[1]张舒颖,夏海龙.血脂和载脂蛋白水平与多发性骨髓瘤贫血的相关性[J].医学信息,2023,36(04):136-139.[doi:10.3969/j.issn.1006-1959.2023.04.027]
　ZHANG Shu-ying,XIA Hai-long.Correlation Between Blood Lipid, Apolipoprotein Levels and Anemia of Multiple Myeloma[J].Journal of Medical Information,2023,36(04):136-139.[doi:10.3969/j.issn.1006-1959.2023.04.027]
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血脂和载脂蛋白水平与多发性骨髓瘤贫血的相关性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年04期
页码:
136-139
栏目:
论著
出版日期:
2023-02-15

文章信息/Info

Title:
Correlation Between Blood Lipid, Apolipoprotein Levels and Anemia of Multiple Myeloma
文章编号:
1006-1959（2023）04-0136-04
作者:
张舒颖; 夏海龙
（1.安徽医科大学附属巢湖医院血液内科，安徽 巢湖 238000；2.安徽医科大学第一附属医院血液内科，安徽 合肥 230022）
Author(s):
ZHANG Shu-ying; XIA Hai-long
(1.Department of Hematology,Chaohu Affiliated Hospital of Anhui Medical University,Chaohu 238000,Anhui,China;2.Department of Hematology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui,China)
关键词:
多发性骨髓瘤; 载脂蛋白; 贫血程度; 血脂水平
Keywords:
Multiple myeloma; Apolipoprotein; Degree of anemia; Blood lipid levels
分类号:
R733.3
DOI:
10.3969/j.issn.1006-1959.2023.04.027
文献标志码:
A
摘要:
目的 探讨多发性骨髓瘤（MM）患者贫血与血脂和载脂蛋白的关系。方法 选取2019年1月-2021年12月安徽医科大学第一附属医院和安徽医科大学附属巢湖医院138例初诊MM患者作为MM组，选取正常体检者80名作为对照组，比较MM组和对照组及不同分期、贫血程度MM患者TC、TG、HDL-C、LDL-C、APOA、APOB水平，并分析TC、TG、HDL-C、LDL-C、APOA、APOB与贫血的相关性。结果 MM组TC、HDL-C、LDL-C、APOA、APOB水平均低于对照组，差异有统计学意义（P＜0.05），而两组TG水平比较，差异无统计学意义（P＞0.05）；不同分期、贫血程度MM患者TC、HDL-C、LDL-C、APOA、APOB水平比较，差异有统计学意义（P＜0.05），而不同分期、贫血程度MM患者TG水平比较，差异无统计学意义（P＞0.05）； MM患者贫血与TC、HDL-C、LDL-C、APOA、APOB水平呈正相关（P＜0.05），与TG水平无相关性（P＞0.05）。结论 血脂水平紊乱与MM临床分期及贫血程度密切相关。
Abstract:
Objective To investigate the relationship between anemia and serum lipids and apolipoproteins in patients with multiple myeloma (MM).Methods A total of 138 newly diagnosed MM patients in the First Affiliated Hospital of Anhui Medical University and Chaohu Hospital of Anhui Medical University from January 2019 to December 2021 were selected as the MM group, and 80 normal subjects were selected as the control group. The levels of TC, TG, HDL-C, LDL-C, APOA and APOB in MM group, control group and MM patients with different stages and anemia were compared, and the correlation between TC, TG, HDL-C, LDL-C, APOA, APOB and anemia was analyzed.Results The levels of TC, HDL-C, LDL-C, APOA and APOB in MM group were lower than those in control group (P<0.05), while there was no significant difference in TG level between the two groups (P>0.05). The levels of TC, HDL-C, LDL-C, APOA and APOB in MM patients with different stages and degrees of anemia were significantly different (P<0.05), while there was no significant difference in TG level between MM patients with different stages and degrees of anemia (P>0.05). The anemia of MM patients was positively correlated with the levels of TC, HDL-C, LDL-C, APOA and APOB (P<0.05), there was no correlation between anemia and TG level (P>0.05).Conclusion The levels of TC, HDL-C, LDL-C, APOA and APOB in multiple myeloma patients decreased, which were negatively correlated with the clinical stage of ISS, and the above indexes decreased more significantly with the severity of anemia.

