靶向治疗的研究()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年13期
页码:
38-42
栏目:
综述
出版日期:
2020-07-01

文章信息/Info

Title:
Study on Targeted Therapy of Salivary-gland Carcinoma
文章编号:
1006-1959(2020)13-0038-05
作者:
阮泓寅孙 斌
(1.石河子大学医学院,新疆 石河子 832003;2.石河子大学一附院口腔科,新疆 石河子 832008)
Author(s):
RUAN Hong-yinSUN Bin
(1.Medical College,Shihezi University,Shihezi 832003,Xinjiang,China;2.Department of Stomatology,the First Affiliated Hospital of Shihezi University,Shihezi 832008,Xinjiang,China)
关键词:
唾液腺恶性肿瘤靶向治疗融合基因
Keywords:
Salivary glandMalignant tumorTargeted therapyFusion gene
分类号:
R739.87
DOI:
10.3969/j.issn.1006-1959.2020.13.011
文献标志码:
A
摘要:
唾液腺癌(SGC)是头颈部恶性肿瘤,异质性高,组织病理类型多样,使其成为复杂的头颈病疾病之一。复发和远处转移是肿瘤预后不良的因素之一,针对SGC患者的靶向治疗可显著改善患者的预后。不同组织学类型存在特异性融合基因或广泛的基因突变,寻找适当的靶点是唾液腺恶性肿瘤靶向治疗面临的挑战和机遇。本文就SGC组织学亚型中粘液表皮样癌、腺样囊性癌、涎腺分泌癌、腺泡细胞癌、多形性腺瘤恶变、唾液腺导管癌、未分类腺癌、恶性混合瘤的靶向治疗现状作一综述,以期为临床治疗提供参考。
Abstract:
Salivary-gland carcinoma(SGC) is a malignant tumor of the head and neck, with high heterogeneity and diverse histopathological types, making it one of the complicated head and neck diseases. Recurrence and distant metastasis are one of the factors of poor tumor prognosis. Targeted therapy for SGC patients can significantly improve the prognosis of patients. Different histological types have specific fusion genes or extensive gene mutations. Finding appropriate targets is the challenge and opportunity for salivary-gland carcinoma targeted therapy. This article focuses on the targeting of mucoepidermoid carcinoma, adenoid cystic carcinoma, salivary gland secretory carcinoma, acinar cell carcinoma, pleomorphic adenoma malignant transformation, salivary duct carcinoma, unclassified adenocarcinoma, and malignant mixed tumor the current status of treatment is reviewed to provide a reference for clinical treatment.

参考文献/References:

