[1]郭晓明,王丽萍,杨 菲,等.不同年龄对胆总管结石内镜治疗中复合羟考酮麻醉时丙泊酚靶控输注EC50的影响[J].医学信息,2023,36(08):90-93.[doi:10.3969/j.issn.1006-1959.2023.08.018]
　GUO Xiao-ming,WANG Li-ping,YANG Fei,et al.Effects of Different Ages on EC50 of Propofol Target-controlled Infusion During Compound Oxycodone Anesthesia in Endoscopic Treatment of Common Bile Duct Stones[J].Journal of Medical Information,2023,36(08):90-93.[doi:10.3969/j.issn.1006-1959.2023.08.018]
点击复制

不同年龄对胆总管结石内镜治疗中复合羟考酮麻醉时丙泊酚靶控输注EC50的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年08期
页码:
90-93
栏目:
论著
出版日期:
2023-04-15

文章信息/Info

Title:
Effects of Different Ages on EC50 of Propofol Target-controlled Infusion During Compound Oxycodone Anesthesia in Endoscopic Treatment of Common Bile Duct Stones
文章编号:
1006-1959（2023）08-0090-04
作者:
郭晓明; 王丽萍; 杨 菲; 等
（福建医科大学福总临床医学院/联勤保障部队第九〇〇医院麻醉科，福建 福州 350000）
Author(s):
GUO Xiao-ming; WANG Li-ping; YANG Fei; et al.
(Department of Anesthesiology,Fuzhou General Clinical Medical College of Fujian Medical University/the 900th Hospital of Joint Logistics Support Force,Fuzhou 350000,Fujian,China)
关键词:
内镜逆行胰胆管造影; 羟考酮; 丙泊酚; 靶控输注; 半数有效浓度
Keywords:
Endoscopic retrograde cholangiopancreatography; Oxycodone; Propofol; Target-controlled infusion; 50% effective concentration
分类号:
R971+.2
DOI:
10.3969/j.issn.1006-1959.2023.08.018
文献标志码:
A
摘要:
目的 研究不同年龄对胆总管结石内镜治疗患者复合羟考酮麻醉时丙泊酚靶控输注EC50的影响。方法 选择2017年5月-2018年8月于联勤保障部队第九〇〇医院消化内科诊断为胆总管结石并择期行ERCP合并EST的患者120例作为研究对象，根据年龄段不同分为4组，分别为青年组（A组）、中年组（B组）、低剂量老年组（C组）、中剂量老年组（D组），每组30例。麻醉开始前5 min，A、B、D组患者均静脉注射0.1 mg/kg羟考酮，C组患者静脉注射0.08 mg/kg羟考酮。所有患者均实施丙泊酚靶控输注麻醉，待意识消失后，丙泊酚效应室浓度以0.2 μg／ml的梯度滴定致入镜反应为阴性，并记录此时丙泊酚效应室浓度，另比较各组低血压、低心率、低氧血症发生率。结果 A、B、C、D组致入镜反应阴性的丙泊酚EC50分别为：3.50（3.42~3.57）μg/ml、3.41（3.33~3.45）μg/ml、3.12（3.04~3.19）μg/ml、3.09（3.01~3.16）μg/ml。与A、B组比较，C、D组致入镜反应阴性丙泊酚EC50均下降（P＜0.05）；A、B组致入镜反应阴性丙泊酚EC50比较，差异无统计学意义（P＞0.05）；C、D组致入镜反应阴性丙泊酚EC50比较，差异无统计学意义（P＞0.05）。四组低血压、心动过缓、低氧血症发生率比较，差异均无统计学意义（P＞0.05）。结论 胆总管结石患者内镜治疗复合羟考酮麻醉时，青年人和中年人丙泊酚EC50无明显差异，老年人羟考酮推荐剂量为0.08 mg/kg，其丙泊酚EC50为3.12 μg/ml。
Abstract:
Objective To investigate the effect of different ages on the EC50 of propofol target-controlled infusion during compound oxycodone anaesthesia in patients undergoing endoscopic surgery for common bile duct stones.Methods A total of 120 patients with common bile duct stones diagnosed in the Department of Gastroenterology, the 900th Hospital of the Joint Logistics Support Force from May 2017 to August 2018 and scheduled for ERCP combined with EST were selected as the research objects. According to different age groups, they were divided into four groups: young group (group A), middle-aged group (group B), low-dose elderly group (group C) and middle-dose elderly group (group D), with 30 cases in each group. Five minutes before the initiation of anesthesia, patients in groups A, B, and D received 0.1 mg/kg oxycodone intravenously, and patients in group C received 0.08 mg/kg oxycodone intravenously. Propofol target controlled infusion anesthesia was implemented in all patients. After the patient became unconscious, the propofol effect chamber concentration was adjusted to 0.2 μg/ml of the gradient titrated to an entry lens reaction that was negative and the propofol effect chamber concentration was recorded at this time. Hypotension, low heart rate, hypoxemia and other adverse events among four groups were compared.Results The EC50 of propofol in groups A ,B, C, and D who had a negative admission lens reaction were: 3.50(3.42-3.57)μg/ml, 3.41(3.33-3.45)μg/ml, 3.12(3.04-3.19)μg/ml, 3.09(3.01-3.16)μg/ml。Compared with groups A and B, the EC50 of propofol in groups C and D who had a negative admission lens reaction all decreased (P<0.05). The EC50 of propofol in groups A and B who resulted in a negative admission lens was not statistically different (P>0.05). The EC50 of propofol in groups C and D who resulted in a negative admission lens response was also not statistically different (P>0.05). There was no significant difference in the incidence of hypotension, bradycardia and hypoxemia among the four groups (P>0.05).Conclusion There was no significant difference in the EC50 of propofol between young and middle-aged patients who underwent endoscopic surgery under combined oxycodone anesthesia for common bile duct stones, and the recommended dose of oxycodone for the elderly was 0.08 mg/kg, whose EC50 of propofol was 3.12 μg/ml.