参考文献/References:

[1]Sung H,Ferlay J,Siegel RL,et al.Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries[J].CA Cancer J Clin,2021,71(3):209-249.[2]Kyle RA,Gertz MA,Witzig TE,et al.Review of 1027 patients with newly diagnosed multiple myeloma[J].Mayo Clin Proc,2003,78(1):21-33.[3]Teixeira RS,Arriaga MB,Terse-Ramos R,et al.Higher values of triglycerides:HDL-cholesterol ratio hallmark disease severity in children and adolescents with sickle cell anemia[J]. Braz J Med Biol Res,2019,52(10):e8833.[4]Ozdemir A,Sevinc C,Selamet U,et al.The relationship between iron deficiency anemia and lipid metabolism in premenopausal women[J].Am J Med Sci,2007,334(5):331-333.[5]刘延鑫,高弼虎,王路平,等.慢性肾衰竭患者的肾性贫血同血脂和钙磷代谢之间的相关性研究[J].中国医学装备,2021,18(3):109-112.[6]中国医师协会血液科医师分会,中华医学会血液学分会,中国医师协会多发性骨髓瘤专业委员会.中国多发性骨髓瘤诊治指南(2020年修订)[J].中华内科杂志,2020,59(5):341-346.[7]中国临床肿瘤学会肿瘤相关性贫血专家委员会.肿瘤相关性贫血临床实践指南(2015-2016版)[J].中国实用内科杂志,2015,35(11):921-930.[8]孙伟峰,张健,朱旭明,等.多发性骨髓瘤初发患者贫血相关的检验观察[J].南京医科大学学报(自然科学版),2013,33(1):110-112.[9]Banaszkiewicz M,Malyszko J,Vesole DH,et al.New Biomarkers of Ferric Management in Multiple Myeloma and Kidney Disease-Associated Anemia[J].J Clin Med,2019,8(11):1828.[10]刘琳,聂鼎睿,安超,等.多发性骨髓瘤患者血清EPO、IL-6、TNF-α、IL-1β水平及其与贫血的相关性分析[J].河南医学研究,2021,30(8):1369-1373.[11]Birgeg?覽rd G,Gascón P,Ludwig H.Evaluation of anaemia in patients with multiple myeloma and lymphoma: findings of the European CANCER ANAEMIA SURVEY[J].European Journal of Haematology,2006,77(5):378-386.[12]傅爱林,沈刚,沈文香,等.贫血程度对多发性骨髓瘤患者免疫功能和生活质量的影响[J].山东医药,2016,56(32):76-78.[13]Shirvani M,Vakili SM,Hosseini SR,et al.Does Serum lipid profile differ in anemia and non-anemic older subjects?[J].Caspian J Intern Med,2017,8(4):305-310.[14]Li J,Yang M,Yu Z,et al.Kidney-secreted erythropoietin lowers lipidemia via activating JAK2-STAT5 signaling in adipose tissue[J].EBioMedicine,2019,50:317-328.[15]罗娜,时荣臣,代荣阳,等.胆固醇代谢与肿瘤免疫[J].四川大学学报(医学版),2022,53(2):335-341.[16]陈杰翔,安宏元,李利.前列腺癌患者血脂水平及临床意义[J].中国老年学杂志,2021,41(18):3950-3952.[17]Jeong S,Choi T,Kim D,et al.Association between high-density lipoprotein cholesterol level and risk of hematologic malignancy[J].Leukemia,2021,35(5):1356-1364.[18]吴良华,丁芳,吴振添,等.多发性骨髓瘤患者化疗前后血脂变化的临床研究[J].中外医学研究,2018,16(23):154-156.[19]杨文丽,李晓明.多发性骨髓瘤患者血脂的检测及临床意义[J].现代肿瘤医学,2021,29(19):3458-3461.[20]赵冰,张文静,尹秀秀,等.青年贫血和血脂相关性研究[J].中国卫生检验杂志,2016,26(13):1829-1832.[21]Purnamasari SD,Hsu C,Chen Y,et al.Combined Low Plant and High Animal Dietary Pattern Is Associated with a Lower Risk of Anemia among Dyslipidemic Adult Women in Taiwan: A Retrospective Study from 2001 to 2015[J].International Journal of Environmental Research and Public Health,2022,19(10):6231.

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更新日期/Last Update: 1900-01-01