[1]张冠卿,龙 勇,余海彬,等.治疗前NLR对ICIs治疗非小细胞肺癌患者的预后预测价值的Meta分析[J].医学信息,2024,37(07):30-35.[doi:10.3969/j.issn.1006-1959.2024.07.005]
 ZHANG Guan-qing,LONG Yong,YU Hai-bin,et al.Meta-analysis of the Prognostic Value of Pre-treatment NLR in Patients with Non-small Cell Lung Cancer Treated with ICIs[J].Journal of Medical Information,2024,37(07):30-35.[doi:10.3969/j.issn.1006-1959.2024.07.005]
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治疗前NLR对ICIs治疗非小细胞肺癌患者的预后预测价值的Meta分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年07期
页码:
30-35
栏目:
医学数据科学
出版日期:
2024-04-01

文章信息/Info

Title:
Meta-analysis of the Prognostic Value of Pre-treatment NLR in Patients with Non-small Cell Lung Cancer Treated with ICIs
文章编号:
1006-1959(2024)07-0030-06
作者:
张冠卿龙 勇余海彬
(郑州大学第二附属医院胸外科1,介入科2,河南 郑州 471000)
Author(s):
ZHANG Guan-qingLONG YongYU Hai-binet al.
(Department of Thoracic Surgery1,Department of Interventional2,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 471000,Henan,China)
关键词:
非小细胞肺癌中性粒细胞与淋巴细胞比值免疫检查点抑制剂
Keywords:
Non-small cell lung cancerNeutrophil to lymphocyte ratioImmune checkpoint inhibitors
分类号:
R734.2
DOI:
10.3969/j.issn.1006-1959.2024.07.005
文献标志码:
A
摘要:
目的 通过Meta分析探讨治疗前NLR在接受ICIs治疗的NSCLC患者中的预后预测价值。方法 系统检索中文数据库(中国知网、维普、万方)和英文数据库(EMbase、PubMed、The Cochrane Library)中自建库至2022年6月发表的关于治疗前NLR与接受ICIs治疗的NSCLC患者预后关系的文献,使用NOS评分量表评价文献质量,采用STATA 15.0统计软件进行Meta分析。结果 最终纳入24篇中英文文献,共2471位患者。接受ICIs治疗的患者中高NLR与较短的PFS(HR:1.82,95%CI:1.61~2.05)和较差的OS(HR:2.52,95%CI:2.18~2.90)有关,亚组分析结果与合并结果一致(P<0.001)。结论 治疗前NLR可作为接受ICIs治疗的NSCLC患者的潜在预后生物学标志物。
Abstract:
Objective To explore the prognostic value of pre-treatment NLR in NSCLC patients treated with ICIs by Meta-analysis.Methods A systematic search of Chinese databases (CNKI, VIP, Wanfang) and English databases (EMbase, PubMed, The Cochrane Library) from the establishment of the database to June 2022 was conducted to retrieve the literature on the relationship between pre-treatment NLR and the prognosis of NSCLC patients treated with ICIs. The NOS score scale was used to evaluate the quality of the literature. STATA 15.0 statistical software was used for meta-analysis.Results Finally, 24 Chinese and English literatures were included, with a total of 2471 patients. High NLR was associated with shorter PFS (HR:1.82,95%CI:1.61-2.05) and poorer OS (HR:2.52,95%CI:2.18-2.90) in patients treated with ICIs, the results of subgroup analysis were consistent with the combined results (P<0.001).Conclusion NLR before treatment can be used as a potential prognostic biomarker for NSCLC patients treated with ICIs.

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更新日期/Last Update: 1900-01-01