参考文献/References:

[1]Liu J,Liu X,Peng LP,et al.Efficacy and safety of intravenous lidocaine in propofol-based sedation for ERCP procedures:a prospective,randomized,double-blinded,controlled trial[J].Gastrointest Endosc,2020,92(2):293-300.[2]Ogawa T,Tomoda T,Kato H,et al.Propofol sedation with a target-controlled infusion pump in elderly patients undergoing ERCP[J].Gastrointest Endosc,2020,92(2):301-307.[3]Lazzari M,Sabato AF,Caldarulo C,et al.Effectiveness and tolerability of low-dose oral oxycodone/naloxone added to anticonvulsant therapy for noncancer neuropathic pain: an observational analysis[J].Curr Med Res Opin,2014,30(4):555-564.[4]Mc Nicol ED,Midbari A,Eisenberg E.Opioids for neuropathic pain[J].Cochrane Database Syst Rev,2013,2013(8):CD006146.[5]Staahl C,Christrup LL,Andersen SD,et al.A comparative study of oxycodone and morphine in a multi-modal,tissue-differentiated experimental pain model[J].Pain,2006,123(1-2):28-36.[6]徐建国.盐酸羟考酮的药理学和临床应用[J].临床麻醉学杂志,2014,30(5):511-513.[7]郭晓明,吴黄辉,王丽萍,等.不同剂量羟考酮复合丙泊酚靶控输注麻醉在胆总管结石患者内镜治疗中的比较[J].实用医学杂志,2018,34(2):277-280,284.[8]吴群林,张兴安,王若松,等.年龄对异丙酚药效学的影响[J].中华麻醉学杂志,2001,21(3):146-148.[9]Li S,Sheng G,Teng Y,et al.Systematic review of anaesthetic medication for ERCP based on a network meta-analysis[J].Int J Surg,2018,51:56-62.[10]Eberl S,Koers L,van Hooft JE,et al.Sedation with propofol during ERCP: is the combination with esketamine more effective and safer than with alfentanil? Study protocol for a randomized controlled trial[J].Trials,2017,18(1):472.[11]Haytural C,Ayd?覦nl?覦 B,Demir B,et al.Comparison of Propofol,Propofol-Remifentanil,and Propofol-Fentanyl Administrations with Each Other Used for the Sedation of Patients to Undergo ERCP[J].Biomed Res Int,2015,2015:465465.[12]Hemlata DR,Verma DR,Siddqui DA,et al.Effects of fentanyl and lignocaine on propofol injection pain: a randomized,placebo[J].International Journal of Current Advanced Research,2021,10(2{A}):23753-23758.[13]Poyhia R,Seppala T,Olkkola KT,et al.The pharmacokinetics and metabolism of oxycodone after intramuscular and oral administration to healthy subjects[J].British Journal of Clinical Pharmacology,2012,33(6):617-621.[14]Finkel JC,Pukish J.Molecular Biology of Opioid Analgesia and Its Clinical Considerations[J].Clin J Pain,2019,35(6):473-480.[15]张英,陈巍巍,章炳法,等.丙泊酚静脉麻醉辅助单人结肠镜检查的临床价值[J].浙江临床医学,2017,19(9):1724-1725.[16]Eberl S,Koers L,van Hooft J,et al.The effectiveness of a low-dose esketamine versus an alfentanil adjunct to propofol sedation during endoscopic retrograde cholangiopancreatography: A randomised controlled multicentre trial[J].Eur J Anaesthesiol,2020,37(5):394-401.[17]Burton FM,Lowe DJ,Millar J,et al.Propofol Target-Controlled Infusion in Emergency Department Sedation (ProTEDS): a multicentre,single-arm feasibility study[J].Emerg Med J,2021,38(3):205-210.[18]Dennhardt N,Boethig D,Beck C,et al.Optimization of initial propofol bolus dose for EEG Narcotrend Index-guided transition from sevoflurane induction to intravenous anesthesia in children[J].Paediatr Anaesth,2017,27(4):425-432.[19]Meng D,Zhang X,Yu P,et al.Analysis of influence factors of pharmacodynamics of propofol with target-controlled infusion during anesthetic recovery period[J].Int J Clin Pharmacol Ther,2021,59(2):109-115.

