[1]陈华春,吴晓虞,陈桂园,等.免疫检查点抑制剂相关神经毒性的诊治现状及研究进展[J].医学信息,2023,36(08):175-179.[doi:10.3969/j.issn.1006-1959.2023.08.039]
 CHEN Hua-chun,WU Xiao-yu,CHEN Gui-yuan,et al.Current Status and Research Progress in the Diagnosis and Management of Immune Checkpoint Inhibitor-related Neurotoxicity[J].Journal of Medical Information,2023,36(08):175-179.[doi:10.3969/j.issn.1006-1959.2023.08.039]
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免疫检查点抑制剂相关神经毒性的诊治现状及研究进展()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年08期
页码:
175-179
栏目:
综述
出版日期:
2023-04-15

文章信息/Info

Title:
Current Status and Research Progress in the Diagnosis and Management of Immune Checkpoint Inhibitor-related Neurotoxicity
文章编号:
1006-1959(2023)08-0175-05
作者:
陈华春吴晓虞陈桂园
(1.金华广福肿瘤医院呼吸与危重症医学科,浙江 金华 321000;2.金华职业技术学院医学院,浙江 金华 321007)
Author(s):
CHEN Hua-chunWU Xiao-yuCHEN Gui-yuanet al.
(1.Department of Respiratory and Critical Care Medicine,Jinhua Guangfu Cancer Hospital,Jinhua 321000,Zhejiang,China; 2.School of Medicine,Jinhua Polytechnic,Jinhua 321007,Zhejiang,China)
关键词:
免疫检查点抑制剂免疫相关不良事件神经毒性糖皮质激素
Keywords:
Immune checkpoint inhibitorsImmune-related adverse eventsNeurotoxicityGlucocorticoid
分类号:
R730.5
DOI:
10.3969/j.issn.1006-1959.2023.08.039
文献标志码:
A
摘要:
免疫检查点抑制剂(ICIs)在肿瘤治疗方面取得了突破性进展。接受ICIs治疗的患者可能会因免疫系统活动上调而出现免疫相关不良事件(irAEs)。随着ICIs使用增加,irAEs的报道越来越频繁,并成为许多患者的重要挑战。神经系统irAEs包括脑炎、脊髓炎、脑膜炎、周围神经病、重症肌无力和肌炎等,由一组独特的神经炎症疾病组成。这些疾病罕见但严重,死亡率很高。神经系统irAEs患者通常对免疫调节疗法有反应。因此,早期识别和治疗是改善其预后的重要途径。
Abstract:
Immune checkpoint inhibitors (ICIs) have made a breakthrough in cancer therapy. Patients treated with ICIs may develop immune-related adverse events (irAEs) due to the upregulated activity of the immune system. With the increasing use of ICIs, irAEs are more frequently reported and have become important challenges in many patients. Neurological irAEs, which include encephalitis, myelitis, aseptic meningitis, peripheral neuropathy, myasthenia gravis, and myositis, consist of a distinct group of neuroinflammatory disorders. These disorders are rare but frequently severe with high mortality. Patients with neurological irAEs are generally responsive to immune-modulating therapy. Therefore, early recognition and treatment are the most important ways to improve their prognosis.

参考文献/References:

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更新日期/Last Update: 1900-01-01