[1]陈孝辉.无创呼吸机联合N-乙酰半胱氨酸治疗急性呼吸衰竭的临床疗效[J].医学信息,2022,35(02):121-123.[doi:10.3969/j.issn.1006-1959.2022.02.029]
　CHEN Xiao-hui.Clinical Efficacy of Non-invasive Ventilator Combined with N-acetyl L-cysteinein Treatment of Acute Respiratory Failure[J].Medical Information,2022,35(02):121-123.[doi:10.3969/j.issn.1006-1959.2022.02.029]
点击复制

无创呼吸机联合N-乙酰半胱氨酸治疗急性呼吸衰竭的临床疗效()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年02期
页码:
121-123
栏目:
论著
出版日期:
2022-01-15

文章信息/Info

Title:
Clinical Efficacy of Non-invasive Ventilator Combined with N-acetyl L-cysteinein Treatment of Acute Respiratory Failure
文章编号:
1006-1959（2022）02-0121-03
作者:
陈孝辉
天津市宝坻区中医医院呼吸科，天津 301800
Author(s):
CHEN Xiao-hui
Department of Respiratory,Baodi District Hospital of Traditional Chinese Medicine,Tianjin 301800,China
关键词:
急性呼吸衰竭; 无创呼吸机; N-乙酰半胱氨酸; 血气指标
Keywords:
Acute respiratory failure; Non-invasive ventilator; N-acetylcysteine; Blood gas index
分类号:
R563.8
DOI:
10.3969/j.issn.1006-1959.2022.02.029
文献标志码:
A
摘要:
目的 观察无创呼吸机联合N-乙酰半胱氨酸治疗急性呼吸衰竭的临床疗效。方法 选取2018年9月-2021年7月我院接诊的80例急性呼吸衰竭患者为研究对象，按照随机数字表法分为对照组和观察组，各40例。对照组给予无创呼吸机治疗，观察组在对照组基础上给予N-乙酰半胱氨酸治疗，比较两组临床疗效、血气指标（PaO2、SaO2、PaCO2）、临床指标（无创呼吸机治疗时间、住院时间）、肺功能指标（FEV1、FEV1%）以及临床不良反应发生情况。结果 观察组治疗总有效率为95.00%，高于对照组的72.50%（P＜0.05）；观察组PaO2、SaO2均高于对照组，PaCO2低于对照组（P＜0.05）；观察组无创呼吸机治疗时间、住院时间均短于对照组（P＜0.05）；观察组FEV1、FEV1%高于对照组（P＜0.05）；两组不良反应发生率比较，差异无统计学意义（P＞0.05）。结论 无创呼吸机联合N-乙酰半胱氨酸治疗急性呼吸衰竭效果确切，可提高治疗总有效率，改善肺功能和血气指标，促进病情控制，缩短无创呼吸机治疗时间和住院时间，且不会增加临床不良反应。
Abstract:
Objective To observe the clinical efficacy of non-invasive ventilator combined with N-acetylcysteine in the treatment of acute respiratory failure.Methods A total of 80 patients with acute respiratory failure admitted to our hospital from September 2018 to July 2021 were selected as the research objects, and they were randomly divided into the control group and the observation group, with 40 cases in each. The control group was treated with non-invasive ventilator, and the observation group was treated with N-acetylcysteine on the basis of the control group. The clinical efficacy, blood gas indexes (PaO2, SaO2, PaCO2), clinical indexes (noninvasive ventilator treatment time, hospitalization time), pulmonary function indexes (FEV1,FEV1%) and clinical adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.00%, which was higher than 72.50% in the control group (P<0.05). PaO2 and SaO2 in the observation group were higher than those in the control group, while PaCO2 was lower than that in the control group (P<0.05). The time of mechanical treatment and hospital stay were shorter than those of the control group (P<0.05). The FEV1 and FEV1% in the observation group were higher than the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05).Conclusion The effect of noninvasive ventilator combined with N-acetylcysteine in the treatment of acute respiratory failure is exact, which can improve the total effective rate of treatment, improve lung function and blood gas indexes, promote disease control, shorten the treatment time and hospitalization time of noninvasive ventilator, and do not increase clinical adverse reactions.