相似文献/References:

[1]刘卫东,王士雷.罗哌卡因复合羟考酮收肌管阻滞在膝关节镜手术ERAS中的应用[J].医学信息,2018,31(19):111.[doi:10.3969/j.issn.1006-1959.2018.19.033]
　LIU Wei-dong,WANG Shi-lei.Application of Ropivacaine Combined with Hydroxycodone Adductor Tube Block in ERAS of Knee Arthroscopy[J].Journal of Medical Information,2018,31(08):111.[doi:10.3969/j.issn.1006-1959.2018.19.033]
[2]唐 勇,周 乐.羟考酮用于宫外孕手术患者全麻诱导插管的临床研究[J].医学信息,2019,32(15):136.[doi:10.3969/j.issn.1006-1959.2019.15.044]
　TANG Yong,ZHOU Le.Clinical Study of Oxycodone in General Anesthesia Induced Intubation in Patients Undergoing Ectopic Pregnancy[J].Journal of Medical Information,2019,32(08):136.[doi:10.3969/j.issn.1006-1959.2019.15.044]
[3]陈 帆,胡继成,柴小青,等.羟考酮联合舒芬太尼术后镇痛对胃癌根治术患者细胞免疫功能的影响[J].医学信息,2021,34(13):160.[doi:10.3969/j.issn.1006-1959.2021.13.044]
　CHEN Fan,HU Ji-cheng,CHAI Xiao-qing,et al.Effects of Postoperative Analgesia of Oxycodone Combined with Sufentanyl on Cellular Immune Function in Patients Undergoing Radical Gastric Cancer Surgery[J].Journal of Medical Information,2021,34(08):160.[doi:10.3969/j.issn.1006-1959.2021.13.044]
[4]张明月,夏晓琼,余泳波,等.不同阿片类药物对老年患者无痛肠镜检查延迟性恶心呕吐的影响[J].医学信息,2024,37(10):121.[doi:10.3969/j.issn.1006-1959.2024.10.025]
　ZHANG Ming-yue,XIA Xiao-qiong,YU Yong-bo,et al.Effects of Different Opioids on Delayed Nausea and Vomiting in Elderly Patients Undergoing Painless Enteroscopy[J].Journal of Medical Information,2024,37(08):121.[doi:10.3969/j.issn.1006-1959.2024.10.025]

更新日期/Last Update: 1900-01-01