[1]郑少燕,张志英,朱丹萍,等.糖类抗原125、B型钠尿肽评价慢性心力衰竭患者心功能的价值[J].医学信息,2021,34(19):104-106.[doi:10.3969/j.issn.1006-1959.2021.19.026]
　ZHENG Shao-yan,ZHANG Zhi-ying,ZHU Dan-ping,et al.The Value of Carbohydrate Antigen 125 and B-type Natriuretic Peptide inEvaluating Cardiac Function in Patients with Chronic Heart Failure[J].Medical Information,2021,34(19):104-106.[doi:10.3969/j.issn.1006-1959.2021.19.026]
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糖类抗原125、B型钠尿肽评价慢性心力衰竭患者心功能的价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年19期
页码:
104-106
栏目:
论著
出版日期:
2021-10-01

文章信息/Info

Title:
The Value of Carbohydrate Antigen 125 and B-type Natriuretic Peptide inEvaluating Cardiac Function in Patients with Chronic Heart Failure
文章编号:
1006-1959（2021）19-0104-03
作者:
郑少燕; 张志英; 朱丹萍; 范雪婷; 刘松坚
火箭军广州特勤疗养中心检验科，广东 广州 510515
Author(s):
ZHENG Shao-yan; ZHANG Zhi-ying; ZHU Dan-ping; FAN Xue-ting; LIU Song-jian
Laboratory of Rocket Army Guangzhou Special Service Convalescent Center,Guangzhou 510515,Guangdong,China
关键词:
B型脑钠肽; 糖类抗原125; 慢性心力衰竭; 心功能
Keywords:
B-type brain natriuretic peptide; Carbohydrate antigen 125; Chronic heart failure; Cardiac function
分类号:
R541.6
DOI:
10.3969/j.issn.1006-1959.2021.19.026
文献标志码:
A
摘要:
目的 探讨外周血清糖类抗原125（CA125）、B型钠尿肽（BNP）水平与慢性心力衰竭（CHF）患者心功能的相关性。方法 选择2017年3月-2019年3月我院收治的106例CHF患者，根据NYHA心功能分级标准分为Ⅰ~Ⅱ级组、Ⅲ级组、Ⅳ级组，均行血清CA125、BNP和心脏彩超检查，比较各组CA125、BNP与心功能指标（NYHA分级、LA、LVEDD、LVEF）水平，分析其与患者预后的关系，比较不同CA125、BNP水平患者再入院率、死亡率差异。结果 Ⅰ~Ⅱ级组、Ⅲ级组、Ⅳ级组CA125、BNP水平均依次升高，LVEF水平依次降低，差异均有统计学意义（P＜0.05）；Ⅰ~Ⅱ级组LA、LVEDD水平低于Ⅲ级组、Ⅳ级组，差异有统计学意义（P＜0.05），Ⅲ级组、Ⅳ级组LA、LVEDD水平比较，差异无统计学意义（P＞0.05）；相关性分析显示，CHF患者血清CA125与NYHA分级呈正相关，与LVEF呈负相关，与LA、LVEDD无相关性；CHF患者血清BNP与NYHA分级、LA、LVEDD均呈正相关，与LVEF呈负相关；CA125水平正常患者的再住院率低于异常患者，BNP正常的患者再住院率低于异常患者，差异均有统计学意义（P＜0.05）。结论 CHF患者的心功能受损程度与外周血CA125、BNP水平均呈正相关，检测CHF患者的血清CA125及BNP水平，可为临床评估患者心功能状态及预后状况提供参考。
Abstract:
Objective To investigate the correlation between serum carbohydrate antigen 125 (CA125) and B-type natriuretic peptide (BNP) levels and cardiac function in patients with chronic heart failure (CHF).Methods A total of 106 CHF patients admitted to our hospital from March 2017 to March 2019 were selected and divided into grade Ⅰ-Ⅱ group, grade Ⅲ group and grade Ⅳ group according to NYHA cardiac function classification standard. Serum CA125, BNP and echocardiography were performed. The levels of CA125, BNP and cardiac function indexes (NYHA classification, LA, LVEDD, LVEF) in each group were compared, the relationship between CA125, BNP and prognosis of patients was analyzed, and the readmission rate and mortality of patients with different CA125 and BNP levels were compared.Results The levels of CA125 and BNP in grade Ⅰ-Ⅱ group, grade Ⅲ group and grade Ⅳ group increased in turn, and the LVEF level decreased in turn, the differences were statistically significant (P<0.05). The levels of LA and LVEDD in grade Ⅰ-Ⅱ group were lower than those in grade Ⅲ and Ⅳ groups, and the difference was statistically significant (P<0.05), while there was no statistically significant difference in LA and LVEDD levels between grade Ⅲ group and grade Ⅳ group (P>0.05). Correlation analysis showed that serum CA125 in CHF patients was positively correlated with NYHA classification, negatively correlated with LVEF, and had no correlation with LA and LVEDD. The serum BNP of CHF patients was positively correlated with NYHA classification, LA, LVEDD, and negatively correlated with LVEF. The rehospitalization rate of patients with normal CA125 level was lower than that of patients with abnormal CA125 level, and the rehospitalization rate of patients with normal BNP level was lower than that of patients with abnormal BNP level, and the differences were statistically significant (P<0.05).Conclusion The degree of cardiac function damage in CHF patients is positively correlated with peripheral blood CA125 and BNP levels. Detection of serum CA125 and BNP levels can provide reference for clinical evaluation of cardiac function and prognosis.

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更新日期/Last Update: 1900-01-01