[1]El-Naggar AKCJ,Grandis JR,Takata T,et al.WHO classification of head and neck tumours[M].4th ed.Lyon:IARC,2017.[2]Nam SJ,Roh JL,Cho KJ,et al.Risk factors and survival associated with distant metastasis in patients with carcinoma of the salivary gland[J].Ann Surg Oncol,2016,23(13):4376-4383.[3]Rajasekaran K,Stubbs V,Chen J,et al.Mucoepidermoid carcinoma of the parotid gland:a National Cancer Database study[J].Am J Otolaryngol,2018,39(3):321-326.[4]Chen MM,Roman SA,Sosa JA,et al.Histologic grade as prognostic indicator for mucoepidermoid carcinoma: apopulation-level analysis of 2400 patients[J].Head Neck,2014,36(2):158-163.[5]Seethala RR,Stenman G.Update from the 4th edition of the World Health Organization classification of head and neck tumours: tumors of thesalivary gland[J].Head Neck Pathol,2017,11(1):55-67.[6]Li S,Zhang Z,Tang H,et al.Pathological complete response to getinib in a 10-year-old boy with EGFR-negative pulmonary mucoepidermoid carcinoma:a case report and literature review[J].Clin Resp,2017,11(3):346-351.[7]Wong SJ,Karrison T,Hayes DN,et al.Phase II trial of dasatinib for recurrent or metastatic c-KIT expressing adenoid cystic carcinoma and for nonadenoid cystic malignant salivary tumors[J].Eur Soc Med Oncol,2016,27(2):318-323.[8]支旺,温惠慧,崔志强.唾液腺腺样囊性癌组织中EGFR的表达及临床意义[J].长治医学院报,2017,31(2):98-100.[9]王蕊,李立恒,朱晓龙,等.涎腺腺样囊性癌中微血管密度与血管内皮生长因子的表达水平及临床意义[J].山西医药杂志,2017,46(22):2749-2751.[10]Agulnik M,Cohen EW,Cohen RB,et al.Phase II Study of Lapatinib in Recurrent or Metastatic Epidermal Growth Factor Receptor and/or erbB2 Expressing Adenoid Cystic Carcinoma and Non Adenoid Cystic Carcinoma Malignant Tumors of the Salivary Glands[J].Am Soc Clin Oncol,2007,25(25):3978-3984.[11]Tchekmedyian V,Sherman EJ,Dunn L,et al.Phase II Study of Lenvatinib in Patients With Progressive, Recurrent or Metastatic Adenoid Cystic Carcinoma[J].Am Soc Clin Oncol,2019,37(18):1529-1537.[12]Fujii K,Murase T,Beppu S,et al.MYB,MYBL1,MYBL2 and NFIB gene alterations and MYC overexpression in salivary gland adenoid cystic carcinoma[J].Histopathology,2017,71(5):823-834.[13]Andersson MK,Afshari MK,Andren Y,et al.Targeting the oncogenic transcriptional regulator MYB in adenoid cystic carcinoma by inhibition of IGF1R/AKT Signaling[J].Natl Cancer Inst,2017,109(9):10.[14]Ferrarotto R,Mitani Y,Diao L,et al.Activating NOTCH1 mutations define a distinct subgroup of patients with adenoid cystic carcinoma who have poor prognosis, propensity to bone and liver metastasis, and potential responsiveness to notch1 inhibitors[J].Am Soc Clin Oncol,2017,35(3):352-360.[15]Ferrarotto R Eckhardt G,Patnaik A,et al.A phase I dose-escalation and dose-expansion study of brontictuzumab in subjects with selected solid tumors[J].Eur Soc Med Oncol,2018,29(7):1561-1568.[16]Even C,Lassen U,Merchan J,et al.Safety and clinical activity of the Notch inhibitor,crenigacestat(LY3039478),in an openlabel phase I trial expansion cohort of advanced or metastatic adenoid cystic carcinoma[J].Invest New Drugs,2019,38(2):402-409.[17]Ferdinandus J,Violet J,Sandhu S,et al.Prostate-specific membrane antigen theranostics:therapy with lutetium-177[J].Curr Opin Urol,2018,28(2):197-204.[18]Skalova A,Vanecek T,Martinek P,et al.Molecular profiling of mammary analog secretory carcinoma revealed a subset of tumors harboring a novel ETV6-RET translocation: report of 10 cases[J].Am J Surg Pathol,2018,42(2):234-246.[19]Cocco E,Scaltriti M,Drilon A.NTRK fusion-positive cancers and TRK inhibitor therapy[J].Nat Rev Clin Oncol,2018,15(12):731-747.[20]Biron VL,Lentsch EJ,Gerry DR,et al.Factors influencing survival in acinic cell carcinoma:a retrospective survival analysis of 2061 patients[J].Head Neck,2015,37(6):870-877.[21]Andreasen S,Varma S,Barasch N,et al.The HTN3-MSANTD3 fusion gene defines a subset of acinic cell carcinoma of the salivary gland[J].Am J Surg Pathol,2019,43(4):489-496.[22]Solomon JP,Linkov I,Rosado A,et al.NTRK fusion detection across multiple assays and 33,997 cases: diagnostic implications and pitfalls[J].Mod Pathol,2020,33(1):38-46.[23]Hernandez-Prera JC.Historical evolution of the polymorphous adenocarcinoma[J].Head Neck Pathol,2019,13(3):415-422.[24]Weinreb I,Piscuoglio S,Martelotto LG,et al.Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands[J].Nat Genet,2014,46(11):1166-1169.[25]Otsuka K,Imanishi Y,Tada Y,et al.Clinical outcomes and prognostic factors for salivary duct carcinoma:a multi-institutional analysis of 141 patients[J].Ann Surg Oncol,2016,23(6):2038-2045.[26]Boon E,BelM,vanBoxtel W,et al.A clinicopathological study and prognostic factor analysis of 177 salivary duct carcinoma patients from The Netherlands[J].Cancer,2018,143(4):758-766.[27]Takase S,Kano S,Tada Y,et al.Biomarker immunoprole in salivary duct carcinomas:clinicopathological and prognostic implications with evaluation of the revised classification[J].Oncotarget,2017,8(35):59023-59035.[28]Fushimi C,Tada Y,Takahashi H,et al.A prospective phase II study of combined androgen blockade in patients with androgen receptor-positive metastatic or locally advanced unresectable salivary gland carcinoma[J].Eur Soc Med Oncol,2018,29(4):979-984.[29]van Boxtel W,Locati LD,van Engen-van Grunsven ACH,et al.Adjuvant androgen deprivation therapy for poor-risk,androgen receptor-positive salivary duct carcinoma[J].Eur J Cancer,2019(110):62-70.[30]Takahashi H,Tada Y,Saotome T,et al.Phase II trialoftrastuzumabanddocetaxel inpatients withhumanepidermalgrowthfactor receptor 2-positive salivary duct carcinoma[J].Am Soc Clin Oncol,2019,37(2):125-134.[31]Shimura T,Tada Y,Hirai H,et al.Prognostic and histogenetic roles of gene alteration and the expression of key potentially actionable targets in salivary duct carcinomas[J].Oncotarget,2018,9(2):1852-1867.[32]Bjorndal K,Krogdahl A,Therkildsen MH,et al.Salivary gland carcinoma in Denmark 1990-2005:a national study of incidence,site and histology.Results of the Danish Head and Neck Cancer Group (DAHANCA)[J].Oral Oncol,2011,47(7):677-682.[33]Hu YH,Li W,Zhang CY,et al.Prognostic nomogram for disease-speciic survival of carcinoma ex pleomorphic adenoma of the salivary gland[J].Head Neck,2017,39(12):2416-2424.[34]Asahina M,Saito T,Hayashi T,et al.Clinicopathological effect of PLAG1 fusion genes in pleomorphic adenoma and carcinoma ex pleomorphic adenoma with special emphasis on histological features[J].Histopathology,2019,74(3):514525.

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更新日期/Last Update: 1900-01-01