[1]成若晨,张 璎,何腾飞,等.原卟啉Ⅸ在HBV相关肝硬化中的临床意义[J].医学信息,2021,34(06):73-77.[doi:10.3969/j.issn.1006-1959.2021.06.019]
　CHENG Ruo-chen,ZHANG Ying,HE Teng-fei,et al.The Clinical Significance of Protoporphyrin Ⅸ in HBV-related Liver Cirrhosis[J].Medical Information,2021,34(06):73-77.[doi:10.3969/j.issn.1006-1959.2021.06.019]
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原卟啉Ⅸ在HBV相关肝硬化中的临床意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年06期
页码:
73-77
栏目:
论著
出版日期:
2021-03-15

文章信息/Info

Title:
The Clinical Significance of Protoporphyrin Ⅸ in HBV-related Liver Cirrhosis
文章编号:
1006-1959（2021）06-0073-05
作者:
成若晨; 张 璎; 何腾飞; 等
（西安医学院临床医学院，陕西 西安 710021）
Author(s):
CHENG Ruo-chen; ZHANG Ying; HE Teng-fei; et al.
(Clinical School,Xi’an Medical University,Xi’an 710021,Shaanxi,China)
关键词:
乙型病毒性肝炎; 肝硬化; 原卟啉Ⅸ
Keywords:
Viral hepatitis B; Liver cirrhosis; Protoporphyrin Ⅸ
分类号:
R575
DOI:
10.3969/j.issn.1006-1959.2021.06.019
文献标志码:
A
摘要:
目的 探讨原卟啉Ⅸ（PPⅨ）在乙型肝炎病毒（HBV）相关肝硬化患者肝功能及抗病毒疗效评估中的临床意义。方法 选择2018年10月~2019年10月就诊于西安医学院第一附属医院的51例HBV相关肝硬化患者作为肝硬化组，另选同期本院40名健康人群作为对照组；采用高效液相色谱法（HPLC）检测两组血清PPⅨ水平，分析PPⅨ与常规实验室指标对肝功能、抗病毒治疗效果的评估价值。结果 肝硬化组PPⅨ水平高于对照组，且肝硬化组Child-Pugh A、B、C 各级患者PPⅨ水平均高于对照组，差异有统计学意义（P＜0.05）；肝硬化组Child-Pugh A级患者PPⅨ水平高于B、C 级，差异有统计学意义（P＜0.05），而Child-Pugh B、C级患者PPⅨ水平比较，差异无统计学意义（P＞0.05）；PPⅨ与Child-Pugh评分、APRI评分、FIB-4评分、TBIL、AST、ALT、ALB、PLT、PT 均呈正相关（P＜0.05），与HBV-DNA、ALP、GGT 无相关性（P＞0.05）；ROC曲线显示，Child-Pugh＞7分时，PPⅨ评估Child-Pugh评分的曲线下面积（AUC）为 0.853，临界值 62.05 ng/dl，灵敏度86.20%，特异度 75.00%，95%CI：0.781~0.952；肝硬化组治疗前、治疗12、24周后，患者血清PPⅨ、TBIL水平依次降低，差异有统计学意义（P＜0.05），HBV-DNA、AST、ALT、ALB、PT水平与治疗前比较，差异有统计学意义（P＜0.05），治疗前后PLT、ALP、GGT水平比较，差异无统计学意义（P＞0.05）。结论 肝硬化患者原卟啉Ⅸ水平高于健康人群，该指标可作为评估乙肝肝硬化患者肝功能损害的预警因子，也可用于抗HBV治疗效果的评估。
Abstract:
Objective To explore the clinical significance of protoporphyrin Ⅸ (PPⅨ) in the evaluation of liver function and antiviral efficacy in patients with hepatitis B virus (HBV)-related cirrhosis.Methods 51 patients with HBV-related cirrhosis who were admitted to the First Affiliated Hospital of Xi’an Medical University from October 2018 to October 2019 were selected as the cirrhosis group, and 40 healthy people in the hospital during the same period were selected as the control group;High performance liquid chromatography (HPLC) was used to detect the levels of serum PPⅨ in the two groups, and the evaluation value of PPⅨ and routine laboratory indicators on liver function and antiviral treatment effects were analyzed.Results Before treatment, the PPⅨ level of the cirrhosis group was higher than that of the control group, and the PPⅨ level of Child-Pugh A, B, C patients in the liver cirrhosis group was higher than that of the control group, the difference was statistically significant (P<0.05);The PPⅨ level of Child-Pugh A patients in the liver cirrhosis group was higher than that of B and C,the difference was statistically significant (P＜0.05).However, there was no statistically significant difference in the PPⅨ level of Child-Pugh B and C patients (P>0.05);PPⅨ was positively correlated with Child-Pugh score, APRI score, FIB-4 score, TBIL, AST, ALT, ALB, PLT, PT (P<0.05),no correlation with HBV-DNA, ALP, GGT (P>0.05);The ROC curve showed that when Child-Pugh>7 points, the area under the curve (AUC) for PPIX assessment of Child-Pugh score was 0.853, the cut-off value was 62.05 ng/dl, the sensitivity was 86.20%, the specificity was 75.00%, and the 95% CI: 0.781~ 0.952; before treatment and after 12 and 24 weeks of treatment in the liver cirrhosis group, the serum levels of PPⅨ and TBIL decreased successively,the difference was statistically significant (P<0.05).HBV-DNA, AST, ALT, ALB, PT levels were compared with those before treatment, the difference was statistically significant (P<0.05),There was no statistically significant difference in the levels of PLT, ALP, and GGT before and after treatment (P>0.05).Conclusion The level of protoporphyrin IX in patients with liver cirrhosis is higher than that in healthy people. This indicator can be used as an early warning factor for evaluating liver damage in patients with hepatitis B cirrhosis, and it can also be used to evaluate the effect of anti-HBV treatment.

参考文献/References:

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