[1]李 莲.丁苯酞注射液联合阿托伐他汀钙对急性脑梗死患者脑血流变及神经功能的影响[J].医学信息,2022,35(20):63-66.[doi:10.3969/j.issn.1006-1959.2022.20.015]
　LI Lian.Effect of Butylphthalide Injection Combined with Atorvastatin Calcium on Cerebral Hemorheology and Neurological Function in Patients with Acute Cerebral Infarction[J].Journal of Medical Information,2022,35(20):63-66.[doi:10.3969/j.issn.1006-1959.2022.20.015]
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丁苯酞注射液联合阿托伐他汀钙对急性脑梗死患者脑血流变及神经功能的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年20期
页码:
63-66
栏目:
论著
出版日期:
2022-10-15

文章信息/Info

Title:
Effect of Butylphthalide Injection Combined with Atorvastatin Calcium on Cerebral Hemorheology and Neurological Function in Patients with Acute Cerebral Infarction
文章编号:
1006-1959（2022）20-0063-04
作者:
李 莲
（奉新县人民医院神经内科，江西 奉新 330700）
Author(s):
LI Lian
(Department of Neurology,Fengxin County People’s Hospital,Fengxin 330700,Jiangxi,China)
关键词:
急性脑梗死; 丁苯酞注射液; 阿托伐他汀钙; 脑血流变; 神经功能
Keywords:
Acute cerebral infarction; Butylphthalide injection; Atorvastatin calcium; Cerebral blood rheology; Nerve function
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2022.20.015
文献标志码:
A
摘要:
目的 观察急性脑梗死患者联合应用丁苯酞注射液与阿托伐他汀钙治疗对脑血流变及神经功能的影响。方法 选择2020年1月-12月奉新县人民医院神经内科收治的急性脑梗死患者60例，根据随机数字表法分为治疗组和对照组，各30例。对照组给予阿托伐他汀钙治疗，治疗组在对照组基础上联合丁苯酞注射液治疗。比较两组收缩期峰值流速（PSV）、搏动指数（PI）、舒张期末血流速度（EDV）、格拉斯哥昏迷指数（GCS评分）、同型半胱氨酸（HCY）、颅外椎动脉（VA）、颈内动脉（ICA）的血液平均流速（Vm）、血流变异减速（Vd）、血流最低流速（Vs）。结果 治疗7 d后，治疗组PSV、EDV高于对照组（P＜0.05），而两组VA、ICA的PI比较，差异无统计学意义（P＞0.05）；治疗组GCS评分高于对照组，HCY水平低于对照组（P＜0.05）；治疗组VA、ICA的Vs、Vd、Vm高于对照组（P＜0.05）。结论 急性脑梗死患者联合应用丁苯酞注射液与阿托伐他汀钙治疗可降低颅内压，减轻神经功能及氧自由基损伤，改善脑血流变，提高脑功能，临床应用效果良好。
Abstract:
Objective To observe the effect of butylphthalide injection combined with atorvastatin calcium on cerebral hemorheology and neurological function in patients with acute cerebral infarction.Methods Sixty patients with acute cerebral infarction admitted to the Department of Neurology, Fengxin County People’s Hospital from January to December 2020 were selected and divided into a treatment group and a control group according to the random number table method, with 30 cases in each group. The control group was treated with atorvastatin calcium, and the treatment group was treated with butylphthalide injection on the basis of the control group. The peak systolic velocity (PSV), pulsatility index (PI), end diastolic velocity (EDV), Glasgow coma score (GCS), homocysteine (HCY), mean blood flow velocity (Vm), deceleration of blood flow variability (Vd) and minimum blood flow velocity (Vs) of extracranial vertebral artery (VA) and internal carotid artery (ICA) were compared between the two groups.Results After 7 days of treatment, PSV and EDV in the treatment group were higher than those in the control group (P<0.05), but there was no significant difference in PI of VA and ICA between the two groups (P>0.05). The GCS score of the treatment group was higher than that of the control group, and the HCY level was lower than that of the control group (P<0.05). The Vs, Vd and Vm of VA and ICA in the treatment group were higher than those in the control group (P<0.05).Conclusion The combination of butylphthalide injection and atorvastatin calcium in patients with acute cerebral infarction can reduce intracranial pressure, reduce neurological function and oxygen free radical damage, improve cerebral blood flow and improve brain function, and the clinical application effect is good.

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