参考文献/References:

[1]杨宝春,王丽东,孙欣.乙酰半胱氨酸胶囊联合双水平无创正压通气治疗AECOPD合并Ⅱ型呼吸衰竭观察[J].中国药师,2020,23(3):485-487.[2]郝文东,王国芳,张彩莲,等.N-乙酰半胱氨酸联合双水平气道正压通气治疗AE-COPD合并Ⅱ型呼吸衰竭的疗效及作用机制研究[J].现代中西医结合杂志,2018,27(7):724-727.[3]邹玲玲.N-乙酰半胱氨酸与氨溴索联合用药治疗老年慢性阻塞性肺疾病急性加重期的临床疗效及其对患者氧化应激的影响[J].吉林医学,2019,40(12):2810-2811.[4]王静,苗姝.N-乙酰半胱氨酸治疗慢性阻塞性肺疾病急性加重期的效果及对患者氧化应激的影响[J].海南医学,2018,29(8):1051-1054.[5]聂言臣,张特,王宗立.无创呼吸机联合沙美特罗替卡松粉剂吸入治疗慢性阻塞性肺疾病急性加重并发呼吸衰竭的疗效及对患者预后生存质量的影响[J].中国药物与临床,2019,19(8):1229-1231.[6]许红飞,刘艳春,王春鲜.雾化吸入N-乙酰半胱氨酸和复方异丙托溴铵治疗AECOPD的疗效及对血清LTB4,IL-6,PCT和SOD水平的影响[J].国际呼吸杂志,2021,41(16):1246-1252.[7]朱庆利.纳洛酮对慢阻肺并Ⅱ型呼吸衰竭患者PaCO2、pH、PaO2的影响[J].黑龙江医药科学,2018,41(6):97-98.[8]王春畅,靳杨,李颖,等.N-乙酰半胱氨酸辅助治疗对慢性阻塞性肺疾病急性加重期血清降钙素原及前白蛋白的影响[J].广西医学,2018,40(7):792-794.[9]李林静,李华旭,闫东星,等.N-乙酰半胱氨酸联合有氧运动对慢性阻塞性肺疾病稳定期患者肺功能、生活质量及血清氧化因子的影响[J].新乡医学院学报,2018,35(5):407-410.[10]江美芳,刘蔺,秦克.噻托溴铵联合无创呼吸机治疗COPD合并Ⅱ型呼吸衰竭疗效及对患者血气指标和炎症因子的影响[J].标记免疫分析与临床,2020,27(1):132-135,141.[11]许清琴.甲泼尼龙联合无创正压通气对急性呼吸衰竭的临床疗效[J].河南医学研究,2019,28(17):3172-3173. [12]刘祖洪,谭运宝,郭海健,等.无创呼吸机通气联合乙酰半胱氨酸吸入治疗慢性阻塞性肺疾病伴Ⅱ型呼吸衰竭的效果[J].实用临床医学,2020,21(5):19-22,34.[13]李英明,郑冉冉,谢丰建.无创呼吸机联合N-乙酰半胱氨酸治疗急性呼吸衰竭患者的疗效观察[J].国际检验医学杂志,2021,42(13):1639-1641.[14]马群.双水平正压通气联合雾化吸入在慢性阻塞性肺疾病急性加重期合并Ⅱ型呼吸衰竭中的应用[J].山西医药杂志,2018,47(10):73-75.[15]初巍巍,霍阳,王莉,等.N-乙酰半胱氨酸对慢性阻塞性肺疾病急性加重期患者血清中氧化相关物质的影响[J].解放军医药杂志,2014,26(1):40-42.[16]秦篙.联合N-乙酰半胱氨酸对AECOPD患者的治疗效果[J].热带医学杂志,2016,16(4):483-485.[17]何莺.老年急性呼吸衰竭患者治疗中无创呼吸机辅助治疗价值分析[J].临床军医杂志,2017,45(3):262-264.[18]晋荣新,鄢毅.N-乙酰半胱氨酸与盐酸氨溴索治疗小儿支气管肺炎的疗效对比及其对免疫功能和临床症状的影响[J].中国妇幼保健,2018,33(1):118-120.[19]于娜娜,黄磊,朱学专.老年急性呼吸衰竭患者无创呼吸机辅助治疗的价值[J].实用临床医药杂志,2019,23(4):34-36.[20]马春兰,王春茂,李万成,等.噻托溴铵联合N-乙酰半胱氨酸治疗慢性阻塞性肺疾病稳定期的疗效观察[J].海南医学,2018,29(8):1072-1075.

相似文献/References:

[1]李暾,徐伟,李强.ICU 病房应用无创呼吸机治疗老年COPD 并域型呼吸衰竭的临床疗效研究[J].医学信息,2018,31(01):106.[doi:10.3969/j.issn.1006-1959.2018.01.039]
　LI Tun,XU Wei,LI Qiang.Clinical Study of Noninvasive Ventilator in Elderly Patients with COPD and Type 域 Respiratory Failure in ICU Ward[J].Medical Information,2018,31(02):106.[doi:10.3969/j.issn.1006-1959.2018.01.039]
[2]黄朝宗.无创呼吸机对慢性阻塞性肺疾病急性加重患者治疗效果的影响[J].医学信息,2018,31(01):112.[doi:10.3969/j.issn.1006-1959.2018.01.042]
　HUANG Chao-zong.Effect of Noninvasive Ventilator on the Treatment of Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease[J].Medical Information,2018,31(02):112.[doi:10.3969/j.issn.1006-1959.2018.01.042]
[3]朱慧琳,胡丹平,颜金农,等.无创通气对慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭患者BODE的影响[J].医学信息,2021,34(04):130.[doi:10.3969/j.issn.1006-1959.2021.04.034]
　ZHU Hui-lin,HU Dan-ping,YAN Jin-nong,et al.Effect of Non-invasive Ventilation on BODE in Patients with Chronic Obstructive Pulmonary Disease and Type Ⅱ Respiratory Failure[J].Medical Information,2021,34(02):130.[doi:10.3969/j.issn.1006-1959.2021.04.034]
[4]江乐川.新生儿无创呼吸机防治新生儿呼吸窘迫综合征的效果[J].医学信息,2019,32(22):107.[doi:10.3969/j.issn.1006-1959.2019.22.034]
　JIANG Le-chuan.Effect of Neonatal Non-invasive Ventilator on Prevention and Treatment of Neonatal Respiratory Distress Syndrome[J].Medical Information,2019,32(02):107.[doi:10.3969/j.issn.1006-1959.2019.22.034]
[5]王亚敏.无创呼吸机和行气利水方治疗成人轻度阻塞性睡眠呼吸暂停的临床研究[J].医学信息,2021,34(16):181.[doi:10.3969/j.issn.1006-1959.2021.16.052]
　WANG Ya-min.Clinical Study on Non-invasive Ventilator and Xingqi Lishui Recipe in Treating Adults with Mild Obstructive Sleep Apnea[J].Medical Information,2021,34(02):181.[doi:10.3969/j.issn.1006-1959.2021.16.052]
[6]胡言飞,张长敏.2015-2019年山东省某三甲医院抢救室六大病种流行病学分析[J].医学信息,2023,36(17):45.[doi:10.3969/j.issn.1006-1959.2023.17.008]
　HU Yan-fei,ZHANG Chang-min.Epidemiological Analysis of Six Kinds of Diseases in the Emergency Department of a Tertiary Hospital in Shandong Province from 2015 to 2019[J].Medical Information,2023,36(02):45.[doi:10.3969/j.issn.1006-1959.2023.17.008]
[7]谢晓靖,那君艳,蒋月红.乌灵胶囊对呼吸内科无创呼吸机使用患者睡眠质量的改善效果[J].医学信息,2024,37(14):122.[doi:10.3969/j.issn.1006-1959.2024.14.024]
　XIE Xiao-jing,NA Jun-yan,JIANG Yue-hong.Improvement Effect of Wuling Capsule on Sleep Quality of Patients with Non-invasive Ventilator in Respiratory Medicine Department[J].Medical Information,2024,37(02):122.[doi:10.3969/j.issn.1006-1959.2024.14.024]
[8]张欣银.无创呼吸机联合安全护理对慢阻肺合并Ⅱ型呼吸衰竭患者的影响[J].医学信息,2024,37(17):173.[doi:10.3969/j.issn.1006-1959.2024.17.039]
　ZHANG Xin-yin.Effect of Non-invasive Ventilator Combined with Safety Nursing on Patients with Chronic Obstructive Pulmonary Disease Complicated with Type Ⅱ Respiratory Failure[J].Medical Information,2024,37(02):173.[doi:10.3969/j.issn.1006-1959.2024.17.039]
[9]国 旭.集束化护理对无创呼吸机治疗心衰患者的护理效果及对左心功能的影响[J].医学信息,2024,37(20):167.[doi:10.3969/j.issn.1006-1959.2024.20.036]
　GUO Xu.Nursing Effect of Cluster Nursing on Patients with Heart Failure Treated by Continuous Positive Airway Pressure and its Influence on Left Ventricular Function[J].Medical Information,2024,37(02):167.[doi:10.3969/j.issn.1006-1959.2024.20.036]

更新日期/Last Update: 1900-01-01